RESUMO
PURPOSE: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. METHODS: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. RESULTS: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). CONCLUSION: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.
Assuntos
Envelhecimento , Antibacterianos/uso terapêutico , Infecções por Bacteroides/complicações , Peritonite/tratamento farmacológico , Animais , Modelos Animais de Doenças , Fezes , Masculino , Peritonite/microbiologia , Ratos , Ratos Wistar , Sepse/tratamento farmacológicoRESUMO
Abstract Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.
Assuntos
Animais , Masculino , Ratos , Peritonite/tratamento farmacológico , Infecções por Bacteroides/complicações , Envelhecimento , Antibacterianos/uso terapêutico , Peritonite/microbiologia , Ratos Wistar , Sepse/tratamento farmacológico , Modelos Animais de Doenças , FezesRESUMO
BACKGROUND: Pylephlebitis or septic thrombophlebitis of the portal venous system is a rare but serious complication of intra-abdominal infections which drain into the portal venous system. Its diagnosis is based on clinical suspicion and imaging tests, mainly a computed tomography scan, given the lack of specificity of the signs and symptoms. Spread of septic emboli is the major cause of morbidity and mortality. The aim of the study was to analyse patients diagnosed in our hospital. MATERIAL AND METHODS: Retrospective descriptive study of patients diagnosed with pylephlebitis in our hospital. CLINICAL CASES: Four patients were included, 3 men and one woman. In 3 cases it was acute cholecystitis that led to the diagnosis of pylephlebitis at the same time as the intra-abdominal infection. Emergency surgery was performed in one case, whilst the other 2 were treated conservatively. Blood cultures were performed in all cases, and empirical antibiotic treatment was used. In the only case of acute appendicitis, diagnosis of pylephlebitis was achieved during the study of postoperative fever, with empirical antibiotic treatment also being started. The haematologist was requested to start the required anticoagulation therapy in all cases. CONCLUSIONS: Pylephlebitis is a rare complication of intra-abdominal infections that may make lead to a worse outcome. A high level of suspicion is required as well as imaging tests to make an early diagnosis and appropriate treatment.
Assuntos
Apendicite/complicações , Infecções por Bacteroides/complicações , Colecistite/complicações , Embolia/etiologia , Infecções por Bactérias Gram-Positivas/complicações , Infecções por Klebsiella/complicações , Veia Porta , Tromboflebite/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Anticoagulantes/uso terapêutico , Apendicectomia , Bacteriemia/etiologia , Infecções por Bacteroides/tratamento farmacológico , Infecções por Bacteroides/cirurgia , Colecistectomia , Colecistite/cirurgia , Coinfecção , Terapia Combinada , Emergências , Enterococcus faecium/isolamento & purificação , Feminino , Infecções por Bactérias Gram-Positivas/tratamento farmacológico , Infecções por Bactérias Gram-Positivas/cirurgia , Humanos , Infecções por Klebsiella/tratamento farmacológico , Infecções por Klebsiella/cirurgia , Klebsiella oxytoca/isolamento & purificação , Klebsiella pneumoniae/isolamento & purificação , Fígado/irrigação sanguínea , Fígado/patologia , Masculino , Pessoa de Meia-Idade , Veia Porta/diagnóstico por imagem , Veia Porta/microbiologia , Estudos Retrospectivos , Tromboflebite/diagnóstico por imagem , Tromboflebite/tratamento farmacológico , Tromboflebite/microbiologia , Tomografia Computadorizada por Raios XAssuntos
Apendicite/complicações , Ascaríase/complicações , Ascaris lumbricoides/isolamento & purificação , Infecções por Bacteroides/complicações , Emigrantes e Imigrantes , Infecções por Escherichia coli/complicações , Infecções por HIV/complicações , Enteropatias Parasitárias/complicações , Abscesso Abdominal/tratamento farmacológico , Abscesso Abdominal/etiologia , Abscesso Abdominal/cirurgia , Albendazol/uso terapêutico , Animais , Anti-Helmínticos/uso terapêutico , Fármacos Anti-HIV/uso terapêutico , Apendicectomia , Apendicite/tratamento farmacológico , Apendicite/cirurgia , Ascaríase/diagnóstico , Ascaríase/tratamento farmacológico , Infecções por Bacteroides/tratamento farmacológico , Infecções por Bacteroides/cirurgia , Bacteroides fragilis/isolamento & purificação , Terapia Combinada , Infecções por Escherichia coli/tratamento farmacológico , Infecções por Escherichia coli/cirurgia , Feminino , Infecções por HIV/tratamento farmacológico , Humanos , Hospedeiro Imunocomprometido , Enteropatias Parasitárias/diagnóstico , Enteropatias Parasitárias/tratamento farmacológico , Jejuno/parasitologia , Paraguai/etnologia , Ácido Penicilânico/análogos & derivados , Ácido Penicilânico/uso terapêutico , Peritonite/tratamento farmacológico , Peritonite/etiologia , Peritonite/cirurgia , Piperacilina/uso terapêutico , Combinação Piperacilina e Tazobactam , Adulto JovemRESUMO
The authors present a case of a patient with sickle-ß thalassaemia (Sß(0) Thal) who had bilateral psoas abscesses on a background of splenectomy in early childhood. The patient also turned out to have vertebral osteomyelitis and hydronephrosis on the side of the larger abscess. The only organism recovered from the patient was a Bacteroides species. The patient was managed with percutaneous drainage and intravenous antibiotics and made a full recovery.
Assuntos
Anemia Falciforme/complicações , Infecções por Bacteroides/complicações , Vértebras Lombares , Osteomielite/complicações , Abscesso do Psoas/complicações , Doenças da Coluna Vertebral/complicações , Adulto , Bacteroides , Humanos , Hidronefrose/complicações , Hidronefrose/microbiologia , Vértebras Lombares/microbiologia , Masculino , Abscesso do Psoas/microbiologiaRESUMO
A sequence of research on "Cara inchada", a periodontal disease of young cattle (CI), involving heavy losses in Brazil, is described and results of laboratory investigations and field experiments are reported. A suspicion of being a primary nutritional disease of the skeleton could not be confirmed. In the other hand, bacteria, especially of the genus Bacteroides, were isolated from the periodontal CI-lesions. These bacteria possess enough pathogenic potential, through the production of enzymes and endotoxins, to cause primary destruction of the periodontal tissues. The lesions of the upper jaw, and also of the mandibula, of the diseased animals were diagnosed as a purulent periodontitis and a secondary ossifying alveolar periostitis. As CI occurs enzootically on new, cultivated pastures in cleared forest and savanna areas, and as the incidence of the disease declines with the years of pasture use, in order to disappear again, it can be postulated that a determining factor exists in the soil and consequently in the pasture, the disturbance of the equilibrium of the microflora in the formerly virgin soil possibly causes a modification of the flora of the rumen and the oral cavity, so that bacteria, as Bacteroides spp., present in the subgingival space, could dominate and become pathogenic. The frequent diarrhoea observed in calves affected by CI could be a consequence of the modification of the microflora in the digestive tract. Accordingly, CI could be considered as an infectious periodontitis of calves due to altered ecological soil conditions.
Assuntos
Infecções por Bacteroides/veterinária , Doenças dos Bovinos/etiologia , Distúrbios Nutricionais/veterinária , Doenças Periodontais/veterinária , Animais , Infecções por Bacteroides/complicações , Brasil , Bovinos , Distúrbios Nutricionais/complicações , Doenças Periodontais/etiologiaRESUMO
A 50 year old woman while undergoing severe treatment for rheumatoid arthritis, developed anaerobic meningitis. The cerebrospinal fluid (CSF) sample was transported and cultivated aerobically and anaerobically. After 48 h at 37 degrees C the anaerobically incubated plate, the enriched fluid thioglycollate medium and the anaerobic culture medium yielded luxuriant growth of an anaerobic Gram negative bacillum. The biochemical and antimicrobial susceptibility patterns were consistent with those for Bacteroides distasonis. Most of the strains of the 5 species included in the Bacteroides fragilis group (B. fragilis, B. vulgatus, B. ovatus, B. thetaiotaomicron and B. distasonis) are resistant to penicillins, cephalosporins of first generation and aminoglycosides. Anaerobic polyresistant flora from an intraabdominal focus (chronic cholecystitis) might have been selected by treatment with gentamicin and cephalotin, and proliferated into meningeal dissemination. It is important that CSF from immunocompromised patients with acute or chronic pulmonary, intraabdominal or cranium-facial infectious processes be transported and cultured in aerobic and anaerobic conditions. These patients must be treated with an initial therapeutic scheme that includes an effective antibiotic for the anaerobic microorganism that may be involved.
Assuntos
Infecções por Bacteroides/complicações , Meningite/etiologia , Bacteroides/efeitos dos fármacos , Bacteroides/isolamento & purificação , Infecções por Bacteroides/líquido cefalorraquidiano , Resistência Microbiana a Medicamentos , Feminino , Humanos , Meningite/líquido cefalorraquidiano , Testes de Sensibilidade Microbiana , Pessoa de Meia-IdadeRESUMO
Se present ael caso de una paciente de 50 años que durante la internación por un severo cuadro de artritis reumatoidea, desarrolló una bacteriemia por Bacteroides distasonis a partir de una colecistitis no reconocida y cuya expresión final fue una meningitis. La evolución de la paciente no fue favorable por no haber recibido la terapia antibiótica adecuada en forma temprana. El diagnóstico etiológico fue realizado a través del estudio microbiológico del líquido cefalorraquídeo transportado y cultivado en aero y anaerobiosis. Este procedimiento es importante en aquellos pacientes que presentan procesos infecciosos agudos o crónicos pulmonares, intraabdominales o craneofaciales y que además son inmunocomprometidos. En tales casos debe incorporarse al esquema terapéutico inicial un antibiótico efectivo en el tratamiento de los gérmenes anaerobios que pudieran estar involucrados
Assuntos
Humanos , Pessoa de Meia-Idade , Feminino , Infecções por Bacteroides/complicações , Meningite/etiologia , Bacteroides/efeitos dos fármacos , Bacteroides/isolamento & purificação , Resistência Microbiana a Medicamentos , Líquido Cefalorraquidiano/microbiologia , Meningite/líquido cefalorraquidiano , Testes de Sensibilidade MicrobianaRESUMO
Se present ael caso de una paciente de 50 años que durante la internación por un severo cuadro de artritis reumatoidea, desarrolló una bacteriemia por Bacteroides distasonis a partir de una colecistitis no reconocida y cuya expresión final fue una meningitis. La evolución de la paciente no fue favorable por no haber recibido la terapia antibiótica adecuada en forma temprana. El diagnóstico etiológico fue realizado a través del estudio microbiológico del líquido cefalorraquídeo transportado y cultivado en aero y anaerobiosis. Este procedimiento es importante en aquellos pacientes que presentan procesos infecciosos agudos o crónicos pulmonares, intraabdominales o craneofaciales y que además son inmunocomprometidos. En tales casos debe incorporarse al esquema terapéutico inicial un antibiótico efectivo en el tratamiento de los gérmenes anaerobios que pudieran estar involucrados (AU)