RESUMO
The purpose of this study was to identify the possible effect of enteroviruses on placental tissue. Seventy-eight pregnant women were studied throughout their pregnancy: enteroviral infection was detected by faecal viral isolation and seric neutralization of previously identified virus in cell culture. In 19 cases of confirmed maternal infection, placentae were examined grossly, by optical microscopy, immunohistochemical and electron microscopic methods. Ten term placentae from women included in the study, with no clinical, serological or virological evidence of enteroviral infection, were used as control, and examined by gross and optical microscopy. In 17 specimens (echovirus-coxsackievirus) an haematogenous placentitis was suspected on the basis of gross observation. Microscopic lesions were similar to those found in other viral infections, with specific features. The nature of the inflammatory reaction pointed to the presence of an acute type of haematogenous placentitis, not present in placentae of the control group. The authors (AA) comment on the results and present the hypotheses about the available data: (1) maternal enteroviremia and faecal virus shedding without placental invasion, placentary damage being an unspecific consequence of infection; (2) direct virus-induced injury is not the only possible cause for the lesions: (3) placental enteroviral infection occurred with placental pathology but the virus did not cross the organ as the newborn had no signs of infection.
Assuntos
Infecções por Enterovirus/complicações , Doenças Placentárias/complicações , Complicações Infecciosas na Gravidez/microbiologia , Infecções por Coxsackievirus/complicações , Infecções por Coxsackievirus/microbiologia , Infecções por Coxsackievirus/patologia , Infecções por Echovirus/complicações , Infecções por Echovirus/microbiologia , Infecções por Echovirus/patologia , Infecções por Enterovirus/microbiologia , Infecções por Enterovirus/patologia , Feminino , Humanos , Microscopia Eletrônica , Doenças Placentárias/microbiologia , Doenças Placentárias/patologia , Gravidez , Complicações Infecciosas na Gravidez/patologiaAssuntos
Agamaglobulinemia/patologia , Edema/patologia , Infecções por Adenovirus Humanos/patologia , Agamaglobulinemia/complicações , Criança , Infecções por Echovirus/complicações , Infecções por Echovirus/patologia , Edema/etiologia , Encefalite/etiologia , Encefalite/patologia , Enterovirus Humano B/isolamento & purificação , Hemorragia Gastrointestinal/mortalidade , Hepatite Viral Humana/etiologia , Humanos , Intestino Delgado/patologia , Fígado/patologia , Fígado/ultraestrutura , Linfangiectasia Intestinal/etiologia , Linfangiectasia Intestinal/patologia , Masculino , Otite Média/patologiaRESUMO
Patients with deficient antibody-mediated immunity may develop a rare "dermatomyositis-like" syndrome, which is usually progressive and fatal. We have observed a child with hypogammaglobulinemia in whom a dermatomyositis-like syndrome was associated with a fatal, disseminated ECHO 24 infection. This association suggests that in some immunodeficient patients the fatal dermatomyositis-like syndrome is a manifestation of a viral infection in a compromised host. The use of maternal plasma, with a high titer of ECHO 24 neutralizing activity, was unsuccessful in arresting the progress of the infection.