RESUMO
La hipertensión arterial es una de las enfermedades crónicas de mayor incidencia a nivel mundial, produce una importante mortalidad y discapacidad. Este trabajo tuvo por objetivo evaluar el efecto del uso de mensajes de texto en dispositivos de telefonía móvil en la adherencia al tratamiento de hipertensión arterial. Se efectuó un estudio de intervención cuasiexperimental, de antes y después, en el cual se entrevistó a pacientes que pertenecían a un programa ambulatorio de enfermedades crónicas. Se formaron 4 grupos, uno de ellos, el grupo control. A los grupos intervenidos se les remitieron mensajes de texto (educativos/motivadores), con diferentes frecuencias de envío, por un período de 2 meses. Al término de la intervención, se pidió llenar el cuestionario Martín-Bayarre-Grau para determinar su adherencia al tratamiento antihipertensivo antes y después de la intervención. Se realizó un análisis bivariado, en el cual se comparó la variable adherencia al tratamiento, antes y después de la intervención, de los cuatro grupos del estudio. Se encontró solo una diferencia significativa en el grupo 3 (p = 0,011), al cual se le enviaron 8 mensajes al mes (2 por semana). También se comparó, después de los 2 meses, a los grupos sometidos a intervención versus el grupo control; se halló una diferencia significativa en el grupo 3 (p = 0,022). La intervención ha demostrado ser útil para mejorar la adherencia en esta población de estudio. Se obtuvo una respuesta positiva en el grupo 3, que recibió 8 mensajes al mes(AU)
Hypertension is one of the chronic diseases with the highest incidence worldwide and a cause of considerable mortality and disability. This paper aims to evaluate the effect of mobile phone text messaging on adherence to hypertension treatment. A quasi-experimental before-after intervention was conducted based on interviews with patients from a chronic disease outpatient program. Four groups were formed, one of which was the control group. The groups intervened were sent encouraging educational text messages at varying frequencies for a period of two months. At the close of the intervention, participants were asked to fill in the Martín Bayarre Grau questionnaire to determine their adherence to antihypertensive treatment before and after the intervention. A bivariate analysis was performed comparing the variable adherence to treatment before and after the intervention in the four study groups. A significant difference was only found in Group 3 (p = 0.011). This group was sent eight messages per month (two messages per week). Additionally, a comparison between the intervention groups and the control group conducted at two months found a significant difference in Group 3 (p = 0.022). The intervention proved was useful to improve adherence in the study population. A positive response was obtained in Group 3, who received eight messages per month(AU)
Assuntos
Humanos , Masculino , Feminino , Fatores de Risco , Telefone Celular , Envio de Mensagens de Texto , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Cooperação e Adesão ao Tratamento/psicologia , Hipertensão/epidemiologiaRESUMO
BACKGROUND: Anal fistula treatment aims to eradicate the fistula, preserve the sphincter, prevent recurrence, and allow an early return to daily activities for the patient. Because of the difficulty of achieving these goals, stem cell-based therapy has emerged for the treatment of complex perianal fistula with promising results. OBJECTIVE: The objective of this study was to evaluate the safety of allogeneic mesenchymal stem cells in the treatment of complex anal fistula in patients without Crohn's disease. DESIGN: This was a prospective nonrandomized phase I clinical trial. SETTINGS: This study was conducted at a second-level hospital. PATIENTS: Twenty consecutive patients diagnosed with a complex fistula were included. INTERVENTIONS: All patients received 40 × 106 allogeneic mesenchymal stem cells. In patients with 2 tracts, 20 × 106 stem cells were applied on each tract. MAIN OUTCOME MEASURES: The patients were discharged 24 hours after the procedure and were evaluated at 1, 2, 4, 8, 16, and 24 weeks after the application. The long-term follow-up was performed 1 year after the procedure. RESULTS: The procedure was performed in a total of 20 patients from October 1, 2016, to October 31, 2017; 1 patient was eliminated from the final data analysis. No adverse effects were reported within the first 24 hours, and all the patients were discharged asymptomatic. Three patients (15%) presented with perianal abscess. In 1 patient, the abscess appeared at the fourth week, and, in the other 2 patients, the abscess was diagnosed at week 8. Complete closure was achieved in 13 (69%) patients. LIMITATIONS: This was a nonrandomized controlled trial. CONCLUSION: The use of allogeneic mesenchymal stem cells as a treatment is a safe option for the management of complex perianal fistula not associated with Crohn's disease. See Video Abstract at http://links.lww.com/DCR/B443. SEGURIDAD DE LAS CLULAS MADRE MESENQUIMALES ALOGNICAS DERIVADAS DEL TEJIDO ADIPOSO PARA EL TRATAMIENTO DE FSTULAS PERIANALES COMPLEJAS NO ASOCIADAS CON LA ENFERMEDAD DE CROHN ENSAYO CLNICO DE FASE I: ANTECEDENTES:El tratamiento de la fístula anal tiene como objetivo erradicar la fístula, preservar el esfínter, prevenir la recurrencia y permitir un retorno temprano a las actividades diarias del paciente. Debido a la dificultad de alcanzar estos objetivos, ha surgido una terapia basada en células madre para el tratamiento de la fístula perianal compleja con resultados prometedores.OBJETIVO:El objetivo de este estudio fue evaluar la seguridad de las células madre mesenquimales alogénicas en el tratamiento de la fístula anal compleja en pacientes sin enfermedad de Crohn.DISEÑO:Este fue un ensayo clínico prospectivo no aleatorizado de fase I.AMBIENTE:Este estudio se realizó en un hospital de segundo nivel.PACIENTES:Veinte pacientes consecutivos diagnosticados de fístula compleja.INTERVENCIONES:Todos los pacientes recibieron 40 x 106 células madre mesenquimales alogénicas, en pacientes con dos tractos, se aplicaron 20 x 106 células madre en cada tracto.PRINCIPALES MEDIDAS DE RESULTADO:Los pacientes fueron dados de alta 24 horas después del procedimiento y fueron evaluados 1, 2, 4, 8, 16, 24 semanas después de la aplicación. El seguimiento a largo plazo se realizó un año después del procedimiento.RESULTADOS:El procedimiento se realizó en un total de 20 pacientes desde el 1 de octubre de 2016 al 31 de octubre de 2017; un paciente fue eliminado del análisis de datos final. No se informaron efectos adversos en las primeras 24 horas, todos los pacientes fueron dados de alta asintomáticos. Tres pacientes (15%) presentaron absceso perianal. En un paciente, el absceso apareció a la cuarta semana y en los otros dos pacientes el absceso se diagnosticó en la octava semana. El cierre completo se logró en 13 (69%) de los pacientes.LIMITACIONES:Este fue un ensayo controlado no aleatorio.CONCLUSIÓN:El uso de células madre mesenquimales alogénicas como tratamiento es una opción segura para el manejo de la fístula perianal compleja no asociada con la enfermedad de Crohn. Consulte Video Resumen en http://links.lww.com/DCR/B443.
Assuntos
Doenças do Ânus/microbiologia , Transplante de Células-Tronco Mesenquimais/métodos , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Fístula Retal/terapia , Abscesso/diagnóstico , Abscesso/epidemiologia , Adulto , Células Alógenas , Doenças do Ânus/patologia , Feminino , Seguimentos , Humanos , Incidência , Masculino , Transplante de Células-Tronco Mesenquimais/efeitos adversos , Células-Tronco Mesenquimais , Pessoa de Meia-Idade , Estudos Prospectivos , Fístula Retal/patologia , Segurança , Resultado do TratamentoRESUMO
Introducción: Los síntomas urinarios constituyen el motivo de consulta pediátrica más frecuente en relación con el aparato urinario durante cualquier época del año y a cualquier edad. Los argumentos para el uso o no de la quimioprofilaxis para evitar las recurrencias, son variables. Objetivo: Verificar la efectividad de la quimioprofilaxis para prevenir las recurrencias en la infección del tracto urinario en niños de 1 a 24 meses. Métodos: Se realizó un cuasi-experimento conformado por 58 pacientes que ingresaron en el Hospital Pediátrico de Holguín que cumplieron con los criterios de inclusión. Las variables de estudio fueron: número de recurrencias, momento de aparición durante la observación, presencia de recurrencia, quimioprofilaxis, tipo de quimioprofilaxis, edad, sexo, microorganismo aislado, factor predisponente, clasificación de riesgo. Se trabajó con 95 por ciento de confiabilidad lo que significó que valores de p por debajo de 0,05 fueron considerados como significativos. Se realizó el procesamiento en el programa SPSS versión 22.0. Resultados: De 58 pacientes estudiados solo tuvieron recurrencia 6,9 por ciento; de los que no recibieron quimioprofilaxis ninguno tuvo recurrencia y los que recibieron tratamiento quimioprofiláctico, 4 tuvieron recurrencia, por lo que haber recibido o no quimioprofilaxis no influyó en la aparición de recurrencia y menos después de 18 meses de una primera infección urinaria. Conclusiones: La presencia de recurrencias después de 18 meses de una primera infección urinaria en niños menores de 2 años no es un evento frecuente y parece que la quimioprofilaxis no es efectiva(AU)
Introduction: Urinary symptoms are the most frequent reason for pediatric consultation related to the urinary system during any time of the year and at any age. The arguments for the use or not of chemoprophylaxis to avoid recurrences are variable. Objective: Confirm the effectiveness of chemoprophylaxis to prevent recurrences of urinary tract infections in children aged 1 to 24 months. Methods: A quasi-experiment consisting of 58 patients admitted to the Children's Hospital of Holguín who met the inclusion criteria was conducted. The study variables were: number of recurrences, time of onset during observation, presence of recurrence, chemoprophylaxis, type of chemoprophylaxis, age, sex, isolated microorganism, predisposing factor, risk classification. We worked with 95 percent of reliability which meant that p values below 0.05 were considered significant. Processing was performed in the SPSS version 22.0 program. Results: From the 58 patients studied, only 6.9% had recurrence; of those who did not receive chemoprophylaxis none had recurrence and of those who received chemoprophylactic treatment, 4 had recurrence; so, having received or not chemoprophylaxis did not influence the appearance of recurrence and less after 18 months of a first urinary infection. Conclusions: The presence of recurrences after 18 months of a first urinary tract infection in children under 2 years of age is not a frequent event and it seems that chemoprophylaxis is not effective(AU)
Assuntos
Humanos , Lactente , Recidiva , Sistema Urinário/virologia , Resultado do Tratamento , Quimioprevenção/métodos , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodosRESUMO
Introducción: Los implantes postextractivos acortan el tiempo en lograr la rehabilitación del paciente, resulta esta condicionante un factor esencial para devolver la calidad de vida en corto plazo a un adulto mayor y mejorar rápidamente su función masticatoria. Objetivo: Determinar los valores de estabilidad y la pérdida ósea periimplantaria en implantes postextractivos en pacientes de la tercera edad. Material y Método: Se realizó un estudio cuasi-experimental en 99 pacientes de la tercera edad en la Facultad de Estomatología ¨Raúl González Sánchez¨, 2017-2019. Bajo su consentimiento se colocaron 173 implantes postextractivos. Se determinó tipo de hueso de soporte, estabilidad primaria y secundaria según análisis de frecuencia de resonancia con Osstel Mentor. Se midió el nivel óseo periimplantario y la pérdida ósea hasta 12 meses de colocada la rehabilitación. Resultados: Se posicionaron mayoritariamente implantes en el sitio de implantación incisivo maxilar en 43,3 por ciento de los casos. Los valores promedio de estabilidad primaria y secundaria fueron 48 ISQ y 68 ISQ respectivamente. La pérdida ósea promedio tras un año de rehabilitación fue de 1,04±0,22mm. Conclusiones: Los implantes dentales postextractivos en pacientes de la tercera edad se insertaron preferentemente en el grupo incisivo maxilar y en hueso tipo D2, registraron una estabilidad primaria promedio moderada y una estabilidad secundaria promedio substancial. La pérdida ósea vertical periimplantaria exhibió valores semejantes a los implantes en zonas curadas y dentro del valor estandarizado para pérdida ósea periimplantaria para el primer año tras su colocación(AU)
Introduction: Post-extractive implants shorten the time in achieving the rehabilitation of the patient, being this condition an essential factor to restore the quality of life to elderly patients at short term. Objective: To determine the stability values and peri-implant bone loss in post-extractive implants in elderly patients. Material and Method: A cohort study was carried out in 99 elderly patients at Raúl González Sánchez Dental School of Havana from 2017 to 2019. Under the consent of the patients, 173 post-extractive implants were placed. Bone support type, and primary and secondary stability were determined on the basis of a resonance frequency analysis with Ostell Mentor®. The peri-implant bone level and peri-implant bone loss were measured until 12 months after rehabilitation. Results: Implants were mainly positioned in the maxillary incisive site in 43,3 percent of the cases. The average values of primary and secondary stability were 48 ISQ and 68 ISQ, respectively. The average bone loss after 12 months of rehabilitation was 1,04 ± 0,22 mm. Conclusions: Post-extractive dental implants were inserted preferably in the maxillary incisive site and in D2 bone type, registering moderated average values of primary stability and substantial average values of secondary stability. The peri-implant vertical bone loss exhibited implants with similar values than those in the healed areas and within the standardized value for peri-implant bone loss within the first year after implant placement(AU)
Assuntos
Humanos , Idoso , Idoso de 80 Anos ou mais , Qualidade de Vida , Faculdades de Odontologia , Implantes Dentários , Medicina Bucal , Análise de Frequência de Ressonância , Estudos de Coortes , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodosRESUMO
Purpose: The objective of this study was to describe the short-term results of allogenic transplantation of limbal stem cells expanded on amniotic membrane for the ocular surface reconstruction. Methods: Prospective nonrandomized, nonmasked study in a single ophthalmological center. Ten patients with bilateral total limbal stem cell deficiency (LSCD) were included. Expression and presence of ABCB5 and Δp63α in amniotic membrane-cultured limbal epithelial stem cells were analyzed, in relationship with clinical changes after allogenic transplantation. An objective evaluation was performed to determine corneal transparency and superficial vascularization. Results: In a median follow-up time of 11.6 months, 7 patients (70%) were considered as failure compared with the preoperative status. ABCB5 and Δp63α are expressed in similar amount in the limbal epithelial cells expanded in vitro and transplanted in patients with bilateral LSCD. Conclusions: Transplantation of allogenic epithelial limbal cells expanded in amniotic membrane could be considered in patients with LSCD due to burns or congenital etiologies such as aniridia, but its benefit is limited for patients with immunologic diseases.
Assuntos
Âmnio/transplante , Doenças da Córnea/etiologia , Epitélio Corneano/transplante , Limbo da Córnea/patologia , Células-Tronco/citologia , Transplante Homólogo/métodos , Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo , Adolescente , Adulto , Âmnio/citologia , Âmnio/metabolismo , Aniridia/complicações , Estudos de Casos e Controles , Córnea/irrigação sanguínea , Córnea/metabolismo , Doenças da Córnea/diagnóstico , Doenças da Córnea/metabolismo , Doenças da Córnea/cirurgia , Lesões da Córnea/complicações , Epitélio Corneano/anormalidades , Epitélio Corneano/citologia , Epitélio Corneano/metabolismo , Feminino , Seguimentos , Humanos , Limbo da Córnea/citologia , Limbo da Córnea/metabolismo , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Estudos Prospectivos , Transplante de Células-Tronco/efeitos adversos , Células-Tronco/metabolismo , Células-Tronco/patologia , Fatores de Transcrição/metabolismo , Resultado do Tratamento , Proteínas Supressoras de Tumor/metabolismo , Adulto JovemRESUMO
Abstract Objective: To determine the effect of dental health education for teachers and parents on children aged 7-9 years old. Material and Methods: This was a quasi-experimental study with a nonrandomized control group and a pretest-posttest design. The intervention group comprised 20 teachers and 66 mothers, whereas the control group consisted of 10 teachers and 54 mothers. Data on the knowledge and behavior of teachers and mothers were retrieved by pretest and posttest questionnaires. The 66 children in the intervention group underwent a 16-surface tooth brushing program, whereas the 54 children in the control group were only provided theoretical education by their teachers and mothers. The evaluation was conducted after one month to measure the children's dental plaque index. Results: An increase in teachers' oral health knowledge (16.7%), teachers' oral health behavior (20%), mothers' oral health knowledge (16.7%), and mothers' oral health behavior (20%) was noted; the children's plaque index was decreased (47%). Conclusion: The dental health education of teachers and parents (mothers) supported by the 16-surface teeth brushing program resulted in a significant reduction in the dental plaque index in children aged 7-9 years old.
Assuntos
Humanos , Masculino , Feminino , Escovação Dentária , Conhecimentos, Atitudes e Prática em Saúde , Saúde Bucal/educação , Educação em Saúde Bucal , Indonésia/epidemiologia , Efetividade , Índice de Placa Dentária , Inquéritos e Questionários , Estatísticas não Paramétricas , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodosRESUMO
Experimental studies are used to assess the efficacy and effectiveness of therapeutic (pharmacological or surgical), preventive (such as vaccination or lifestyle changes) or educational interventions (e.g., workshops to improve quality and healthcare). There are different experimental studies but, currently, randomized controlled trial (RCT) is recognized as the type of study that provides the highest level of evidence. When this type of research cannot be carried out, there are quasi-experimental studies, where there may be no randomization or a control group; however, this type of studies has a lower degree of validity. This article describes the way different types of RCT and quasi-experimental studies are performed; their advantages and disadvantages are also explained.
Los estudios experimentales se utilizan para evaluar la eficacia y efectividad de una intervención terapéutica (farmacológica o quirúrgica), preventiva (como la vacunación o los cambios estilo de vida) o educativa (por ejemplo, taller para mejorar la calidad y la atención a la salud). Existen diferentes estudios experimentales, pero en la actualidad se reconoce que el ensayo clínico controlado y aleatorizado es el que brinda el mayor grado de evidencia. Cuando no se puede llevar a cabo este tipo de investigación se tienen disponibles los estudios cuasiexperimentales, en los cuales puede ser que no se realice aleatorización o no exista un grupo control, sin embargo, tienen un menor grado de validez. En este artículo se describe la forma de realizar los diferentes tipos de ensayo clínico controlado y aleatorizado y estudios cuasiexperimentales; también se exponen sus ventajas y desventajas.
Assuntos
Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Projetos de Pesquisa , HumanosRESUMO
Objetivo: Evaluar la efectividad de la estrategia educativa dirigida a adultos mayores diabéticos tipo 2 y proveedores de salud. Métodos: Investigación cuasi experimental que evaluó un antes-después con grupo control. El universo de estudio estuvo constituido por adultos mayores diabéticos dispensarizados en los policlínicos Hermanos Cruz (U= 1 369) y Pedro Borrás (U= 1 528), del primero se seleccionó el grupo experimental y en el segundo el grupo control, ambos del municipio y provincia Pinar del Río. Para determinar la muestra se utilizó un Muestreo por Conglomerados Bietápico con probabilidades proporcionales al tamaño de las Unidades de Primera Etapa quedando conformada para ambos grupos por 123 adultos mayores diabéticos tipo 2. Se trabajó con el universo de prestadores del GBT uno (U= 84) del policlínico Hermanos Cruz. La estrategia fue aplicada en el grupo experimental, y evaluada de forma inmediata, a los seis meses y al año. Resultados: Las comparaciones de los grupos en los momentos relacionados con la aplicación de la estrategia estuvieron dentro de lo esperado, generalmente se produjeron cambios significativos en los adultos mayores diabéticos tipo 2 en cuanto a los resultados globales y en cada una de las preguntas examinadas a favor del grupo experimental e igualmente en los proveedores de salud. Conclusiones: La mejoría detectada en los resultados de las variables de respuesta principal y secundarias, en el grupo experimental, dan una medida de la efectividad de la estrategia. Al mismo tiempo su estabilidad a los seis meses y al año considerado como horizonte temporal de evaluación, avalan su sostenibilidad(AU)
Objective: To evaluate the effectiveness of the educational strategy aimed at type 2 diabetic older adults and at health providers. Method: A quasi experimental research study to evaluate the situation before and after the application of this strategy in a control group. The study population consisted of diabetic old patients recruited at Hermanos Cruz (U= 1 369) and Pedro Borrás Astorga (U= 1 528) polyclinics. The experimental group was chosen from the first group and the control group from the second one, both in Pinar del Río municipality in Pinar del Rio province. A two-staged cluster was used with proportional probabilities according to the size of the first stage units and the final sample was 123 type 2 diabetic older adults for both groups. All the basic working team health providers from Hermanos Cruz polyclinics were involved in the study. The strategy was applied in the experimental group and immediately evaluated after six months and after a year. Results: The comparisons of the groups made at the time of the implementation of the strategy were within the expectations; there were significant changes in type 2 diabetics in terms of overall outcomes and each of the analyzed questions, which favored the experimental group along with the health providers. Conclusions: The improvement observed in the results of the answer variables of the experimental group shows the strategy effectiveness. At the same time, the stability of results after six months and a year endorses the strategy sustainability(AU))
Assuntos
Humanos , Masculino , Feminino , Educação de Pacientes como Assunto , Pessoal de Saúde/educação , Diabetes Mellitus Tipo 2 , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , CubaRESUMO
BACKGROUND: Over the past 20 years, solid organ transplantation has evolved from experimental treatments to an effective alternative for the treatment of various diseases, including heart failure. Treatment non-adherence is a limiting factor for the success of heart transplants. A systematic review of the evidence is needed to examine the effectiveness of interventions for managing adherence to treatment in heart transplant patients. OBJECTIVE: The primary objective of this systematic review was to synthesize the best available evidence regarding interventions for managing adherence to pharmacological and non-pharmacological treatments in heart/heart-lung transplant patients. INCLUSION CRITERIA: This review considered primary studies that included patients 18 years old or older, who had undergone heart or heart-lung transplantation (regardless of gender, ethnicity, comorbidities or whether they had received other treatments or not) who were receiving pharmacological and non-pharmacological treatments.This review considered studies that evaluated the effectiveness of interventions in managing adherence to pharmacological or non-pharmacological treatments among adult heart/heart-lung transplant patients. Primary studies comparing standard care with any type of intervention to maintain treatment adherence were considered.This review considered any experimental study design including randomized controlled trials; other research designs, such as non-randomized controlled trials and before and after studies, were also considered for inclusion.The primary outcome considered was patient adherence to pharmacological or non-pharmacological treatments by means of objective or self-report assessment. SEARCH STRATEGY: Published and unpublished studies in English, Portuguese and Spanish were searched in electronic databases. Searches were completed in January 2014. METHODOLOGICAL QUALITY: Two independent reviewers, using the standardized critical appraisal instruments from the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument, assessed methodological quality. DATA EXTRACTION: Data were extracted using the standardized data extraction tool from Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument. DATA SYNTHESIS: Statistical pooling was not possible due to substantial heterogeneity of the studies; therefore data were presented as a narrative summary. RESULTS: Three quasi-experimental studies were included in this review. One study found that a dose reduction of immunosuppressive medications from a twice-daily to a once-daily regimen had a positive impact on treatment adherence; one found no significant difference in treatment adherence between patients who received educational intervention conducted in a teaching laboratory and those who received standard care; the third one also reported no significant difference in outcomes between a multifaceted intervention consisting of internet-based interactive workshops and standard care. CONCLUSIONS: The current best evidence to guide decisions regarding interventions to manage treatment adherence in heart transplant patients is limited. There is weak evidence that psycho-educational interventions (other than the standard care) has a positive impact on adherence and that decreasing the complexity of the treatment regimen by reducing the daily dose of the immunosuppressant drug improves adherence in heart transplant patients.
Assuntos
Transplante de Coração/enfermagem , Adesão à Medicação/estatística & dados numéricos , Cooperação e Adesão ao Tratamento/estatística & dados numéricos , Adulto , Enfermagem Baseada em Evidências/métodos , Feminino , Transplante de Coração/educação , Humanos , Terapia de Imunossupressão/normas , Masculino , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Avaliação de Resultados em Cuidados de Saúde , Cooperação do Paciente/estatística & dados numéricos , Ensaios Clínicos Controlados Aleatórios como Assunto , AutorrelatoRESUMO
OBJECTIVE: Our goal was to assess the effects of weight loss on antioxidant enzymes of red blood cells and it's relation with vitamins A, E and C intake in 30 obese women. SUBJECTS AND METHODS: General information, anthropometric measurements, 3-day food recall, and fasting blood samples were collected from 30 obese women at the beginning of the study and after 3 months intervention. Weight loss was set at about 10% of their weight before the intervention. RESULTS: Glutathione reductase and catalase activities showed a significant increase (P < 0.01) after weight reduction, but no significant changes were seen in the superoxide dismutase and glutathione peroxidase activities. There was a positive linear correlation between daily vitamin C intake with superoxide dismutase enzyme after intervention (P = 0.004, r = 0.507). There was a negative linear correlation between vitamin E intake and glutathione peroxidase activity before intervention (P = 0.005, r = -0.5). A negative correlation was found between daily vitamin A intake and glutathione reductase enzyme before and after intervention (r = -0.385, r = -0.397, P < 0.05) respectively. No significant correlation was observed between vitamins A, C, E amounts and catalase activity. CONCLUSIONS: Ten percent weight reduction can have a significant role in increasing antioxidant enzymes activities, especially glutathione reductase, and catalase enzymes in obese women. However, it is important to take into consideration a balanced amount of certain nutrients while administering a diet with limited energy.