RESUMO
INTRODUCTION: Risk factors and outcomes of sexually-acquired human immunodeficiency virus infection were characterized in Jamaican children and adolescents. METHODOLOGY: Management was carried out by multidisciplinary teams in Infectious Diseases clinics during August 2003 through February 2019 using modified World Health Organization HIV criteria. RESULTS: There were 78 clients, aged 6 to 19 years, with females:males = 4:1 (p < 0.05). Sexual-initiation occurred in 60%, 47 before < 16 years (median 13 years, with four < 10 years; females:males = 7:1). Sexual-initiation preceded HIV diagnosis in all cases (median 2 years). Secondary education 93% (69/77) and living with non-parental relatives 17% (13/78) were associated with early sexual-initiation (p < 0.042); as was later imprisonment in 6% (3/52). Other sexually transmitted infections 36% (19/53) were associated with sexual-initiation ≥ 16 years (p < 0.01). Risks for ongoing HIV-transmission included infrequent condom use 74% (39/53), body-piercings 50% (24/48), illicit drug use 37% (28/76), tattoos 36% (19/52), transactional sex 14% (7/53) and pregnancy 56% of girls. 77% (59/77) had Centres for Diseases Control's Category A HIV infection; 82% (61/75) initiated anti-retroviral therapy; 75% (56/75) had first-line drugs, with helper T lymphocyte counts ≥ 500 cells/µL in 61% (48/78) and HIV viral load of < 1,000 copies/µL in 63% (40/64). Complications included dermatological 39% (20/52), respiratory 25% (13/52) and neurological 15% (8/52). Early sexual initiation was associated with depression 43% (33/76; p < 0.004) and suicidal attempt or ideation 23% (18/77; p < 0.096). Four (5%) died. CONCLUSIONS: Sexually transmitted HIV/AIDS in children and adolescents should preempt prompt medical, legal and psychosocial interventions.
Assuntos
Infecções por HIV/epidemiologia , Infecções por HIV/transmissão , Delitos Sexuais/estatística & dados numéricos , Adolescente , Criança , Abuso Sexual na Infância/estatística & dados numéricos , Feminino , Infecções por HIV/etiologia , Humanos , Jamaica/epidemiologia , Masculino , Fatores de Risco , Doenças Virais Sexualmente Transmissíveis/epidemiologia , Doenças Virais Sexualmente Transmissíveis/etiologia , Doenças Virais Sexualmente Transmissíveis/transmissão , Adulto JovemRESUMO
Psychostimulant use is a major comorbidity in people living with HIV, which was initially explained by them adopting risky behaviors that facilitate HIV transmission. However, the effects of drug use on the immune system might also influence this phenomenon. Psychostimulants act on peripheral immune cells even before they reach the central nervous system (CNS) and their effects on immunity are likely to influence HIV infection. Beyond their canonical activities, classic neurotransmitters and neuromodulators are expressed by peripheral immune cells (e.g., dopamine and enkephalins), which display immunomodulatory properties and could be influenced by psychostimulants. Immune receptors, like Toll-like receptors (TLRs) on microglia, are modulated by cocaine and amphetamine exposure. Since peripheral immunocytes also express TLRs, they may be similarly affected by psychostimulants. In this review, we will summarize how psychostimulants are currently thought to influence peripheral immunity, mainly focusing on catecholamines, enkephalins and TLR4, and shed light on how these drugs might affect HIV infection. We will try to shift from the classic CNS perspective and adopt a more holistic view, addressing the potential impact of psychostimulants on the peripheral immune system and how their systemic effects could influence HIV infection.
Assuntos
Doenças Transmissíveis/etiologia , Suscetibilidade a Doenças , Interações Hospedeiro-Patógeno/efeitos dos fármacos , Interações Hospedeiro-Patógeno/imunologia , Sistema Imunitário/efeitos dos fármacos , Animais , Biomarcadores , Estimulantes do Sistema Nervoso Central/efeitos adversos , Doenças Transmissíveis/epidemiologia , Doenças Transmissíveis/metabolismo , Suscetibilidade a Doenças/imunologia , Infecções por HIV/etiologia , Infecções por HIV/metabolismo , Humanos , Imunidade/efeitos dos fármacos , Imunomodulação , Vigilância da População , Subpopulações de Linfócitos T/imunologia , Subpopulações de Linfócitos T/metabolismo , Receptores Toll-Like/metabolismoRESUMO
BACKGROUND: Cartagena, Colombia's main port on the Caribbean Coast, reported an HIV incidence of 7.5 per 100,000 inhabitants in 2007 with 90.0% transmission by heterosexual contact and 70 identified as women with a stable partner. Studies across Colombia illustrate that HIV infection relates to social inequalities; most people with HIV live in poverty and have minimal access to health care, education, and secure jobs. The purpose of this article is to analyse the relationship between social inequalities, sexual tourism and HIV infection in Cartagena, Colombia. METHODS: Data come from a five-year participatory ethnography of HIV in Cartagena in the period 2004-2009, in which 96 citizens (30 of whom were living with HIV) participated in different data collection phases. Techniques included participant observation, in-depth interviews and thematic life histories. Out of this material, we selected three life histories of two women and a man living with HIV that are representative of the ways in which participants expressed how social inequalities make it virtually impossible to engage in safe sex practices. RESULTS: At stake is the exchange of condomless sex for goods within the widespread sexual tourism networks that promote an idealisation of dark-skinned men and women as better sexual performers. Our results illustrate the complex interplay of social inequalities based on class, skin colour, gender and sexual orientation. Furthermore, they suggest a synergistic effect between poverty, racialization, and gender inequalities in the historical maintenance of social dynamics for a fruitful growth of a sexual tourism industry that in turn increases vulnerability to HIV infection. CONCLUSIONS: Although the convergence of social inequalities has been thoroughly reported in the literature on social studies of HIV vulnerability; distinctive dynamics are occurring in Cartagena, including a clear link between the contemporary globalised sexual tourism industries and a racialised social structure - both having historical roots in the colonial past-.
Assuntos
Infecções por HIV/etiologia , Comportamento Sexual/estatística & dados numéricos , Infecções Sexualmente Transmissíveis/etiologia , Fatores Socioeconômicos , Viagem , Adulto , Antropologia Cultural , Colômbia/epidemiologia , Feminino , HIV , Infecções por HIV/epidemiologia , Infecções por HIV/virologia , Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Pobreza/estatística & dados numéricos , Infecções Sexualmente Transmissíveis/epidemiologia , Infecções Sexualmente Transmissíveis/virologiaRESUMO
Bone marrow stromal cell antigen 2 (BST2 or tetherin) is a host-encoded, interferon-inducible antiviral restriction factor which blocks the release of enveloped viruses. Few studies have assessed the role of BST2 polymorphisms on HIV-1 acquisition or disease progression in sub-Saharan Africa. This study investigated the frequency of four HIV-1-associated BST2 variants rs3217318, rs12609479, rs10415893 and rs113189798 in uninfected and HIV-1 infected black South Africans. Homozygosity for the rs12609479-A minor allele, previously associated with decreased HIV-1 acquisition risk, was underrepresented in HIV-1 uninfected black South Africans (2%) compared to reference African (9%) and in particular European populations (61%) (p = .047 and p < .0001, respectively). To determine if any of these gene variants influenced HIV-1 control in the absence of antiretroviral treatment (ART), we compared HIV-1 infected ART-naïve progressors [n = 72] and controllers [n = 71], the latter includes elite controllers [EC: n = 23; VL < 50 RNA copies/ml]. Heterozygosity for the rs12609479 SNP (G/A) was enriched in progressors compared to ECs (47.2% vs 21.7%, OR = 3.50 [1.16-10.59], p = .03), while rs113189798 heterozygosity (A/G) showed a strong trend of overrepresentation in ECs compared to progressors (47.8% vs 26.4%, OR = 0.39 [0.14-1.04], p = .07). Heterozygosity for the promoter indel rs3217318 (i19/Δ19) was associated with a faster rate of CD4+ T-cell decline in progressors (p = .0134). Carriage of the rs3217318 (i19/Δ19), rs12609479 (G/G), rs10415893(G/A) and rs113189798 (A/G) combined genotype, denoted as i19Δ19 GG GA AG, was associated with significantly higher CD4+ T-cell counts in progressors (p = .03), a finding predominantly driven by the _GG_AG combination. Our data suggest that the possession of select BST2 genotype combinations may be implicated in HIV-1 disease progression and natural spontaneous control.
Assuntos
Antígenos CD/genética , População Negra/genética , Suscetibilidade a Doenças , Variação Genética , Infecções por HIV/etiologia , HIV-1 , Adulto , Idoso , Alelos , Feminino , Proteínas Ligadas por GPI/genética , Frequência do Gene , Predisposição Genética para Doença , Genótipo , Infecções por HIV/epidemiologia , Infecções por HIV/prevenção & controle , Humanos , Desequilíbrio de Ligação , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético , Polimorfismo de Nucleotídeo Único , América do Sul/epidemiologia , Adulto JovemRESUMO
BACKGROUND: People who inject drugs (PWID) are at elevated risk of HIV infection. Data on population sizes of PWID living with HIV are needed to inform the implementation of prevention, treatment and care programs. We estimated national population sizes of people who recently (past 12 months) injected drugs living with HIV and evaluated ecological associations with HIV prevalence in PWID. METHODS: We used national data on the prevalence of injecting drug use and of HIV among PWID, derived from systematic reviews, to estimate national population sizes of PWID living with HIV. Uncertainty was estimated using Monte Carlo simulation with 100,000 draws. We extracted data on sample characteristics from studies of HIV prevalence among PWID, and identified national indicators that have been observed or hypothesised to be associated with HIV prevalence in PWID. We used linear regression to evaluate associations between these variables and HIV prevalence in PWID. RESULTS: Four countries comprised 55% of the estimated global population of PWID living with HIV: Russia (572,500; 95% uncertainty interval (UI) 235,500-1,036,500); Brazil (462,000; 95% UI 283,500-674,500); China (316,500; 95% UI 171,500-493,500), and the United States (195,500; 95% UI 80,000-343,000). Greater anti-HCV prevalence and national income inequality were associated with greater HIV prevalence in PWID. CONCLUSION: The countries with the largest populations of PWID living with HIV will need to dramatically scale up prevention, treatment and care interventions to prevent further increases in population size. The association between anti-HCV prevalence and HIV prevalence among PWID corroborates findings that settings with increasing HCV should implement effective interventions to prevent HIV outbreaks. The association between income inequality and HIV among PWID reinforces the need to implement structural interventions alongside targeted individual-level strategies.
Assuntos
Infecções por HIV/epidemiologia , Abuso de Substâncias por Via Intravenosa , Brasil/epidemiologia , China/epidemiologia , Infecções por HIV/etiologia , Humanos , Densidade Demográfica , Prevalência , Fatores de Risco , Federação Russa/epidemiologia , Inquéritos e Questionários , Revisões Sistemáticas como Assunto , Estados Unidos/epidemiologiaRESUMO
BACKGROUND AND OBJECTIVES: Methamphetamine (meth) use and its related risk behaviors for HIV among men who have sex with men (MSM) are a public health concern across the Mexico-US border. This study aims to contribute to the limited literature of meth use and sexual risk behaviors among Latino MSM on the Mexico-US border. METHODS: Data were drawn from the Meth Pilot Study (2014-2015) among men who use meth (n = 100). Descriptive statistics and bivariate analysis comparing MSM to non-MSM were conducted using Pearson's χ2 test, Fisher's exact tests, and Mann-Whitney U test; all tests were conducted using SPSS v.25. RESULTS: Most participants obtained meth in El Paso, Texas (87.2%), used meth orally (65.2%) or smoked (78.3%), and the most common reason for initiation was curiosity. Significant differences (P < .05) in meth use behaviors and sexual risk behaviors between MSM and non-MSM who used meth included: median number of sex partners (7 vs 3), being penetrated anally by last sexual partner (31.6% vs 1.4%), and engaging in transactional sex ever (63.2% vs 9.6%) and past 12 months (52.6% vs 6.8%). Finally, rates of HIV positivity were higher among MSM than non-MSM (10.5% vs 1.4%). DISCUSSION AND CONCLUSIONS: Among men who use meth, MSM are engaging in higher HIV risk behaviors compared with non-MSM. Understanding these risks could help identify candidates for pre-exposure prophylaxis (PrEP) and evidence-based substance use disorder treatment options. SCIENTIFIC SIGNIFICANCE: This study reveals that Latino MSM who use meth is a high-risk group for HIV and a need for tailored interventions. (Am J Addict 2020;29:111-119).
Assuntos
Transtornos Relacionados ao Uso de Anfetaminas/psicologia , Hispânico ou Latino/psicologia , Homossexualidade Masculina/psicologia , Drogas Ilícitas , Metanfetamina , Assunção de Riscos , Sexo sem Proteção/psicologia , Adulto , Transtornos Relacionados ao Uso de Anfetaminas/complicações , Estudos Transversais , Infecções por HIV/epidemiologia , Infecções por HIV/etiologia , Infecções por HIV/prevenção & controle , Infecções por HIV/psicologia , Humanos , Masculino , México , Pessoa de Meia-Idade , Projetos Piloto , TexasRESUMO
Purpose: The purpose of this study was to explore risk factors for HIV and sexually transmitted infections (STIs) among transgender women (TW) in Lima, Peru. Methods: HIV-negative or serostatus unknown TW reporting recent condomless receptive anal intercourse underwent testing for STIs and HIV and completed a sociobehavioral survey. Results: Among 120 TW, 29.6% had rectal Neisseria gonorrhoeae (GC) or Chlamydia trachomatis (CT) and 12.6% had HIV. Age and migrant status were associated with rectal GC/CT, and rectal GC/CT predicted HIV infection. Conclusions: Further study is needed to understand individual and social factors that contribute to HIV/STI vulnerability among TW.
Assuntos
Chlamydia trachomatis/crescimento & desenvolvimento , HIV/crescimento & desenvolvimento , Neisseria gonorrhoeae/crescimento & desenvolvimento , Doenças Retais/etiologia , Comportamento Sexual , Infecções Sexualmente Transmissíveis/epidemiologia , Pessoas Transgênero , Adolescente , Adulto , Fatores Etários , Canal Anal , Infecções por Chlamydia/epidemiologia , Infecções por Chlamydia/etiologia , Infecções por Chlamydia/microbiologia , Preservativos , Feminino , Gonorreia/epidemiologia , Gonorreia/etiologia , Gonorreia/microbiologia , Infecções por HIV/epidemiologia , Infecções por HIV/etiologia , Infecções por HIV/virologia , Humanos , Pessoa de Meia-Idade , Peru/epidemiologia , Doenças Retais/epidemiologia , Doenças Retais/microbiologia , Doenças Retais/virologia , Reto/microbiologia , Reto/virologia , Fatores de Risco , Infecções Sexualmente Transmissíveis/etiologia , Infecções Sexualmente Transmissíveis/microbiologia , Infecções Sexualmente Transmissíveis/virologia , Migrantes , Sexo sem Proteção , Adulto JovemRESUMO
INTRODUCTION: Knowledge about risky sexual behavior among young people has been widely acknowledged as a key tool to controlling the spread of HIV. This article aimed at presenting the risk behavior of Brazilian Army conscripts toward HIV infection according to the country's geographic regions. . METHOD: We collected data from 37,282 conscripts, aged 17 to 22, during enlistment in the Brazilian Army in 2016. The prevalence of HIV infection, both self-reported and measured through laboratory results, and risk behavior factors were estimated by region. RESULTS: 75% of the sample of conscripts reported to have already started sexual activity, and the average age of their sexual initiation was 15. Condom use varied according to the type of sexual relationship, being lower among steady partners and greater among less stable relationships. HIV prevalence assessed by laboratory tests was 0.12% across the country and the highest prevalence was observed in the North region (0.24%). Alcohol and illicit drug usage was higher in the South region. DISCUSSION: The study allowed the observation of risk behavior monitoring for HIV infection among young Brazilians. Lower condom usage among steady partners may be contributing to an increase in the number of HIV-infected individuals. CONCLUSION: Results suggest the need to intensify prevention campaigns to disseminate safe sex practices among young people, in addition to the expansion of testing offer to this population.
Assuntos
Infecções por HIV/etiologia , Comportamentos de Risco à Saúde , Militares/estatística & dados numéricos , Adolescente , Adulto , Consumo de Bebidas Alcoólicas/efeitos adversos , Consumo de Bebidas Alcoólicas/epidemiologia , Brasil/epidemiologia , Preservativos/estatística & dados numéricos , Estudos Transversais , Geografia , Infecções por HIV/epidemiologia , Humanos , Masculino , Prevalência , Medição de Risco , Fatores de Risco , Comportamento Sexual/estatística & dados numéricos , Transtornos Relacionados ao Uso de Substâncias/complicações , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Adulto JovemRESUMO
Introducción: La fascitis necrotizante es una infección progresiva poco común, con alta letalidad que puede afectar a cualquier parte del cuerpo, pero es más frecuente en las extremidades, en especial en las piernas, causada en su mayoría por una infección polimicrobiana y se caracteriza por afectar la fascia superficial, tejido subcutáneo, grasa subcutánea con nervios, arterias, venas y fascia profunda. Objetivo: Reportar el caso de una puérpera diagnosticada de fascitis necrotizante. Presentación de caso: Puérpera de 28 años de edad con antecedentes de obesidad e infección por VIH, ingresada en el Servicio de Obstetricia en un hospital de la República Sudafricana, por presentar fiebre, escalofríos y dolor en el abdomen. Se utilizó tratamiento endovenoso con antibióticos y tratamiento quirúrgico. Resultados: Evolución satisfactoria de la paciente sin secuelas. Conclusiones: El diagnóstico oportuno de esta patología permite un accionar temprano, con la consecuente sobrevida de los pacientes(AU)
Introduction: Necrotizing fasciitis is a very lethal uncommon progressive infection that can affect any part of the body, however it is more frequent in the limbs, especially the legs, caused mostly by a polymicrobial infection. It affects the superficial fascia, subcutaneous tissue, subcutaneous fat with nerves, arteries, veins and deep fascia. Objective: To report the case of a puerpera diagnosed with necrotizing fasciitis. Case presentation: A 28-year-old woman with a history of obesity and HIV infection, was admitted to the Obstetrics Service at a hospital in the Republic of South Africa. She had fever, chills and pain in the abdomen. Intravenous treatment with antibiotics and surgical treatment was used. Results: Satisfactory evolution of the patient with no sequelae. Conclusions: The opportune diagnosis of this pathology allows acting early, with the consequent survival of the patients(AU)
Assuntos
Humanos , Feminino , Adulto , Infecção Puerperal/prevenção & controle , Infecções por HIV/etiologia , Fasciite Necrosante/complicações , Fasciite Necrosante/tratamento farmacológico , Desbridamento/métodosRESUMO
HIV prevalence among transgender women is disproportional when compared to the general population in various countries. Stigma and discrimination based on gender identity have frequently been associated with vulnerability to HIV/AIDS. The objective was to conduct a systematic literature review to analyze the relationship between stigma and discrimination related to gender identity in transgender women and vulnerability to HIV/AIDS. This systematic literature review involved the stages of identification, compilation, analysis, and interpretation of results of studies found in five databases: PubMed, Scopus, Web of Science, Science Direct, and LILACS. No publication time period was determined in advance for this review. The studies were assessed according to the inclusion and exclusion criteria. The review included articles in English, Portuguese, or Spanish that related stigma and discrimination to transgender women's vulnerability to HIV. We found 41 studies, mostly qualitative, published from 2004 to 2018, and categorized in three dimensions of stigma: individual, interpersonal, and structural. The data highlighted that the effects of stigma related to gender identity, such as violence, discrimination, and transphobia, are structuring elements in transgender women's vulnerability to HIV/AIDS. The studies showed a relationship between stigma and discrimination and transgender women's vulnerability to HIV/AIDS and indicated the need for public policies to fight discrimination in society.
A prevalência de HIV entre mulheres transgênero é desproporcional quando comparamos com a população geral em vários países. O estigma e a discriminação, por conta da identidade de gênero, têm sido comumente associados à vulnerabilidade ao HIV/aids. O objetivo foi realizar uma revisão sistemática da literatura para analisar a relação entre o estigma e a discriminação relacionados à identidade de gênero de mulheres transgênero e à vulnerabilidade ao HIV/aids. Revisão sistemática da literatura, que envolveu as etapas de identificação, fichamento, análise e interpretação de resultados de estudos valendo-se da seleção em cinco bases: PubMed, Scopus, Web of Science, Science Direct e LILACS. Não houve estabelecimento de período de tempo a priori para essa revisão. Os estudos foram avaliados de acordo com critérios de inclusão e exclusão. Foram incluídos artigos em inglês, português ou espanhol, que relacionavam o estigma e a discriminação com a vulnerabilidade de mulheres transgênero ao HIV. Foram encontrados 41 artigos, majoritariamente qualitativos, publicados no período entre 2004 e 2018, e categorizados em três dimensões do estigma: nível individual, interpessoal e estrutural. Os dados permitem destacar que os efeitos do estigma relacionado à identidade de gênero, como a violência, a discriminação e a transfobia, são elementos estruturantes no processo da vulnerabilidade da população de mulheres transgênero ao HIV/aids. Os trabalhos mostraram relação entre estigma e discriminação com a vulnerabilidade de mulheres transgênero ao HIV/aids e apontaram para a necessidade de políticas públicas que combatam a discriminação na sociedade.
La prevalencia de VIH entre mujeres transgénero es desproporcionada cuando la comparamos con la población general en varios países. El estigma y la discriminación, debido a la identidad de género, han sido comúnmente asociados a la vulnerabilidad al VIH/SIDA. El objetivo fue realizar una revisión sistemática de la literatura para analizar la relación entre el estigma y la discriminación, relacionados con la identidad de género de mujeres transgénero y su vulnerabilidad al VIH/SIDA. Se realizó una revisión sistemática de la literatura, que implicó etapas de identificación, registro, análisis e interpretación de resultados de estudios, a partir de una selección en cinco bases de datos: PubMed, Scopus, Web of Science, Science Direct y LILACS. No se estableció un período de tiempo a priori para esta revisión. Los estudios se evaluaron según criterios de inclusión y exclusión. Se incluyeron artículos en inglés, portugués o español, que relacionaban el estigma y la discriminación con la vulnerabilidad de mujeres transgénero al VIH. Se encontraron 41 artículos, mayoritariamente cualitativos, publicados durante el período entre 2004 a 2018, y categorizados en tres dimensiones del estigma: nivel individual, interpersonal y estructural. Los datos permitieron destacar que los efectos del estigma, relacionado con la identidad de género, como la violencia, la discriminación y la transfobia, son elementos estructuradores en el proceso de la vulnerabilidad de la población de mujeres transgénero al VIH/SIDA. Los estudios mostraron una relación entre estigma y discriminación con la vulnerabilidad de mujeres transgénero al VIH/SIDA y señalan la necesidad de políticas públicas que combatan esta discriminación en la sociedad.