RESUMO

We describe an unusual case of prostatitis caused by Streptococcus canis evolving to endocarditis and splenic, renal, and cerebral thromboembolism in a dog, associated with a Sertoli cell tumour in a cryptic testis and diffuse prostatic squamous metaplasia. A nine-year-old, intact male, mixed-breed dog was presented to a veterinary teaching hospital with abdominal pain and prostration. Physical examination and abdominal ultrasonography revealed an atrophic right testicle located in the subcutaneous tissue. The left testicle was in the abdominal cavity with increased dimensions and irregular contours. Complete blood count analysis showed marked neutrophilic leukocytosis and thrombocytopenia. After clinical worsening, euthanasia was performed, and the dog was submitted to post-mortem examination. The main gross findings included testicular malposition with one cryptic and one ectopic testis, enlarged prostate with purulent content, distension of the urinary bladder with cloudy urine, vegetative valvular endocarditis in the mitral valve, and spleen and renal infarcts. Histological examination showed a Sertoli cell tumour in the abdominal testis, diffuse prostatic squamous metaplasia with marked keratinization associated with bacterial prostatitis, fibrinonecrotic cystitis, bacterial endocarditis with marked myxomatous degeneration in the mitral valve, and splenic, renal, and cerebral thromboembolism. Microbiological analysis identified Streptococcus canis in the prostate and mitral valve. Sertoli cell tumour of cryptic testis increases oestrogen production and leads to squamous metaplasia of the prostate, which should be considered as predisposing factors for ascending S. canis infection from the urogenital tract to the prostate. Then, haematogenous spread of S. canis from the prostate to mitral valve cause endocarditis and subsequent thromboembolism and infarcts, all decisive to poor prognosis in this case.

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A 4-year-old cow with a history of breathing difficulty, progressive weight loss, and muffled heart sound was treated for a period of two weeks, but died and underwent necropsy examination. Macroscopic examination revealed heart with vegetative proliferative lesion firmly adhered to pulmonary valve, lungs with marked consolidation, and the presence of thrombus in vessels. There were grade II ulcers in abomasal mucosa associated to blood clots. Microscopic examination revealed marked thickening of the pulmonary valve due to the proliferation of fibrous connective tissue, inflammatory neutrophil infiltration, fibrin deposition, and a significant number of coccoid basophilic bacteria. Septic thromboemboli were present in the large and small pulmonary blood vessels suggestive of embolic pneumonia. The bacterial culture of the valve showed growth of small, nonhemolytic colonies that demonstrated satellitism to coagulase-negative staphylococci contaminating colonies, which were subjected to 16S gene sequencing and were compatible with Helcococcus ovis in GenBank. This was the first report of H. ovis endocarditis in cattle in South America.(AU)

Um bovino, fêmea, 4 anos com histórico de dificuldade respiratória, perda de peso progressiva e som cardíaco abafado, foi tratado por um período de duas semanas, porém veio a óbito e foi submetido a exame de necropsia. No exame macroscópico, notou-se coração com lesão proliferativa vegetativa firmemente aderida em valva pulmonar, pulmões com consolidação acentuada, e presença de trombos no interior de vasos. Havia ainda úlcera abomasal grau II em mucosa associada a coágulo sanguíneo. No exame microscópico notou-se acentuado espessamento da valva pulmonar por proliferação de tecido conjuntivo fibroso, infiltrado inflamatório de neutrófilos, deposição de fibrina e acentuado número de miríades bacterianas basofílicas cocoides. Tromboembolia séptica foi vista no interior de vasos pulmonares de pequeno e médio calibre, sugestivo de pneumonia embólica. Em cultivo bacteriano da valva notou-se crescimento de colônias pequenas, não hemolíticas que demonstravam satelitismo a colônias contaminantes de estafilococos coagulase negativa, essas foram submetidas ao sequenciamento do gene 16S e foram compatíveis com Helcococcus ovis no GenBank. Este foi o primeiro relato de endocardite por H. ovis em bovino na América do Sul.(AU)

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Abstract We report the first documented case of endocarditis associated with Bartonella clarridgeiae in a dog in Latin America. Infective vegetative valvular aortic endocarditis was diagnosed in a 10-year-old male mixed breed dog. The dog presented grade V/VI systolic and diastolic murmur, hyperthermia, and progressive weight loss. Cardiomegaly and presence of diffuse alveolar pattern in the lung fields were observed in the thorax radiography evaluation. Irregular and hyperechogenic structures adhered to the aortic leaflets, causing obstruction of the left ventricular outflow tract and severe aortic insufficiency, were observed in the echocardiography evaluation. A vegetative, whitish, hardened structure measuring 1.0 cm in diameter was observed in aortic semilunar valve at necropsy. Based on a combination of pre-enrichment insect-based medium liquid culture, quantitative real-time and conventional PCR assays based on nuoG and gltA genes, respectively, followed by sequencing and phylogenetic inferences, B. clarridgeiae DNA was detected in the patient's aortic valve lesions. Clinical, echocardiographic, anatomopathologic and molecular features supported the diagnosis of severe aortic vegetative endocarditis possibly caused by B. clarridgeiae in a dog in Brazil.

Resumo Relatamos o primeiro caso documentado de endocardite associada à Bartonella clarridgeiae em um cão na América Latina. Endocardite aórtica valvar vegetativa infecciosa foi diagnosticada em um cão sem raça definida de 10 anos de idade. O cão apresentou sopro sistólico e diastólico de grau V / VI, hipertermia e perda progressiva de peso. Cardiomegalia e presença de padrão alveolar difuso nos campos pulmonares foram observados na avaliação radiográfica do tórax. Estruturas irregulares e hiperecogênicas aderidas aos folhetos aórticos, causando obstrução da via de saída do ventrículo esquerdo e insuficiência aórtica grave, foram observadas na avaliação ecocardiográfica. À necropsia, foi observada uma estrutura vegetativa, esbranquiçada e endurecida medindo 1,0 cm de diâmetro na válvula semilunar aórtica. Por meio de uma combinação de cultura líquida baseada em meio de pré-enriquecimento de inseto, ensaios de PCR quantitativa em tempo real e convencional baseados nos genes nuoG e gltA, respectivamente, seguidos de sequenciamento e inferências filogenéticas, DNA de B. clarridgeiae foi detectado no tecido valvular lesionado do paciente. O diagnóstico de endocardite vegetativa aórtica grave, possivelmente causado por B. clarridgeiae em um cão no Brasil, foi apoiado por características clínicas, ecocardiográficas, anatomopatológicas e moleculares.

Assuntos

RESUMO

We report the first documented case of endocarditis associated with Bartonella clarridgeiae in a dog in Latin America. Infective vegetative valvular aortic endocarditis was diagnosed in a 10-year-old male mixed breed dog. The dog presented grade V/VI systolic and diastolic murmur, hyperthermia, and progressive weight loss. Cardiomegaly and presence of diffuse alveolar pattern in the lung fields were observed in the thorax radiography evaluation. Irregular and hyperechogenic structures adhered to the aortic leaflets, causing obstruction of the left ventricular outflow tract and severe aortic insufficiency, were observed in the echocardiography evaluation. A vegetative, whitish, hardened structure measuring 1.0 cm in diameter was observed in aortic semilunar valve at necropsy. Based on a combination of pre-enrichment insect-based medium liquid culture, quantitative real-time and conventional PCR assays based on nuoG and gltA genes, respectively, followed by sequencing and phylogenetic inferences, B. clarridgeiae DNA was detected in the patient's aortic valve lesions. Clinical, echocardiographic, anatomopathologic and molecular features supported the diagnosis of severe aortic vegetative endocarditis possibly caused by B. clarridgeiae in a dog in Brazil.

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RESUMO

Foi atendido um paciente canino, fêmea, apresentando endocardite da válvula mitral, doença periodontal severa e diabetes mellitus. A endocardite infecciosa é uma doença com baixa taxa de morbidade, porém, com alta taxa de mortalidade. É uma infecção do endocárdio que surge como consequência de uma bacteremia transitória ou permanente. A doença periodontal tem sido incriminada como responsável por bacteremia e fator de risco para a endocardite e resistência à insulina. O estado diabético é considerado um fator agravante para a endocardite e para a doença periodontal pelo comprometimento de várias funções do organismo, inclusive a resposta imune e integridade vascular. O diagnóstico da endocardite geralmente é realizado na necropsia e quando feito na clínica médica, o tratamento é bastante agressivo, prolongado e muitas vezes frustrante. O objetivo do presente trabalho é de relatar o diagnóstico e o sucesso do tratamento de um paciente com endocardite de mitral.(AU)

A canine female patient was treated with mitral valve endocarditis, severe periodontal disease and diabetes mellitus. Infective endocarditis is a disease with a low morbidity rate, but with a high mortality rate. It is an endocardial infection that arises as a consequence of transient or permanent bacteremia. Periodontal disease has been incriminated as responsible for bacteremia and risk factor for endocarditis and insulin resistance. The diabetic state is considered an aggravating factor for endocarditis and periodontal disease due to the impairment of various functions of the organism, including immune response and vascular integrity. The diagnosis of endocarditis is usually performed at necropsy and when done at the medical clinic, the treatment is quite aggressive, prolonged and often frustrating. The aim of this study is to report the diagnosis and success of the treatment of a patient with mitral endocarditis.(AU)

Se atendió a un paciente canino, hembra, presentando endocarditis de la válvula mitral, enfermedad periodontal varias y diabetes mellitus. La endocarditis infecciosa es una enfermedad con baja tasa de morbilidad, pero con alta tasa de mortalidad. Es una infección del endocardio que surge como consecuencia de una bacteriemia transitoria o permanente. La enfermedad periodontal ha sido incriminada como fuese por bacteremia y factor de riesgo para la endocarditis y resistencia a la insulina. El estado diabético se considera un factor agravante para la endocarditis y para la enfermedad periodontal por el compromiso de varias funciones del organismo, incluyendo la respuesta inmune e integridad vascular. El diagnóstico de la endocarditis generalmente se realiza en la necropsia y cuando se hace en la clínica médica, el tratamiento es bastante agresivo, prolongado y muchas veces frustrante. El objetivo del presente trabajo es relatar el diagnóstico y el éxito del tratamiento de un paciente con endocarditis de mitral.(AU)

Assuntos

RESUMO

Foi atendido um paciente canino, fêmea, apresentando endocardite da válvula mitral, doença periodontal severa e diabetes mellitus. A endocardite infecciosa é uma doença com baixa taxa de morbidade, porém, com alta taxa de mortalidade. É uma infecção do endocárdio que surge como consequência de uma bacteremia transitória ou permanente. A doença periodontal tem sido incriminada como responsável por bacteremia e fator de risco para a endocardite e resistência à insulina. O estado diabético é considerado um fator agravante para a endocardite e para a doença periodontal pelo comprometimento de várias funções do organismo, inclusive a resposta imune e integridade vascular. O diagnóstico da endocardite geralmente é realizado na necropsia e quando feito na clínica médica, o tratamento é bastante agressivo, prolongado e muitas vezes frustrante. O objetivo do presente trabalho é de relatar o diagnóstico e o sucesso do tratamento de um paciente com endocardite de mitral.

A canine female patient was treated with mitral valve endocarditis, severe periodontal disease and diabetes mellitus. Infective endocarditis is a disease with a low morbidity rate, but with a high mortality rate. It is an endocardial infection that arises as a consequence of transient or permanent bacteremia. Periodontal disease has been incriminated as responsible for bacteremia and risk factor for endocarditis and insulin resistance. The diabetic state is considered an aggravating factor for endocarditis and periodontal disease due to the impairment of various functions of the organism, including immune response and vascular integrity. The diagnosis of endocarditis is usually performed at necropsy and when done at the medical clinic, the treatment is quite aggressive, prolonged and often frustrating. The aim of this study is to report the diagnosis and success of the treatment of a patient with mitral endocarditis.

Se atendió a un paciente canino, hembra, presentando endocarditis de la válvula mitral, enfermedad periodontal varias y diabetes mellitus. La endocarditis infecciosa es una enfermedad con baja tasa de morbilidad, pero con alta tasa de mortalidad. Es una infección del endocardio que surge como consecuencia de una bacteriemia transitoria o permanente. La enfermedad periodontal ha sido incriminada como fuese por bacteremia y factor de riesgo para la endocarditis y resistencia a la insulina. El estado diabético se considera un factor agravante para la endocarditis y para la enfermedad periodontal por el compromiso de varias funciones del organismo, incluyendo la respuesta inmune e integridad vascular. El diagnóstico de la endocarditis generalmente se realiza en la necropsia y cuando se hace en la clínica médica, el tratamiento es bastante agresivo, prolongado y muchas veces frustrante. El objetivo del presente trabajo es relatar el diagnóstico y el éxito del tratamiento de un paciente con endocarditis de mitral.

Assuntos

RESUMO

We report the first documented case of endocarditis associated with Bartonella clarridgeiae in a dog in Latin America. Infective vegetative valvular aortic endocarditis was diagnosed in a 10-year-old male mixed breed dog. The dog presented grade V/VI systolic and diastolic murmur, hyperthermia, and progressive weight loss. Cardiomegaly and presence of diffuse alveolar pattern in the lung fields were observed in the thorax radiography evaluation. Irregular and hyperechogenic structures adhered to the aortic leaflets, causing obstruction of the left ventricular outflow tract and severe aortic insufficiency, were observed in the echocardiography evaluation. A vegetative, whitish, hardened structure measuring 1.0 cm in diameter was observed in aortic semilunar valve at necropsy. Based on a combination of pre-enrichment insect-based medium liquid culture, quantitative real-time and conventional PCR assays based on nuoG and gltA genes, respectively, followed by sequencing and phylogenetic inferences, B. clarridgeiae DNA was detected in the patients aortic valve lesions. Clinical, echocardiographic, anatomopathologic and molecular features supported the diagnosis of severe aortic vegetative endocarditis possibly caused by B. clarridgeiae in a dog in Brazil.(AU)

Relatamos o primeiro caso documentado de endocardite associada à Bartonella clarridgeiae em um cão na América Latina. Endocardite aórtica valvar vegetativa infecciosa foi diagnosticada em um cão sem raça definida de 10 anos de idade. O cão apresentou sopro sistólico e diastólico de grau V / VI, hipertermia e perda progressiva de peso. Cardiomegalia e presença de padrão alveolar difuso nos campos pulmonares foram observados na avaliação radiográfica do tórax. Estruturas irregulares e hiperecogênicas aderidas aos folhetos aórticos, causando obstrução da via de saída do ventrículo esquerdo e insuficiência aórtica grave, foram observadas na avaliação ecocardiográfica. À necropsia, foi observada uma estrutura vegetativa, esbranquiçada e endurecida medindo 1,0 cm de diâmetro na válvula semilunar aórtica. Por meio de uma combinação de cultura líquida baseada em meio de pré-enriquecimento de inseto, ensaios de PCR quantitativa em tempo real e convencional baseados nos genes nuoG e gltA, respectivamente, seguidos de sequenciamento e inferências filogenéticas, DNA de B. clarridgeiae foi detectado no tecido valvular lesionado do paciente. O diagnóstico de endocardite vegetativa aórtica grave, possivelmente causado por B. clarridgeiae em um cão no Brasil, foi apoiado por características clínicas, ecocardiográficas, anatomopatológicas e moleculares.(AU)

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A case of bacterial (Pseudomonas aeruginosa) valvular endocarditis in a red-billed curassow is described. A traumatic fracture in one limb of the bird was considered the port of entry for the bacterium, followed by septicemia and seeding of the heart valve. Brain embolism resulting from detached thrombus fragments followed.

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RESUMO

A case of bacterial (Pseudomonas aeruginosa) valvular endocarditis in a red-billed curassow is described. A traumatic fracture in one limb of the bird was considered the port of entry for the bacterium, followed by septicemia and seeding of the heart valve. Brain embolism resulting from detached thrombus fragments followed.(AU)

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RESUMO

Background: Aortic thromboembolism (ATE) is a potentially fatal and rare condition in dogs. Ischemic neuromyopathy is main consequence, characterized by paraparesis or paraplegia, loss of femoral pulses, pain and hypothermia in distal part of affected limbs. In felines, affection is primarily associated with heart problems, whereas in dogs, condition is due to diseases which compromise the blood flow, such as, hyperadrenocorticism, immune-mediated hemolytic anemia, disseminated intravascular coagulation, sepsis, and more rarely cardiac problems. The aim of this article is describe a case of acute aortic thromboembolism due to bacterial endocarditis in a dog. Case: A female, 9-year-old dog, weighing 28.5 kg, was referred for examination due to acute paraparesis and pain. Patient showed cyanosis in nail beds and cold extremities in hind limbs, heart murmur degree V / IV, and bilateral absence of femoral arterial pulse. Due to suspicion of ATE, patient was treated with heparin, aspirin and tramadol, however it came to die less than 24 h after initial care. At necropsy, there was pulmonary edema, moderate hyperemia and severe tricuspid mitral valve. A thrombus with 3.0 cm of diameter in left atrium was found. At beginning of aorta there was also a thrombus measuring 5.0 cm x 0.3 cm x 0.3 cm and other thrombus in abdominal aortic trifurcation measuring 3.0 cm x 0.5 cm x 0.5 cm. [...](AU)

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