RESUMO
BACKGROUND/OBJECTIVES: Most studies about Papillon-Lefèvre syndrome (PLS) are limited to case reports and patients of the same nationality. This study aimed to determine the self-reported prevalence of signs, symptoms and treatment effectiveness in PLS patients from five Latin American countries. METHODS: An online survey was conducted among adult and paediatric patients from Mexico, Argentina, Colombia and Brazil. Data were collected using multiple-choice, open-ended and image-chooser questions on demographics, signs and symptoms, perceived treatment effectiveness and quality of life. RESULTS: Seventeen patients (10 males and 7 females) aged 4-47 years were surveyed. All had palmoplantar hyperkeratosis. Other affected sites were the feet and hand dorsum (82.35%), Achilles tendon (88.24%), forearms (58.82%), legs (29.41%) and glutes (23.53%). They frequently presented hyperhidrosis and nail pitting. Four had a history of delayed umbilical cord separation. All used topical treatments, with moderate effectiveness; half used oral retinoids, perceived as highly effective. Most reported decreased quality of life and walking difficulties. CONCLUSIONS: The study's results align with prior research on PLS, but reveal new insights, including the impact on patients' quality of life and a history of delayed umbilical cord separation. These findings warrant consideration in future research and patient care.
Assuntos
Doença de Papillon-Lefevre , Qualidade de Vida , Autorrelato , Humanos , Masculino , Feminino , Adulto , Estudos Transversais , Adolescente , Criança , Pessoa de Meia-Idade , Adulto Jovem , Pré-Escolar , Brasil , Colômbia , Resultado do Tratamento , México , Argentina , Retinoides/uso terapêutico , Hiperidrose/terapia , Doenças da Unha/terapiaRESUMO
PURPOSE: To evaluate, via a systematic review, the effectiveness of radiofrequency (RF) for treatment of primary hyperhidrosis (PH). METHODS: Experimental or observational studies were included where RF treatment (ablation or microneedling) was performed, comparing the periods before and after treatment. RESULTS: Nine studies were considered eligible and included for analysis. In seven of nine studies, patients were subjected to RF only, and in two of nine studies RF was compared to video-assisted thoracoscopic sympathectomy (VATS). There was a reduction in the severity of PH in microneedling (three studies, mean difference -1.24, 95% CI -1.44 to -1.03). In a study that performed sympathetic RF ablation there was a greater reduction in PH severity compared to studies that performed microneedling (-2.42, 95% CI -2.55 to -2.29). There was improvement in the quality of life (QoL) after sympathetic RF ablation (two studies, mean difference -15.92, 95% CI -17.61 to -14.24). Regarding the microneedling procedure, there was a lower improvement in QoL, (two studies, -9.0, 95% CI -9.15 to -8.85). One study comparing sympathetic RF ablation with VATS applied the QoL questionnaire, and the VATS showed superior results. One of the two studies comparing compensatory sweating in RF ablation with VATS showed that compensatory hyperhidrosis was higher in VATS; however, the other study did not observe this difference. One study compared the recurrence of symptoms between VATS and RF ablation; symptom recurrence was shown to be higher in RF. CONCLUSIONS: RF is effective for PH treatment, with superior results obtained with sympathetic ablation compared to microneedling.
Assuntos
Hiperidrose/diagnóstico , Hiperidrose/terapia , Terapia por Radiofrequência/métodos , Humanos , Hiperidrose/fisiopatologia , Estudos Observacionais como Assunto/métodos , Satisfação do Paciente , Terapia por Radiofrequência/tendências , Simpatectomia/métodos , Simpatectomia/tendências , Toracoscopia/métodos , Toracoscopia/tendências , Resultado do TratamentoRESUMO
Abstract Hyperhidrosis (HH) is characterized by sweating exceeding the amount necessary to meet the thermal regulation and physiological needs of the body. Approximately 9.41% of individuals with HH have craniofacial hyperhidrosis (FH). The present study aims to review the most current data in the literature regarding craniofacial hyperhidrosis, including pathophysiology, diagnosis and clinical presentation, treatment options (clinical and surgical), and outcomes. VATS (videothoracoscopy sympathectomy) is considered the gold standard for definitive treatment of axillary or palmar hyperhidrosis. Recently, several studies have shown the usefulness of clinical treatment with oxybutynin hydrochloride, leading to clinical improvement of HH in more than 70% of users. Both clinical and surgical treatment of craniofacial hyperhidrosis have good results. However, surgical treatment of FH is associated with more complications. Clinical treatment with oxybutynin hydrochloride yields good results and can be the first therapeutic option. When the patient is not satisfied with this treatment and has good clinical conditions, surgical treatment can be used safely.
Resumo A hiperidrose (HH) é caracterizada por transpiração além da quantidade necessária para manter a regulação térmica e as necessidades fisiológicas do corpo. Aproximadamente 9,41% dos indivíduos com HH apresentam hiperidrose craniofacial (FH). Este estudo tem como objetivo revisar os dados mais atuais da literatura sobre FH, incluindo fisiopatologia, diagnóstico e apresentação clínica, opções de tratamento (clínico e cirúrgico) e desfechos. A simpatectomia por videotoracoscopia (VATS) é considerada o padrão-ouro para o tratamento definitivo da hiperidrose axilar ou palmar. Recentemente, vários estudos demonstraram a utilidade do tratamento clínico com cloridrato de oxibutinina, que leva à melhora clínica da HH em mais de 70% dos pacientes. O tratamento clínico e o cirúrgico apresentam bons resultados no tratamento da FH. No entanto, o tratamento cirúrgico da FH apresenta mais complicações. O tratamento clínico com cloridrato de oxibutinina fornece bons resultados e pode ser a primeira opção terapêutica. Quando o paciente não está satisfeito com esse tratamento e mostra boas condições clínicas, o tratamento cirúrgico pode ser usado com segurança.
Assuntos
Humanos , Simpatectomia , Antagonistas Colinérgicos/uso terapêutico , Hiperidrose/terapia , Sudorese , Toxinas Botulínicas/uso terapêutico , Cabeça , Hiperidrose/diagnóstico , Hiperidrose/fisiopatologiaRESUMO
Resumen Introducción: La hiperhidrosis palmar primaria es un problema médico frecuente. Minimizar la invasión, simplificar y estandarizar la técnica supone mejores resultados. Objetivo: Evaluar eficacia y seguridad con la aplicación de nuestra técnica simplificada y estandarizada, a través de su impacto en los resultados trans y postoperatorio para la hiperhidrosis palmar primaria (HPP). Materiales y Método: Se realiza estudio observacional que evalúa los resultados obtenidos con la aplicación de nuestra técnica estandarizada para el tratamiento de HPP. El universo está constituido por 359 pacientes intervenidos entre 2007 y 2011. El control hasta los 5 años fue posible en 298, los que constituyeron la muestra definitiva. Resultados: Se analizaron 298 pacientes (596 procedimientos). En el transoperatorio solo 3 pacientes (1%) presentaron alguna complicación. El manejo del dolor torácico fue la mayor dificultad inmediata a la cirugía, con 61,7% de dolor moderado y 15,2% severo. Último control a 5 años con curación en el 99,7% y una recidiva. Los índices de satisfacción se muestran en rango excelente según encuestas validadas. Manejo ambulatorio en 99%. Discusión: Aplicar intubación endotraqueal simple permite extrapolar ventajas ya conocidas de esta técnica y menos complicaciones respiratorias, suspensiones, uso de recursos costosos o personal muy calificado. La combinación de simplificar aspectos quirúrgicos y anestésicos permitieron estandarizar y simplificar nuestra técnica y con ello: no necesitar drenajes pleurales, menos dolor, recuperación casi inmediata de la fisiología respiratoria y alta precoz. Conclusión: Combinar el empleo de tubo endotraqueal simple y oxigenación apneíca con minimizar la invasión quirúrgica: puerto único, sin drenaje pleural y manejo ambulatorio constituyen una práctica segura para la simpatectomía torácica endoscópica, con mejores resultados postoperatorios, una vez logrado en entrenamiento necesario.
Introduction: Primary palmar hyperhidrosis is a frequent medical problem. Minimizing invasion, simplifying and standardizing technique means better results. Aim: To evaluate efficacy and safety with the application of our simplified and standardized technique, through its impact on trans and post-operative outcomes for primary palmar hyperhidrosis (PPH). Minimizing approach, simplifying and standardizing the technique should lead to better outcomes. Materials and Method: An observational study is carried out to evaluate the outcomes obtained with the application of our standardized technique for the treatment of PPH. The universe constituted by 359 patients treated between 2007 and 2011. Control up to 5 years was possible in 298, which constituted the definitive sample. Results: 298 patients (596 procedures) were analyzed. In the transoperative only 3 patients (1%) report minor complication. Thoracic pain management was the greatest difficulty immediate to surgery, with 61.7% moderate pain and 15.2% severe. Satisfaction indexes in excellent range according to validated surveys. Outpatient management in 99%. Discussion: Simple intubation avoids respiratory complications, suspensions, use of expensive resources or highly qualified personnel. Early pain relief, non-uses of pleural tubes or antibiotics allows rapid recovery and early discharge due to simplification and standardization of the technique. Conclusion: The use of simple endotraqueal tube and oxygenation in apnea, single port, without pleural drainage or antibiotics and ambulatory is a safe practice for endoscopic thoracic sympathectomy, once achieved in necessary training.
Assuntos
Humanos , Masculino , Feminino , Cuidados Pós-Operatórios/métodos , Padrões de Referência , Procedimentos Cirúrgicos Operatórios/métodos , Mãos/cirurgia , Hiperidrose/cirurgia , Dor Pós-Operatória/prevenção & controle , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Hiperidrose/terapiaRESUMO
BACKGROUND: Hyperhidrosis is a pathological condition defined by excessive sweating beyond thermoregulatory physiological needs, which can cause substantial psychological impact and impairment of daily activities. Studies regarding its prevalence, however, are scarce and vary widely in their findings. The population of medical students is a particularly interesting subset for its recurring demand of physical contact during patient examination or procedures, and the potential for professional adversity. We aimed at furthering the comprehension of this disease prevalence and characteristics among medical students. METHODS: Questionnaires inquiring about the presence and characteristics of Primary Hyperhidrosis (PH) were applied through either written or digital means to all eligible medical students enrolled in three Medical Schools in the State of Rio de Janeiro who agreed to take part in the study. Demographic data regarding gender, ethnicity, current age, weight and height was collected in addition to clinical data (sweat site, age of onset, familial history, severity and previous treatments). Severity was evaluated through the Hyperhidrosis Disease Severity Scale (HDSS) and a symptoms survey. FINDINGS: Our response rate was roughly 1/3 of all eligible students (900/2700). PH prevalence was 20.56% (185/900). It was similar between men and women (23.08% and 19.41%, respectively) and strongly associated with family history of the disease (Prevalence Ratio of 4.27). Regarding ethnicity, of the total sample 73.78% (664/900) self-declared white, among which 19.28% (128/664) had PH. Mixed-race and other ethnicities encompassed 26.22% (236/900) of the sample, among which 24.15% (57/236) had PH. Most positive subjects (64.32%) presented associated forms of PH. Overall involvement of each site (both associated and isolated) was: 63.78% axillary, 50.81% palmar, 43.24% plantar, 20.54% craniofacial, 18.38% facial flushing and 2.16% gustatory sweating. Mean current age was 23.11(±4.04) years for PH patients, and age of onset was ≤18 years in 93.94% of cases. Regarding body mass index (BMI), 71.09% of PH patients had BMI<25kg/m2 and only 4.69% presented BMI≥30kg/m2, none ≥35kg/m2. Some degree of life quality impairment was reported by 89.20% of PH patients, and 23.89% had HDSS 3 or 4 (moderate to severe). CONCLUSIONS: PH prevalence among Rio de Janeiro medical students was 20.56%, similar between men and women, predominating associated presentations, axillary, palmar and plantar sites, strong familial history, age of onset before 18 years, and some degree of life impairment.
Assuntos
Hiperidrose/epidemiologia , Estudantes de Medicina , Brasil/epidemiologia , Gerenciamento Clínico , Feminino , Humanos , Hiperidrose/diagnóstico , Hiperidrose/terapia , Masculino , Prevalência , Vigilância em Saúde Pública , Índice de Gravidade de Doença , Avaliação de SintomasRESUMO
On July 25, 2017, we conducted an extensive database tracking to identify all studies published from January 1990 to July 2017. Screening updates were performed until December 2017. RESULTS: There were no deaths, and the resolution of symptoms of primary plantar hyperhidrosis (PPH) occurred in 92% of patients after mechanical sympathectomy. A total of 177 patients (44%) were reported to have mild to severe compensatory sweating after a mean 6 months follow-up. The preservation of L2 did not interfere with the primary outcome, and it is possible to perform lumbar sympathectomy in men with L2 preservation, achieving satisfactory cure results of PPH, minimizing the risk of sexual dysfunction. There were no deaths, and the resolution of symptoms of PPH occurred in 10% of patients after chemical sympathicolysis after a mean 6 months follow-up. A total of 13 patients (12.5%) were reported to have mild to severe compensatory sweating using the same technique. CONCLUSION: The mechanical lumbar sympathectomy is effective and safe and improves quality of life, evaluated by the high symptom resolution of PPH and low rate of complications. The chemical sympathicolysis in the immediate postoperative period presented satisfactory results; however, it was shown to be significantly less effective than the mechanical approach in a follow-up of at least 6 months.
Assuntos
Hiperidrose/terapia , Plexo Lombossacral/cirurgia , Complicações Pós-Operatórias/epidemiologia , Soluções Esclerosantes/administração & dosagem , Simpatectomia/métodos , Terapia Combinada/efeitos adversos , Terapia Combinada/métodos , Feminino , Pé , Humanos , Hiperidrose/diagnóstico , Hiperidrose/psicologia , Plexo Lombossacral/efeitos dos fármacos , Masculino , Tratamentos com Preservação do Órgão/efeitos adversos , Tratamentos com Preservação do Órgão/métodos , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/etiologia , Qualidade de Vida , Soluções Esclerosantes/efeitos adversos , Índice de Gravidade de Doença , Fatores Sexuais , Disfunções Sexuais Fisiológicas/etiologia , Disfunções Sexuais Fisiológicas/prevenção & controle , Simpatectomia/efeitos adversos , Resultado do TratamentoRESUMO
La hiperhidrosis es un aumento patológico de la sudoración, que puede asociarse a patologías médicas y fármacos, afectando en forma significativa la calidad de vida. La hiperhidrosis focal primaria es una patología común, cuyo manejo es un desafío. Están disponibles múltiples terapias para el tratamiento de hiperhidrosis, incluyendo productos tópicos, iontoforesis, toxina botulínica, fármacos sistémicos, cirugía y nuevos equipos para destrucción selectiva de las glándulas sudoríparas. El propósito de este artículo es revisar la literatura, enfocándose en las terapias no quirúrgicas y opciones de tratamiento emergentes.
Hyperhidrosis is a pathological excessive sweating. It can be associated with medical conditions or drugs and affect significantly the quality of life. Primary focal hyperhidrosis is a common disorder for which treatment is often a therapeutic challenge. Multiple therapies are available for the treatment of hyperhidrosis, including topical products, iontophoresis, botulinum toxin, systemic medications, surgery and new devices aimed at the destruction of ecrine glands. The purpose of this article is to review the literature, with a focus on non-surgical therapies and emerging treatment options.
Assuntos
Humanos , Hiperidrose/terapia , Índice de Gravidade de Doença , Iontoforese , Compostos de Alumínio/uso terapêutico , Toxinas Botulínicas Tipo A/uso terapêutico , Inibidores da Liberação da Acetilcolina/uso terapêutico , Hiperidrose/diagnósticoRESUMO
Introducción: la simpaticotomía videotoracoscópica es actualmente la técnica quirúrgica de elección en el tratamiento de la hiperhidrosis esencial o primaria. Sus ventajas relacionadas con su sencillez, menor posibilidades de complicaciones transoperatorias, un tiempo quirúrgico notablemente más corto y consecuentemente menor exposición a los agentes anestésicos, mejor relación riesgo/beneficio, mejor recuperación y la disminución de los efectos secundarios como el sudor compensatorio y el alto nivel de satisfacción de los pacientes, justifican su realización. Objetivo: analizar los resultados de la generalización de la simpaticotomía T3-T4 en el tratamiento de la hiperhidrosis palmar. Método: estudio de corte transversal, observacional y descriptivo de los pacientes intervenidos por videotoracoscopia, en el Centro Nacional de Cirugía de Mínimo Acceso con el diagnóstico de hiperhidrosis primaria palmar; a los cuales se les realizó simpaticotomía videotoracoscópica desde enero de 2011 hasta diciembre del 2015. En la evaluación de los pacientes se tienen en cuenta las variables aceptadas internacionalmente: curación, efectos secundarios, complicaciones y la mejoría psíquica dada por el nivel de satisfacción de los pacientes. Resultados: se logró un 97,69 por ciento de curación de la enfermedad. La sudoración compensatoria se presentó en 48,1 por ciento de los pacientes y el nivel de satisfacción fue de 97 por ciento, logrando una mejoría evidente del estado psicológico de los mismos. Conclusiones: la simpaticotomía videotoracoscópica T3-T4 es efectiva en el tratamiento de los pacientes afectos de hiperhidrosis palmar(AU)
Introduction: Videothoracoscopic sympathicotomy is currently the surgical technique of choice in the treatment of primary or essential hyperhidrosis. Its advantages related to its simplicity, fewer possibilities of transoperative complications, remarkably shorter surgical time and consequently less exposure to anesthetic agents, better risk / benefit ratio, better recovery, limited side effects such as compensatory sweat and high level of patient satisfaction support the performance of this procedure. Objective: To analyze the results of the generalization of the T3-T4 sympathicotomy in the treatment of palmar hyperhidrosis. Method: A cross-sectional, observational and descriptive study of patients with diagnosis of palmar primary hyperhidrosis, who underwent videothoracoscopic sympathicotomy at the National Center for Minimal Access Surgery from January 2011 to December 2015. The patient assessment took into account internationally accepted variables such as healing, side effects, complications and psychic improvement according to the level of satisfaction of the patients. Results: Recovery from disease reached 97.69 percent, compensatory sweating occurred in 48.1 percent of patients and the level of satisfaction was 97 percent, thus achieving clear improvement of the psychological state of patients.. Conclusions: Videothoracoscopic sympathicotomy T3-T4 is effective in the treatment of patients with palmar hyperhidrosis(AU)
Assuntos
Humanos , Hiperidrose/cirurgia , Hiperidrose/terapia , Simpatectomia/métodos , Cirurgia Torácica Vídeoassistida/efeitos adversos , Estudos Transversais , Epidemiologia Descritiva , Estudo ObservacionalRESUMO
Abstract Palmar hyperhidrosis affects up to 3% of the population and inflict significant impact on quality of life. It is characterized by chronic excessive sweating, not related to the necessity of heat loss. It evolves from a localized hyperactivity of the sympathetic autonomic system and can be triggered by stressful events. In this study, the authors discuss clinical findings, pathophysiological, diagnostic and therapeutic issues (clinical and surgical) related to palmar hyperhidrosis.
Assuntos
Humanos , Hiperidrose , Qualidade de Vida , Glândulas Sudoríparas/fisiopatologia , Simpatectomia/métodos , Diagnóstico Diferencial , Hiperidrose/diagnóstico , Hiperidrose/fisiopatologia , Hiperidrose/terapia , Ilustração MédicaRESUMO
Palmar hyperhidrosis affects up to 3% of the population and inflict significant impact on quality of life. It is characterized by chronic excessive sweating, not related to the necessity of heat loss. It evolves from a localized hyperactivity of the sympathetic autonomic system and can be triggered by stressful events. In this study, the authors discuss clinical findings, pathophysiological, diagnostic and therapeutic issues (clinical and surgical) related to palmar hyperhidrosis.