RESUMO
Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by (1)H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.
Assuntos
Fumaratos/química , Fumaratos/síntese química , Membranas Artificiais , Adesivo Transdérmico , Administração Cutânea , Portadores de Fármacos/síntese química , Portadores de Fármacos/química , Portadores de Fármacos/farmacocinética , Sistemas de Liberação de Medicamentos/instrumentação , Fumaratos/farmacocinética , Fumaratos/farmacologia , Teste de Materiais , Micro-Ondas , Modelos Biológicos , Polímeros/síntese química , Polímeros/química , Polímeros/farmacocinética , Polímeros/farmacologia , Álcool de Polivinil/química , Álcool de Polivinil/farmacologia , Solventes/farmacologia , Resistência à Tração , Água/metabolismoRESUMO
Aliskiren, the first in a new class of orally effective direct renin inhibitors (DRIs) was recently approved for the treatment of hypertension. In this review, we discuss the history of the development of DRIs and available data regarding the effects of DRIs in the treatment of hypertension and related target organ damage.