RESUMO
BACKGROUND: Follicular lipidosis is a rare disease, having only been reported in six Rottweiler dogs. The diagnosis of follicular lipidosis is confirmed by histopathological examination of the affected skin. OBJECTIVE: To report a case of follicular lipidosis in a dachshund dog. ANIMALS: A 13-month-old female dachshund dog, with hypotrichosis on the head and cervical region from 10 months of age. METHODS: Histological examination of skin biopsy specimens. RESULTS: Histological examination revealed basket weave orthokeratosis, ballooning of matrix cells and external root sheath keratinocytes. CLINICAL IMPORTANCE: This case report highlights the importance of including follicular lipidosis among the differential diagnoses of noninflammatory and nonhormonal cutaneous lesions in dachshund presented with hair loss.
Assuntos
Doenças do Cão/diagnóstico , Lipidoses/veterinária , Dermatopatias/veterinária , Animais , Diagnóstico Diferencial , Doenças do Cão/patologia , Cães , Feminino , Hipotricose/diagnóstico , Hipotricose/patologia , Hipotricose/veterinária , Lipidoses/diagnóstico , Lipidoses/patologia , Pele/patologia , Dermatopatias/diagnóstico , Dermatopatias/patologiaRESUMO
Background: Sebaceous adenitis is an inflammatory, dyskeratotic, and chronic disorder, characterized by the degeneration and post-inflammatory atrophy of sebaceous gland, which rarely affects cats. The objective of this paper is to report a case of sebaceous adenitis in a cat, located in the region of Curitiba, Paraná, Brazil. Case: A 12-year-old female cat, crossbreed, with hypotrichosis, alopecia and moderate to intense itching in the dorsal thorax region, limbs and face, which were evolving during a month. Dermatological exams were done, as well as trichogram, fungal culture, sticky-tape test, skin scraping, and parasitological assessments of cerumen, and all of them were normal. Histopathological examination revealed hair follicles at all stages of development, some showing hyperkeratosis with cystic dilation and complete absence of sebaceous glands. In periadnexal region, it showed mild inflammatory infiltrate composed by lymphocytes, histiocytes and neutrophils, which legitimated a definitive diagnosis of sebaceous adenitis. The treatment was made using emollient shampoo, ciclosporin and emollient product based on fatty acids and ceramides, and after one month, the lesions, erythema and pruritus regressed. Due to the clinical improvement, it was possible to keep the animal with ciclosporin (5.0 mg/kg, p.o, every two days) and Allerderm spot-on (once weekly), obtaining pos...
Assuntos
Feminino , Animais , Gatos , Alopecia/veterinária , Glândulas Sebáceas/patologia , Hipotricose/veterinária , Linfadenite/veterinária , Ciclosporina/uso terapêutico , Dermatite Seborreica/veterináriaRESUMO
Background: Sebaceous adenitis is an inflammatory, dyskeratotic, and chronic disorder, characterized by the degeneration and post-inflammatory atrophy of sebaceous gland, which rarely affects cats. The objective of this paper is to report a case of sebaceous adenitis in a cat, located in the region of Curitiba, Paraná, Brazil. Case: A 12-year-old female cat, crossbreed, with hypotrichosis, alopecia and moderate to intense itching in the dorsal thorax region, limbs and face, which were evolving during a month. Dermatological exams were done, as well as trichogram, fungal culture, sticky-tape test, skin scraping, and parasitological assessments of cerumen, and all of them were normal. Histopathological examination revealed hair follicles at all stages of development, some showing hyperkeratosis with cystic dilation and complete absence of sebaceous glands. In periadnexal region, it showed mild inflammatory infiltrate composed by lymphocytes, histiocytes and neutrophils, which legitimated a definitive diagnosis of sebaceous adenitis. The treatment was made using emollient shampoo, ciclosporin and emollient product based on fatty acids and ceramides, and after one month, the lesions, erythema and pruritus regressed. Due to the clinical improvement, it was possible to keep the animal with ciclosporin (5.0 mg/kg, p.o, every two days) and Allerderm spot-on (once weekly), obtaining pos...(AU)
Assuntos
Animais , Feminino , Gatos , Linfadenite/veterinária , Hipotricose/veterinária , Alopecia/veterinária , Glândulas Sebáceas/patologia , Dermatite Seborreica/veterinária , Ciclosporina/uso terapêuticoRESUMO
Congenital hypotrichosis in mammalian species consists of partial or complete absence of hair at birth. The hairless gene is often responsible for this disorder in men, mice and rats. Recent experimental data on Valle del Belice sheep reared in Sicily for milk production, support the genetic control of the ovine hypotrichosis as a Mendelian recessive trait. The ovine hairless gene was chosen as the candidate gene involved in this disorder. Blood samples were collected from Valle del Belice sheep with the normal and hypotrichotic phenotypes. Almost the entire hairless gene was successfully amplified using the long PCR technique. Unrelated sheep with differing phenotypes were randomly chosen for sequencing the amplified products. Different mutations related to the hypotrichotic phenotype were found in exon 3. In fact, sequencing revealed an A/T transversion at position 739, a G/A transition at position 823, and a C/T transition at position 1312. From these nucleotide exchanges, three substitutions of the processed mature protein were deduced at the amino acid positions 247 (Thr/Ser), 275 (Ala/Thr), and 438 (Gln/Stop). A PCR-SSCP based test was developed in order to detect the last mutation, which is responsible for the hypotrichotic phenotype.