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1.
Genet Mol Res ; 14(1): 952-60, 2015 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-25730033

RESUMO

This study aimed to investigate the therapeutic effects of craniocervical decompression with duraplasty and cerebellar tonsillectomy for the treatment of Chiari malformation-I with syringomyelia (CM I-SM). From January 2005 to December 2011, 127 patients with CM I-SM underwent craniocervical decompression with duraplasty and cerebellar tonsillectomy and the therapeutic effects of these surgeries were evaluated using Tator scores. No patient in this study died or showed disease deterioration after the surgery. Re-examination by magnetic resonance imaging (MRI) showed that the cisterna magna was obviously larger after the operation in all but one patient. Moreover, syringomyelia (SM) was reduced in 76 patients. CM I-SM symptoms disappeared or decreased in 112 patients after following discharge. Follow-up was conducted in 84 of the patients and 79 of these patients exhibited improved symptoms. A second MRI re-examination showed that the cisterna magna was successfully constructed in 44 patients; 42 of these patients showed further eliminated or obviously reduced SM. Craniocervical decompression with duraplasty and cerebellar tonsillectomy achieved favorable therapeutic effects. Thus, craniocervical decompression with duraplasty and cerebellar tonsillectomy is a rational surgical approach with beneficial clinical effects. The proposed approach may have useful applications in the treatment of CM I-SM.


Assuntos
Malformação de Arnold-Chiari/cirurgia , Cerebelo/cirurgia , Descompressão Cirúrgica/métodos , Dura-Máter/cirurgia , Siringomielia/cirurgia , Adolescente , Adulto , Idoso , Malformação de Arnold-Chiari/diagnóstico por imagem , Malformação de Arnold-Chiari/fisiopatologia , Cerebelo/diagnóstico por imagem , Cerebelo/fisiopatologia , Dura-Máter/diagnóstico por imagem , Dura-Máter/fisiopatologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Radiografia , Siringomielia/diagnóstico por imagem , Siringomielia/fisiopatologia , Tonsilectomia , Resultado do Tratamento
2.
Genet Mol Res ; 13(4): 10501-9, 2014 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-25511033

RESUMO

The objective of this study was to examine the clinical findings, magnetic resonance imaging (MRI), pathological features, and treatment experiments of patients with hypertrophic cranial pachymeningitis (HCP). The clinical findings, MRI, and pathological appearances of 9 patients with HCP were analyzed retrospectively. The thickened dura mater was markedly enhanced after contrast media injection. The lesion near the brain hemisphere presented long regions of T1- and T2-weighted abnormal signal intensities. The abnormal signal intensities of the brain tissue were decreased significantly. Pathological examination demonstrated chronic inflammation changes, with cerebral dura mater fibrous tissue showing obvious hyperplasia, and the periphery of the blood vessel showing a great quantity of infiltrating phlegmonosis cells. HCP mainly presents headache and paralysis of multiple cranial nerves. The distinctive signs on brain MRIs involve strengthening the signal in the cerebral dura.


Assuntos
Dura-Máter/diagnóstico por imagem , Imageamento por Ressonância Magnética , Meningite/diagnóstico por imagem , Adulto , Angiografia , Nervos Cranianos/diagnóstico por imagem , Nervos Cranianos/fisiopatologia , Dura-Máter/fisiopatologia , Feminino , Cefaleia/fisiopatologia , Humanos , Masculino , Meningite/fisiopatologia , Pessoa de Meia-Idade
3.
Acta Neurochir (Wien) ; 150(11): 1167-76, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18936878

RESUMO

BACKGROUND: Failed-back surgery syndrome remains a challenge for spinal surgeons. It can be related to several causes, including poor surgical indication, misdiagnosis, surgical technique failure, spondilodiscitis and fibrosis. Fibrosis has been associated with a poorer outcome in lumbar disc surgery, although its role in the generation of symptoms is not yet clear. In this study, the authors have analyzed any possible correlation between the clinical outcome and the degree of fibrosis. METHOD: Forty consecutive patients were enrolled in a prospective study. All of them had operations in the lower lumbar disc in a single level for the first time. Three months after the operation they were submitted to clinical outcome evaluations and questionnaires, including Numeric Pain Rating scales (NPR) for lumbar and leg pain, the McGill Pain Questionnaire, The Quebec Back Pain Disability scale (QBPD) and Straight Leg Raising test. These data were correlated with the degree of fibrosis as revealed by Magnetic Resonance Imaging (MRI). FINDINGS: After 3 months, the NPR values for lumbar and leg pain ranged from 0 to 8 (mean 2.32 and 1.67 respectively). The values of the post-operative QBPD scale ranged from 1 to 71 (mean 25.9). Every patient showed a varied degree of fibrosis on MRI. However, statistical analysis depicted no significant correlation between fibrosis and a poorer clinical outcome for pain and disability. CONCLUSIONS: The authors found no correlation between excessive fibrosis with lumbar and leg pain, disability or straight leg resistance. The role of fibrosis in the generation of symptoms in patients who have had lumbar disc surgery should be reevaluated.


Assuntos
Discotomia/efeitos adversos , Síndrome Pós-Laminectomia/epidemiologia , Fibrose/epidemiologia , Deslocamento do Disco Intervertebral/cirurgia , Complicações Pós-Operatórias/epidemiologia , Canal Medular/cirurgia , Adulto , Idoso , Cicatriz/epidemiologia , Cicatriz/patologia , Cicatriz/fisiopatologia , Dura-Máter/patologia , Dura-Máter/fisiopatologia , Dura-Máter/cirurgia , Síndrome Pós-Laminectomia/patologia , Síndrome Pós-Laminectomia/fisiopatologia , Feminino , Fibrose/patologia , Fibrose/fisiopatologia , Humanos , Incidência , Deslocamento do Disco Intervertebral/patologia , Vértebras Lombares , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde/métodos , Medição da Dor , Complicações Pós-Operatórias/patologia , Complicações Pós-Operatórias/fisiopatologia , Estudos Prospectivos , Reoperação/estatística & dados numéricos , Canal Medular/patologia , Raízes Nervosas Espinhais/patologia , Raízes Nervosas Espinhais/fisiopatologia , Raízes Nervosas Espinhais/cirurgia , Falha de Tratamento , Adulto Jovem
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