RESUMO
Improvements in dosimetry in preclinical radiation research facilitate the application of results to the newest radiotherapy techniques, reducing gaps that hinder translation. Currently, guidelines for small-field kV photon dosimetry of small animal irradiators have not been published, and most of the publications are based on radiochromic film dosimetry. In this study, we evaluated the performance of four detectors, three ionization chambers (ICs): (PTW Advanced Markus, PTW Semiflex 31010, PTW PinPoint-3D 31016) and one solid-state detector (PTW 60017 unshielded Diode E) regarding their suitability for relative dosimetry of the small animal radiation research platform SARRP (220 kVp). The measurements were performed in a high-resolution 3D scanning phantom, centering the detectors in the field following the in-plane and cross-plane profiles method at two depths. Depth dose curves (PDDs) and profiles were measured in water for field sizes ranging from 40 × 40 mm2 to 5 × 5 mm2. Quantitative analysis was performed through global and local dose differences (DDs) between the PDDs and the Advanced Markus parallel plate IC data and through the gamma index (γ) criteria for profiles compared against data from EBT3 films provided by the manufacturer. Compared to the Advanced Markus IC, the PDD results suggest that PinPoint-3D is suitable for depth measurements at this beam quality, even near the surface, with agreements better than 1%. Semiflex 31010 was accurate to within 1.5% for measurements deeper than 5 mm. Diode E showed a dramatic DD and should not be recommended for the field sizes and kVp evaluated in this study. In agreement with γ analyses, PinPoint-3D and Diode E are good candidates for profile measurements of field sizes from 40 × 40 mm2 to 10 × 10 mm2. For 5 × 5 mm2 profiles, only Diode E showed good results, making it a recommended detector for profile measurements.
Assuntos
Dosimetria Fotográfica/instrumentação , Dosimetria Fotográfica/métodos , Imagens de Fantasmas , Fótons , Animais , Água/químicaRESUMO
PURPOSE: Dose escalation to rectal tumors leads to higher complete response rates and may thereby enable omission of surgery. Important advantages of endoluminal boosting techniques include the possibility to apply a more selective/localized boost than using external beam radiotherapy. A novel brachytherapy (BT) rectal applicator with lateral shielding was designed to be used with a rectoscope for eye-guided positioning to deliver a dose distribution similar to the one of contact x-ray radiotherapy devices, using commonly available high-dose-rate 192Ir BT sources. METHODS AND MATERIALS: A cylindrical multichannel BT applicator with lateral shielding was designed by Monte Carlo modeling, validated experimentally with film dosimetry and compared with results found in the literature for the Papillon 50 (P50) contact x-ray radiotherapy device regarding rectoscope dimensions, radiation beam shape, dose fall-off, and treatment time. RESULTS: The multichannel applicator designed is able to deliver 30 Gy under 13 min with a 20350 U (5 Ci) source. The use of multiple channels and lateral shielding provide a uniform circular treatment surface with 22 mm in diameter. The resulting dose fall-off is slightly steeper (maximum difference of 5%) than the one generated by the P50 device with the 22 mm applicator. CONCLUSIONS: A novel multichannel rectal applicator for contact radiotherapy with high-dose-rate 192Ir sources that can be integrated with commercially available treatment planning systems was designed to produce a dose distribution similar to the one obtained by the P50 device.
Assuntos
Braquiterapia/instrumentação , Radioisótopos de Irídio/administração & dosagem , Planejamento da Radioterapia Assistida por Computador/instrumentação , Neoplasias Retais/radioterapia , Braquiterapia/métodos , Desenho de Equipamento/métodos , Dosimetria Fotográfica/métodos , Humanos , Método de Monte Carlo , Dosagem Radioterapêutica , Planejamento da Radioterapia Assistida por Computador/métodos , Reto/efeitos da radiaçãoRESUMO
The purpose of this study was to evaluate patient and medical staff absorbed doses received from transarterial chemoembolisation of hepatocellular carcinoma, which is the most common primary liver tumour worldwide. The study was performed in three hospitals in Recife, capital of the state of Pernambuco, located in the Brazilian Northeastern region. Two are public hospitals (A and B), and one is private (C). For each procedure, the number of images, irradiation parameters (kV, mA and fluoroscopy time), the air kerma-area product (PKA) and the cumulative air kerma (Ka,r) at the reference point were registered. The maximum skin dose (MSD) of the patient was estimated using radiochromic film. For the medical staff dosimetry, thermoluminescence dosemeters (TLD-100) were attached next to the eyes, close to the thyroid (above the shielding), on the thorax under the apron, on the wrist and on the feet. The effective dose to the staff was estimated using the algorithm of von Boetticher. The results showed that the mean value of the total PKA was 267.49, 403.83 and 479.74 Gy cm(2) for Hospitals A, B and C, respectively. With regard to the physicians, the average effective dose per procedure was 17 µSv, and the minimum and maximum values recorded were 1 and 41 µSy, respectively. The results showed that the feet received the highest doses followed by the hands and lens of the eye, since the physicians did not use leaded glasses and the equipment had no lead curtain.
Assuntos
Carcinoma Hepatocelular/radioterapia , Quimioembolização Terapêutica/métodos , Neoplasias Hepáticas/radioterapia , Exposição Ocupacional/prevenção & controle , Radiologia Intervencionista/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Ar , Algoritmos , Brasil , Calibragem , Dosimetria Fotográfica/métodos , Fluoroscopia/métodos , Humanos , Pessoa de Meia-Idade , Roupa de Proteção , Doses de Radiação , Exposição à Radiação , Radiometria , Pele/efeitos da radiação , Dosimetria TermoluminescenteRESUMO
This work investigated the suitability of passive dosimeters for reference dosimetry in small fields with acceptable accuracy. Absorbed dose to water rate was determined in nine small radiation fields with diameters between 4 and 35 mm in a Leksell Gamma Knife (LGK) and a modified linear accelerator (linac) for stereotactic radiosurgery treatments. Measurements were made using Gafchromic film (MD-V2-55), alanine and thermoluminescent (TLD-100) dosimeters and compared with conventional dosimetry systems. Detectors were calibrated in terms of absorbed dose to water in (60)Co gamma-ray and 6 MV x-ray reference (10×10 cm(2)) fields using an ionization chamber calibrated at a standards laboratory. Absorbed dose to water rate computed with MD-V2-55 was higher than that obtained with the others dosimeters, possibly due to a smaller volume averaging effect. Ratio between the dose-rates determined with each dosimeter and those obtained with the film was evaluated for both treatment modalities. For the LGK, the ratio decreased as the dosimeter size increased and remained constant for collimator diameters larger than 8 mm. The same behaviour was observed for the linac and the ratio increased with field size, independent of the dosimeter used. These behaviours could be explained as an averaging volume effect due to dose gradient and lack of electronic equilibrium. Evaluation of the output factors for the LGK collimators indicated that, even when agreement was observed between Monte Carlo simulation and measurements with different dosimeters, this does not warrant that the absorbed dose to water rate in the field was properly known and thus, investigation of the reference dosimetry should be an important issue. These results indicated that alanine dosimeter provides a high degree of accuracy but cannot be used in fields smaller than 20 mm diameter. Gafchromic film can be considered as a suitable methodology for reference dosimetry. TLD dosimeters are not appropriate in fields smaller than 10 mm diameters.
Assuntos
Dosimetria Fotográfica/métodos , Radiometria/métodos , Radiocirurgia/métodos , Alanina , Calibragem , Radioisótopos de Cobalto , Dosimetria Fotográfica/normas , Humanos , Doses de Radiação , Radiometria/normas , Radiocirurgia/instrumentação , Dosagem Radioterapêutica , Planejamento da Radioterapia Assistida por Computador/instrumentação , Planejamento da Radioterapia Assistida por Computador/métodos , Reprodutibilidade dos Testes , Água , Raios XRESUMO
The development of new medical devices possess a number of challenges, including designing, constructing, and assaying prototypes. In the case of new brachytherapy seeds, this is also true. In this paper, a methodology for rapid dosimetric characterization of (125)I brachytherapy seeds during the early stages of their development is introduced. The characterization methodology is based on the joint use of radiochromic and personal monitoring photographic films in order to determine the planar anisotropy due to the radiation field produced by the seed under development, by means of isodose curves. To evaluate and validate the process, isodose curves were obtained with both types of films after irradiation with a commercial (125)I brachytherapy seed.
Assuntos
Braquiterapia/métodos , Anisotropia , Braquiterapia/instrumentação , Dosimetria Fotográfica/métodos , Dosimetria Fotográfica/estatística & dados numéricos , Humanos , Radioisótopos do Iodo/uso terapêutico , Radiometria/métodos , Radiometria/estatística & dados numéricos , Dosagem RadioterapêuticaRESUMO
The feasibility of using radiochromic films to verify the metrological coherence among standard beta radiation fields was evaluated. Exercises were done between two Brazilian metrology laboratories in beta fields from (90)Sr/(90)Y, (85)Kr and (147)Pm radiation sources. Results showed that the radiochromic film was useful for field mapping aiming uniformity and alignment verification and it was not reliable for absorbed dose measurements only for (147)Pm beta field.
Assuntos
Partículas beta , Dosimetria Fotográfica/métodos , Calibragem , Estudos de Viabilidade , Radioisótopos de Criptônio , Promécio , Radioisótopos de Estrôncio , Radioisótopos de ÍtrioRESUMO
Instituto de Radioproteção e Dosimetria, a Brazilian government research institute, provides individual monitoring services since 1972. Its dosemeters are: film-based thorax for whole body photons, thermoluminescence dosimetry (TLD) albedo for whole body neutrons and TLD ring for extremity photons. About 6000 radiation workers are currently being monitored with film dosemeters in 256 different facilities in Brazil, most of them working in health-related activities. Around 400 Brazilian radiation workers are monitored with TLD albedo neutron monitor and about 500 workers use TLD rings. This paper describes the monitoring systems used, presents the results obtained in internal quality programs and in intercomparison exercises and analyses the measured dose values from 1985 to 2009.
Assuntos
Dosimetria Fotográfica/normas , Exposição Ocupacional/prevenção & controle , Monitoramento de Radiação/normas , Proteção Radiológica/normas , Radiometria/normas , Dosimetria Termoluminescente/normas , Acreditação , Bases de Dados Factuais , Desenho de Equipamento , Dosimetria Fotográfica/métodos , Órgãos Governamentais , História do Século XX , História do Século XXI , Humanos , Nêutrons , Centrais Nucleares , Controle de Qualidade , Monitoramento de Radiação/história , Proteção Radiológica/história , Radiometria/história , Dosimetria Termoluminescente/métodosRESUMO
This work reports the use of both GafChromic EBT film immersed in a water phantom and Monte Carlo (MC) simulations for small photon beam stereotactic radiosurgery dosimetry. Circularly collimated photon beams with diameters in the 4-20 mm range of a dedicated 6 MV linear accelerator (Novalis, BrainLAB, Germany) were used to perform off-axis ratios, tissue maximum ratios and total scatter factors measurements, and MC simulations. GafChromic EBT film data show an excellent agreement with MC results (<2.7%) for all measured quantities.
Assuntos
Método de Monte Carlo , Imagens de Fantasmas , Fótons , Radiometria/métodos , Água , Dosimetria Fotográfica/métodosRESUMO
The performance of an L-alanine dosimeter with millimeter dimensions was evaluated for dosimetry in small radiation fields. Relative output factor (ROF) measurements were made for 0.5 x 0.5, 1 x 1, 3 x 3, 5 x 5, 10 x 10 cm(2) square fields and for 5-, 10-, 20-, 40-mm-diam circular fields. In beam profile (BP) measurements, only 1 x 1, 3 x 3, 5 x 5 cm2 square fields and 10-, 20-, 40-mm-diam circular fields were used. For square and circular field irradiations, Varian/Clinac 2100, and a Siemens/Mevatron 6 MV linear accelerators were used, respectively. For a batch of 800 L-alanine minidosimeters (miniALAs) the average mass was 4.3+/-0.5 (1 sigma) mg, the diameter was 1.22+/-0.07 (1 sigma) mm, and the length was 3.5+/-0.2 (l sigma) mm. A K-Band (24 GHz) electron paramagnetic resonance (EPR) spectrometer was used for recording the spectrum of irradiated and nonirradiated miniALAs. To evaluate the performance of the miniALAs, their ROF and BP results were compared with those of other types of detectors, such as an ionization chamber (PTW 0.125 cc), a miniTLD (LiF: Mg,Cu,P), and Kodak/X-Omat V radiographic film. Compared to other dosimeters, the ROF results for miniALA show differences of up to 3% for the smallest fields and 7% for the largest ones. These differences were within the miniALA experimental uncertainty (-5-6% at 1 sigma). For BP measurements, the maximum penumbra width difference observed between miniALA and film (10%-90% width) was less than 1 mm for square fields and within 1-2 mm for circular fields. These penumbra width results indicate that the spatial resolution of the miniALA is comparable to that of radiographic film and its dimensions are adequate for the field sizes used in this experiment. The K-Band EPR spectrometer provided adequate sensitivity for assessment of miniALAs with doses of the order of tens of Grays, making this dosimetry system (K-Band/miniALA) a potential candidate for use in radiosurgery dosimetry.
Assuntos
Alanina/química , Espectroscopia de Ressonância de Spin Eletrônica/métodos , Dosimetria Fotográfica/instrumentação , Dosimetria Fotográfica/métodos , Imagens de Fantasmas , Radiometria/instrumentação , Radiometria/métodosRESUMO
PURPOSE: A procedure for the measurement of spatial dose rate distribution of beta particles emitted by 186Re-liposomes in tumoral tissue, using HS GafChromic films, is presented. METHODS: HNSCC xenografts were intratumorally injected with 3.7 or 11.1 MBq of 186Re-liposomes, and planar gamma camera images were acquired to determine the liposome retention in the tumor. After imaging, rats were sacrificed and tumors were excised and processed in slices; HS film sections were placed between slices and the tumor lobe was reassembled. Tumors and films were kept in the dark at 4 degrees C for 18 h. After irradiation, films were removed and response was read using a transmission scanner. Films were analyzed to determine two-dimensional spatial dose rate distributions and cumulative dose volume histograms. Dose rate distributions were quantified using a 60Co calibration curve, the 186Re physical half-life, and a perturbation factor that takes into account the effect of the film protective layer. RESULTS: Dose rate distributions are highly heterogeneous with maximal dose rates about 0.4 Gy h(-1) in tumors injected with 3.7 MBq and 1.3 Gy h(-1) in tumors injected with 11.1 MBq. Dose volume histograms showed dose distributed in more than 95% and 80% of the tumor when injected with the lower and the higher activity, respectively. CONCLUSION: The described procedures and techniques have shown the potential and utility of HS GafChromic film for determination of dose rate distributions in solid tumors injected intratumorally with 186Re-liposomes. The film's structure and the liposomes' biodistribution must be taken into account to obtain quantitative dose measurements.