RESUMO
Cystic echinococcosis is a zoonotic disease caused by the metacestode of Echinococcus granulosus sensu lato. The disease is characterized by the development of cystic structures inside viscera of the intermediate host, mainly liver and lungs. These cysts are formed by three layers: germinal, laminated, and adventitial layer, the latter being the local host immune response. Metacestodes that develop protoscoleces, the infective stage to the definitive host, are termed fertile, whereas cysts that do not produce protoscoleces are termed non-fertile. Sheep usually harbor fertile cysts while cattle usually harbor non-fertile cysts. Adventitial layers with fibrotic resolution are associated to fertile cysts, whereas a granulomatous reaction is associated with non-fertile cysts. The aim of this study was to analyze cellular distribution in the adventitial layer of fertile and non-fertile E. granulosus sensu stricto cysts found in liver and lungs of cattle and sheep. A total of 418 cysts were analyzed, 203 from cattle (8 fertile and 195 non-fertile) and 215 from sheep (64 fertile and 151 non-fertile). Fertile cysts from cattle showed mixed patterns of response, with fibrotic resolution and presence of granulomatous response in direct contact with the laminated layer, while sheep fertile cysts always displayed fibrotic resolution next to the laminated layer. Cattle non-fertile cysts display a granulomatous reaction in direct contact with the laminated layer, whereas sheep non-fertile cysts display a granulomatous reaction, but in direct contact with the fibrotic resolution. This shows that cattle and sheep cystic echinococcosis cysts have distinct local immune response patterns, which are associated to metacestode fertility.
Assuntos
Doenças dos Bovinos/fisiopatologia , Cistos/veterinária , Equinococose Hepática/veterinária , Equinococose Pulmonar/veterinária , Equinococose/veterinária , Echinococcus granulosus/fisiologia , Doenças dos Ovinos/fisiopatologia , Animais , Bovinos , Doenças dos Bovinos/parasitologia , Cistos/parasitologia , Cistos/fisiopatologia , Equinococose/parasitologia , Equinococose/fisiopatologia , Equinococose Hepática/parasitologia , Equinococose Hepática/fisiopatologia , Equinococose Pulmonar/parasitologia , Equinococose Pulmonar/fisiopatologia , Ovinos , Doenças dos Ovinos/parasitologia , Carneiro DomésticoRESUMO
Os autores relatam o caso de um paciente do sexo masculino, com 55 anos de idade, branco, com diagnóstico radiológico e histopatológico pós-cirúrgico de cisto hidático pulmonar gigante. A epidemiologia, fisiopatologia e características radiológicas desta doença são discutidas
The authors report a case of a 55-year-old white male patient with radiological and postsurgical histopathological diagnosis of a giant lung hydatid cyst. The epidemiological, physiopathological and radiological findings of this disease are discussed.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Equinococose Pulmonar/cirurgia , Equinococose Pulmonar/diagnóstico , Equinococose Pulmonar/fisiopatologia , Pneumopatias Parasitárias , Pulmão , Pneumonectomia , Tomografia Computadorizada por Raios XRESUMO
Se estudió una paciente de 21 años, que nació y vive en el Distrito Federal, la cual tuvo un quiste hidatídico pulmonar con apertura mixta a bronquios y pleura. Este es el primer caso que se conoce en México con esta presentación clínica y radiológica. Clínicamente la enferma tuvo tos con expectoración "salada", fiebre, disnea y a la exploración física reveló eritema facial, broncoespasmo bilateral y derrame pleural derecho; la imagen radiológica mostró una lesión parenquimatosa con signo del "doble arco" y derame pleural. Se le realizó una broncoscopia y una punción pleural, las muestras obtenidas mediante estos procedimientos revelaron los ganchos característicos y el parásito. La paciente fue manejada con pleurotomía cerrada durante 53 días y albendazol 10 mg/kg-perso en dos ciclos de 30 días con un intervalo de descanso de 15 días entre uno y otro ciclo. Clínicamente la paciente se encuestra curada a 30 meses de seguimiento