Assuntos
Gnathostoma , Gnatostomíase , Animais , Humanos , Larva , Gnatostomíase/diagnóstico , Gnatostomíase/tratamento farmacológicoRESUMO
Abstract Gnathostomiasis is a parasitic zoonosis caused by the helminth Gnathostoma spp., acquired through the consumption of raw or undercooked contaminated aquatic animals.The disease is endemic in Southeast Asia and Central America. Two male patients, both middle-aged, presented with single itchy erythemato-edematous plaques on the anterior thorax and left flank. Both had consumed raw fish in the Amazon region. The clinical and epidemiological examinations suggested gnathostomiasis, and treatment with albendazole caused total regression of the lesions. Health teams should be familiar with the disease to provide correct diagnosis. The control strategy should be based on health education for the population.
Assuntos
Humanos , Animais , Masculino , Gnatostomíase/diagnóstico , Gnatostomíase/tratamento farmacológico , Gnathostoma , Brasil , Zoonoses , Água Doce , Pessoa de Meia-IdadeRESUMO
Gnathostomiasis is a parasitic zoonosis caused by the helminth Gnathostoma spp., acquired through the consumption of raw or undercooked contaminated aquatic animals.The disease is endemic in Southeast Asia and Central America. Two male patients, both middle-aged, presented with single itchy erythemato-edematous plaques on the anterior thorax and left flank. Both had consumed raw fish in the Amazon region. The clinical and epidemiological examinations suggested gnathostomiasis, and treatment with albendazole caused total regression of the lesions. Health teams should be familiar with the disease to provide correct diagnosis. The control strategy should be based on health education for the population.
Assuntos
Gnathostoma , Gnatostomíase , Animais , Brasil , Água Doce , Gnatostomíase/diagnóstico , Gnatostomíase/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , ZoonosesRESUMO
Human gnathostomiasis, which is endemic in Mexico, is a worldwide health concern. It is mainly caused by the consumption of raw or insufficiently cooked fish containing the advanced third-stage larvae (AL3A) of Gnathostoma species. The diagnosis of gnathostomiasis is based on epidemiological surveys and immunological diagnostic tests. When a larva is recovered, the species can be identified by molecular techniques. Polymerase chain reaction (PCR) amplification of the second internal transcription spacer (ITS-2) is useful to identify nematode species, including Gnathostoma species. This study aims to develop a duplex-PCR amplification method of the ITS-2 region to differentiate between the Gnathostoma binucleatum and G. turgidum parasites that coexist in the same endemic area, as well as to identify the Gnathostoma larvae recovered from the biopsies of two gnathostomiasis patients from Sinaloa, Mexico. The duplex PCR established based on the ITS-2 sequence showed that the length of the amplicons was 321 bp for G. binucleatum and 226 bp for G. turgidum. The amplicons from the AL3A of both patients were 321 bp. Furthermore, the length and composition of these amplicons were identical to those deposited in GenBank as G. binucleatum (accession No. JF919679), corroborating our previous morphological finding that G. binucleatum is the etiological agent for human gnathostomiasis in the endemic area of Sinaloa, Mexico.
Assuntos
DNA de Helmintos/genética , DNA Intergênico/genética , Gnathostoma/classificação , Gnatostomíase/parasitologia , Adulto , Animais , Biópsia , Doenças Endêmicas , Feminino , Humanos , Larva , México , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Pele/parasitologia , Pele/patologiaRESUMO
Gnathostomiasis is an emerging disease in non-endemic countries. This zoonotic nematode requires aquatic freshwater environments to complete its life cycle where larvae get encrusted in fishes. Typically, the infection manifests as migratory subcutaneous lesion caused by the larvae trak, which produces an eosinophilic panniculitis. Here we describe a patient who presented a migratory lesion with no response to antimicrobial therapy, a careful travel and food history together with specific laboratory tests led to the correct diagnosis. Gnathostomiasis should be suspected in patients with migratory skin lesions who have consumed raw freshwater fish during travel to endemic countries in South America or Asia.
Assuntos
Gnatostomíase/patologia , Vulvite/patologia , Vulvite/parasitologia , Adulto , Animais , Diagnóstico Diferencial , Feminino , Gnathostoma , Gnatostomíase/parasitologia , Humanos , Paniculite/parasitologia , Paniculite/patologia , Doença Relacionada a Viagens , Vulvite/diagnóstico por imagemRESUMO
Resumen La gnatostomiasis es una parasitosis emergente en países no endémicos. Este nematodo zoonótico requiere de agua dulce para su ciclo de vida, donde sus larvas se enquistan principalmente en peces. La migración subcutánea de las larvas produce habitualmente una paniculitis eosinofílica de rápido avance. Se describe un caso clínico de un paciente con una lesión migratoria, sin mejoría clínica con terapia antibacteriana. La búsqueda de factores de riesgo, sumado a la evolución y a los hallazgos de laboratorio hizo sospechar el diagnóstico. La gnatostomiasis debe ser sospechado en pacientes con lesiones de piel migratorias, que han consumido pescado crudo durante viajes a países endémicos en Sudamérica o Asia.
Gnathostomiasis is an emerging disease in non-endemic countries. This zoonotic nematode requires aquatic freshwater environments to complete its life cycle where larvae get encrusted in fishes. Typically, the infection manifests as migratory subcutaneous lesion caused by the larvae trak, which produces an eosinophilic panniculitis. Here we describe a patient who presented a migratory lesion with no response to antimicrobial therapy, a careful travel and food history together with specific laboratory tests led to the correct diagnosis. Gnathostomiasis should be suspected in patients with migratory skin lesions who have consumed raw freshwater fish during travel to endemic countries in South America or Asia.
Assuntos
Humanos , Animais , Feminino , Adulto , Vulvite/parasitologia , Vulvite/patologia , Gnatostomíase/patologia , Vulvite/diagnóstico , Paniculite/parasitologia , Paniculite/patologia , Diagnóstico Diferencial , Gnatostomíase/parasitologia , Doença Relacionada a Viagens , GnathostomaRESUMO
A 69-year-old male dentist in Caracas, Venezuela, was referred to our Cornea Clinic with a history of pain, photophobia, and blurred vision on his left eye. Routine biomicroscopic examination with a slit lamp showed a worm in the corneal stroma of his left eye. The worm was surgically removed and was identified morphologically as Gnathostoma binucleatum.
Assuntos
Gnathostoma/isolamento & purificação , Gnatostomíase/parasitologia , Larva/patogenicidade , Fotofobia/parasitologia , Idoso , Animais , Córnea/parasitologia , Córnea/cirurgia , Feminino , Água Doce/parasitologia , Gnathostoma/patogenicidade , Gnatostomíase/diagnóstico por imagem , Gnatostomíase/patologia , Gnatostomíase/cirurgia , Humanos , Masculino , Fotofobia/diagnóstico por imagem , Fotofobia/patologia , Fotofobia/cirurgia , Texas , Viagem , VenezuelaRESUMO
Gnathostomiasis is a parasitic infection caused by the third larval stage of nematodes of the genus Gnathostoma. The disease is endemic in some countries around the world. In the American continent, the majority of cases is concentrated in Mexico, Ecuador, and Peru. However, due to increasing traveling either at the intercontinental or intracontinental level, the disease is seen each time more frequently in tourists. Furthermore, countries, such as Brazil, that have never been considered endemic are reporting autochthonous cases. The disease usually presents as a deep-seated or slightly superficial migratory nodule in patients with history of eating raw fish, in the form of ceviche, sushi, or sashimi. Along with the clinical presentation, diagnostic criteria include either blood or tissue eosinophilia. In most instances, these criteria are enough for the attending physician to institute therapy. Chances of finding the parasite are low, unless the biopsy is taken from a very specific area that develops after antiparasitic treatment is started. The potential of other organ involvement with more serious consequences should always be kept in mind.
Assuntos
Gnatostomíase/patologia , Dermatopatias Parasitárias/patologia , Pele/parasitologia , Animais , Biópsia , Brasil , Dermatologistas , Parasitologia de Alimentos , Gnathostoma , Gnatostomíase/diagnóstico , Humanos , Peru , Pele/patologia , Dermatopatias Parasitárias/diagnósticoRESUMO
Abstract: Gnathostomiasis is a parasitic infection caused by the third larval stage of nematodes of the genus Gnathostoma. The disease is endemic in some countries around the world. In the American continent, the majority of cases is concentrated in Mexico, Ecuador, and Peru. However, due to increasing traveling either at the intercontinental or intracontinental level, the disease is seen each time more frequently in tourists. Furthermore, countries, such as Brazil, that have never been considered endemic are reporting autochthonous cases. The disease usually presents as a deep-seated or slightly superficial migratory nodule in patients with history of eating raw fish, in the form of ceviche, sushi, or sashimi. Along with the clinical presentation, diagnostic criteria include either blood or tissue eosinophilia. In most instances, these criteria are enough for the attending physician to institute therapy. Chances of finding the parasite are low, unless the biopsy is taken from a very specific area that develops after antiparasitic treatment is started. The potential of other organ involvement with more serious consequences should always be kept in mind.
Assuntos
Humanos , Animais , Pele/parasitologia , Dermatopatias Parasitárias/patologia , Gnatostomíase/patologia , Peru , Pele/patologia , Dermatopatias Parasitárias/diagnóstico , Biópsia , Brasil , Parasitologia de Alimentos , Gnatostomíase/diagnóstico , Dermatologistas , GnathostomaRESUMO
This case report describes the second reported case of gnathostomiasis acquired in Brazil. The French traveller returned from a sport fishing trip from Tocantins where he was repeatedly consuming raw freshwater fish marinated with lemon juice. Gnathostoma infection was diagnosed based on clinical symptoms, dietary record and by detection of specific antibodies in the blood.