RESUMO
The history of hemophilia is ancient, with descriptions dated to the 2nd century AD. The first modern narratives appeared in 1800s, when total blood transfusion was the only available treatment and life expectancy was remarkably low. Advances occurred with the use of plasma and cryoprecipitate, but only the discovered of factor concentrates revolutionized the treatment. The implantation of prophylaxis allowed hemophilic patients to prevent bleeding and the development of chronic arthropathy, although with a significant burdensome with the regular infusions. In the past 20 years, this field has witnessed major improvements, including the development of gene therapy and other pharmacological approaches.
Assuntos
Humanos , História do Século XIX , História do Século XX , História do Século XXI , Fator IX/história , Fator VIII/história , Hemofilia B/história , Hemofilia A/história , Hemofilia B/terapia , Hemofilia A/terapiaAssuntos
Hemofilia A/complicações , Hemofilia A/história , Hemofilia B/complicações , Hemofilia B/história , Hemorragia/história , Hemorragia/terapia , Medicina de Precisão/história , Criança , Hemofilia A/terapia , Hemofilia B/terapia , Hemorragia/etiologia , História do Século XX , História do Século XXI , Humanos , Medicina de Precisão/métodos , Estados UnidosRESUMO
The primary objective of this chapter is to deal with the most important bleeding disorders from a dental point of view. An understanding of the disorders discussed in this section hinges upon a basic knowledge of the various physiological processes involved in normal haemostasis (AU)