RESUMO
OBJECTIVES: To characterize the presence of and risk factors for throat pain or irritation among male and female university teachers in private institutions within the city of São Paulo. STUDY DESIGN: This is a cross-sectional survey. METHODS: Voice self-evaluation forms prepared by the Brazilian Ministry of Labor were administered to 846 university teachers in a private institution in the city of São Paulo, Brazil. RESULTS: The prevalence of throat pain or irritation was 50.8% and was higher in the women (62.7%) than in the men (43.5%). The prevalence of throat pain or irritation was higher among professionals ≤60 years old and among those who spent most of their time teaching compared with those who spent most of their time performing other professional activities. Other factors, such as noise and sound competition, air pollution, stress and anxiety, personal habits, and lifestyle/quality of life, were related to the presence of throat pain or irritation. CONCLUSIONS: University teachers demonstrated a high prevalence of throat pain or irritation. Factors such as age ≤60 years, female gender, time-consuming professional activities, noise and sound competition in the work environment, stress and anxiety, air pollution, access to water, personal habits, and lifestyle/quality of life were related to the presence of throat pain or irritation.
Assuntos
Docentes , Doenças Profissionais/epidemiologia , Faringite/epidemiologia , Fonação , Universidades , Prega Vocal/fisiopatologia , Distúrbios da Voz/epidemiologia , Qualidade da Voz , Brasil/epidemiologia , Estudos Transversais , Feminino , Hábitos , Inquéritos Epidemiológicos , Humanos , Descrição de Cargo , Estilo de Vida , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/diagnóstico , Doenças Profissionais/fisiopatologia , Saúde Ocupacional , Faringite/diagnóstico , Faringite/fisiopatologia , Prevalência , Fatores de Risco , Autorrelato , Distúrbios da Voz/diagnóstico , Distúrbios da Voz/fisiopatologia , Local de TrabalhoRESUMO
"Streptococcus salivarius" strains, isolated from children with and without sore throat, were tested for bacteriocin production against "Streptococcus pyogenes. "S. salivarius" strains producing bacteriocin-like inhibitory substances (BLIS) against "S. pyogenes" were more frequently found in children without sore throat by the presence of BLIS-positive "S. salivarius" strains
Assuntos
Streptococcus/isolamento & purificação , Streptococcus/patogenicidade , Streptococcus pyogenes/isolamento & purificação , Streptococcus pyogenes/patogenicidade , Bacteriocinas/análise , Faringite/fisiopatologia , Técnicas e Procedimentos DiagnósticosRESUMO
OBJECTIVES: To describe the presentation, clinical course, therapeutic response, and long-term follow-up of patients with a syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA). STUDY DESIGN: Patients with PFAPA (n = 94) referred over a 10-year period completed a registry form and provided medical records. Follow-up telephone calls were made in late 1997 to determine the persistence of episodes and sequelae. RESULTS: PFAPA episodes lasted 4.8 days (95% confidence interval 4.5 to 5.1) and recurred every 28 days (confidence interval 26 to 30), with a maximal temperature of 40.5 degrees C (confidence interval 40. 4 degrees to 40.6 degrees ). Of the 83 children available for follow-up, 34 no longer had episodes. In the remainder the episodes did not differ in character but recurred less frequently over time. The affected children had no long-term sequelae. Glucocorticoids were highly effective in controlling symptoms. Tonsillectomy and cimetidine treatment were associated with remission in a small number of patients. CONCLUSIONS: PFAPA is a not uncommon cause of periodic fever in children. In some children the syndrome resolves, whereas symptoms in others persist. Long-term sequelae do not develop. The syndrome is easily diagnosed when regularly recurring episodes of fever are associated with aphthous stomatitis, pharyngitis, or cervical adenitis.
Assuntos
Febre Familiar do Mediterrâneo , Febre , Linfadenite , Faringite , Estomatite Aftosa , Idade de Início , Pré-Escolar , Febre Familiar do Mediterrâneo/diagnóstico , Febre Familiar do Mediterrâneo/fisiopatologia , Febre Familiar do Mediterrâneo/terapia , Feminino , Febre/diagnóstico , Febre/fisiopatologia , Febre/terapia , Seguimentos , Humanos , Linfadenite/diagnóstico , Linfadenite/fisiopatologia , Linfadenite/terapia , Masculino , Faringite/diagnóstico , Faringite/fisiopatologia , Faringite/terapia , Estomatite Aftosa/diagnóstico , Estomatite Aftosa/fisiopatologia , Estomatite Aftosa/terapia , SíndromeRESUMO
We report 28 patients (20 male) with a syndrome characterized by abrupt onset of fever, malaise, aphthous stomatitis, tonsillitis, pharyngitis, and cervical adenopathy (PFAPA syndrome). Episodes of fever occurred at intervals of 5.1 +/- 1.3 weeks beginning at the age of 4.2 +/- 2.7 years. Fever, malaise, tonsillitis with negative throat cultures, and cervical adenopathy were reported in all 28 patients, aphthae in 19, headache in 5, abdominal pain in 5, and arthralgia in 3. Mild hepatosplenomegaly was observed in 6 patients. Mild leukocytosis, elevation of the erythrocyte sedimentation rate, and fibrinogen were found during attacks. These episodes of illness resolved spontaneously in 4.3 +/- 1.7 days. Serum IgD was found elevated (>100 U/mL) in 12 of the 18 patients tested (140.2 +/- 62.4 U/mL). Affected children grow normally, have no associated diseases, and have no long-term sequelae. Attacks were aborted by a single dose of oral prednisone (2 mg/kg) at the beginning of the attack in all 15 patients in whom this medication was prescribed. In 9 patients the syndrome has completely resolved (beginning at the age of 2.9 +/- 1.3 and lasting 8 +/- 2.5 years). In 3 other patients complete resolution of the attacks occurred after tonsillectomy was performed. PFAPA is sporadic, and no ethnic predilection was found. Increased awareness of the clinical syndrome has resulted in more frequent diagnosis and adequate treatment.