RESUMO
The aim of this study was to integrate the available data published on Liposarcomas (LPSs) of the oral cavity into an analysis of its clinical features, treatment modalities, and prognostic factors. An electronic search was undertaken in January 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Forty-five publications (104 LPSs) were included. The lesion was more prevalent in males from the fifth to seventh decades of life. Treatment (P = .03) and distant metastasis (P = .0001) were independently associated with survival. A lower possibility of recurrence was statistically associated with age (younger patients) (P = .03), tumor size (smaller than 2.8 cm) (P = .001), and treatment (radical surgery) (P = .04). LPS presents a good survival for patients after 5 years of follow-up (66.4%). Patients who were treated with conservative surgery and presented with distant metastasis showed poor prognosis.
Assuntos
Lipossarcoma , Recidiva Local de Neoplasia , Humanos , Lipossarcoma/epidemiologia , Lipossarcoma/terapia , Masculino , Boca , Recidiva Local de Neoplasia/epidemiologia , PrognósticoRESUMO
INTRODUCTION: Retroperitoneal sarcomas are a rare group of malignant soft tissue tumors with a generally poor prognosis. The aim of the study was to define the demographic characteristics and prognostic factors for patients with retroperitoneal sarcomas (RPS) in a Tertiary Referral Center at Mexico. METHODS: A retrospective study of patients with RPS treated from January 2005 to December 2012 at the National Cancer Institute at Mexico. Patient, tumor and treatment variables were analyzed including use of adjuvant therapy and survival status. Survival and local recurrence curves were estimated using the Kaplan-Meier method. RESULTS: Ninety-five patients with a mean age of 47 years with retroperitoneal sarcoma were included. Median follow-up was 25 months (range 1-108 months). The average tumor size was 23.7 cm. Histology, 58 (61.1%) were liposarcoma, 14 (14.7%), leiomyosarcomas and 23 (24.2%) were from other histologies. In 64 (67.4%) patients were high-grade malignancies. The median survival was 51 months for patients with complete resection, 25.1 months for those with incomplete resection, and 4.4 months for those with unresectable tumors. Complete resection (p = 0.0001), and liposarcoma (p = 0.03) were prognostic factors for overall survival. CONCLUSION: In this study of patients with retroperitoneal, complete resection and liposarcoma histology are prognostic factors related to the disease-free and overall survival. Patients approached with curative intent should undergo aggressive attempts at complete surgical resection.
Assuntos
Neoplasias Retroperitoneais/mortalidade , Sarcoma/mortalidade , Adulto , Terapia Combinada , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Leiomiossarcoma/mortalidade , Leiomiossarcoma/patologia , Leiomiossarcoma/terapia , Lipossarcoma/mortalidade , Lipossarcoma/patologia , Lipossarcoma/terapia , Masculino , México , Pessoa de Meia-Idade , Gradação de Tumores , Recidiva Local de Neoplasia/mortalidade , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/terapia , Prognóstico , Neoplasias Retroperitoneais/patologia , Neoplasias Retroperitoneais/terapia , Estudos Retrospectivos , Sarcoma/patologia , Sarcoma/terapia , Taxa de Sobrevida , Centros de Atenção Terciária , Resultado do TratamentoRESUMO
The purpose of this study is report a child with periorbital liposarcoma describing the clinical, epidemiological and therapeutic aspects. Six-months-old female baby with increasing tumor in the right fronto-zigomatic region wich was submitted to excision and the patologic and immunohistochemistry analisys observed typical findings of lipoblastoma. After that, there were three tumors relapse with the same diagnosis. One year after the last surgery there was a recurrence of the tumor but at this time the diagnosis was lipossarcoma and the patient was referred for additional treatment wilth radiotherapy and chemotherapy no new injuries so far Due to its rarity, liposarcoma usually does not enter the differencial diagnosis in the patients with orbital masses, however because of its local aggressiveess, it's vital the early identification and treatment to provide better therapeutic results and quality of life.
Assuntos
Lipossarcoma/patologia , Neoplasias Orbitárias/patologia , Diagnóstico Diferencial , Feminino , Humanos , Lactente , Lipossarcoma/terapia , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/terapia , Neoplasias Orbitárias/terapia , Reoperação , Resultado do TratamentoRESUMO
O objetivo desse estudo é descrever uma criança com lipossarcoma periorbital, caracterizando seus aspectos clínico-epidemiológicos e terapêuticos. Menina de 6 meses de idade com tumoração crescente há dois meses em região fronto-zigomática direita, a qual foi submetida à exérese e cujas análises anatomopatológica (AP) e imuno-histoquímica (IH) observaram achados típicos de lipoblastoma. Após isso, apresentou mais três recidivas tumorais com diagnósticos similares. Um ano depois da última cirurgia, houve nova recorrência, porém, dessa vez, o resultado dos exames análises anatomopatológica e imuno-histoquímica foi de lipossarcoma, sendo, então, encaminhada para complementar o tratamento com radio e quimioterapia, sem novas lesões até o momento. Devido a sua raridade, geralmente o lipossarcoma não entra no diagnóstico diferencial em pacientes com massas orbitais, porém, por ser localmente agressivo, torna-se vital a pronta identificação e tratamento de forma a oferecer melhores resultados terapêuticos e influência sobre a qualidade de vida do paciente.
The purpose of this study is report a child with periorbital liposarcoma describing the clinical, epidemiological and therapeutic aspects. Six-months-old female baby with increasing tumor in the right fronto-zigomatic region wich was submitted to excision and the patologic and immunohistochemistry analisys observed typical findings of lipoblastoma. After that, there were three tumors relapse with the same diagnosis. One year after the last surgery there was a recurrence of the tumor but at this time the diagnosis was lipossarcoma and the patient was referred for additional treatment wilth radiotherapy and chemotherapy no new injuries so far Due to its rarity, liposarcoma usually does not enter the differencial diagnosis in the patients with orbital masses, however because of its local aggressiveess, it's vital the early identification and treatment to provide better therapeutic results and quality of life.
Assuntos
Feminino , Humanos , Lactente , Lipossarcoma/patologia , Neoplasias Orbitárias/patologia , Diagnóstico Diferencial , Lipossarcoma/terapia , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/terapia , Neoplasias Orbitárias/terapia , Reoperação , Resultado do TratamentoRESUMO
BACKGROUND: Soft tissue sarcomas are rare tumors with a wide clinical spectrum. Prognostic factors for survival have been identified, but they have been focused in the characteristics of the tumor. Patient related variables have not usually been considered in previous analysis. METHODS: We analyzed a group of 61 patients with soft tissue sarcomas. Tumor related variables and patient related ones were recorded. Overall and disease free survival were calculated according to the Kaplan and Meier method. Prognostic factors for survival were determined by the log-rank method for univariate analysis and the Cox method for multivariate analysis. RESULTS: Clinical and demographic characteristics are comparable to those of previous reports. Adverse prognostic factors for overall survival in multivariate analysis were advanced stage, high tumor grade, irresecability, and serum albumin. Size, high surgical risk (ASA III-IV) and a low performance status (Karnofsky less than 70) were predictive of overall survival only in univariate analysis. For disease free survival, only high tumor grade had statistical significance. CONCLUSIONS: Besides the usual tumor related prognostic factors, such as grade and stage, patient related factors, such as performance status and surgical risk should be considered when predicting survival. Specifically, serum albumin was an independent prognostic factor for overall survival.
Assuntos
Sarcoma/sangue , Albumina Sérica/análise , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores , Caquexia/sangue , Caquexia/etiologia , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Lipossarcoma/sangue , Lipossarcoma/mortalidade , Lipossarcoma/terapia , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Sarcoma/complicações , Sarcoma/mortalidade , Sarcoma/terapia , Análise de Sobrevida , Adulto JovemRESUMO
Here, we describe the case of a 51-year-old female with mediastinal liposarcoma. Liposarcoma is the most common malignant mesenchymal neoplasm in adults, although a mediastinal location is extremely rare. It has a large volume and varied histologic subtypes. It is characterized by the compression of neighboring structures. Computed tomography and magnetic resonance imaging provide useful data for diagnosis. Tissue biopsy and histological typing are very important in determining the treatment and are needed for the final diagnosis. Radiotherapy and chemotherapy are ineffective treatment modalities. According to the literature, surgical resection is the treatment of choice. Long-term follow-up evaluation is indicated since there is a high rate of recurrence.
Assuntos
Lipossarcoma/diagnóstico , Neoplasias do Mediastino/diagnóstico , Quimioterapia Adjuvante , Feminino , Humanos , Lipossarcoma/terapia , Espectroscopia de Ressonância Magnética , Neoplasias do Mediastino/terapia , Pessoa de Meia-Idade , Radioterapia AdjuvanteRESUMO
Relatamos o caso de uma mulher de 51 anos com lipossarcoma mediastinal. O lipossarcoma é a neoplasia mesenquimal maligna mais comum em adultos, embora sua localização mediastinal seja extremamente rara. Ele possui grande volume e variados subtipos histológicos. É caracterizado pela compressão de estruturas vizinhas. A tomografia computadorizada e a ressonância magnética fornecem informações úteis para o diagnóstico.A biopsia tecidual e a identificação do tipo histológico são importantes na determinação da terapia e são necessárias para o diagnóstico final. A radioterapia e a quimioterapia são modalidades terapêuticas ineficazes. De acordo com a literatura, a ressecção cirúrgica é o tratamento de escolha. Está indicado o acompanhamento a longo prazo, pois a taxa de recidiva é alta.
Here, we describe the case of a 51-year-old female with mediastinal liposarcoma. Liposarcoma is the most common malignant mesenchymal neoplasm in adults, although a mediastinal location is extremely rare. It has a large volume and varied histologic subtypes. It is characterized by the compression of neighboring structures. Computed tomography and magnetic resonance imaging provide useful data for diagnosis. Tissue biopsy and histological typing are very important in determining the treatment and are needed for the final diagnosis. Radiotherapy and chemotherapy are ineffective treatment modalities. According to the literature, surgical resection is the treatment of choice. Long-term follow-up evaluation is indicated since there is a high rate of recurrence.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Lipossarcoma/diagnóstico , Neoplasias do Mediastino/diagnóstico , Quimioterapia Adjuvante , Lipossarcoma/terapia , Espectroscopia de Ressonância Magnética , Neoplasias do Mediastino/terapia , Radioterapia AdjuvanteRESUMO
Liposarcoma of the lung is extremely rare with only 11 cases previously reported. A case of a locally advanced pulmonary pleomorphic liposarcoma in a 49-year-old male is presented. Surgery was performed but radical resection was not possible. Post-operative radiotherapy (40 Gy) was given concurrently with cisplatin (12.5 mg daily for 10 days). A partial response of short duration was obtained. The patient died 8 months following surgery with disseminated disease. Based on reports in the literature, liposarcoma of the lung must be classified as an aggressive highly metastatic disease responding poorly to both chemotherapy and radiotherapy.
Assuntos
Lipossarcoma/diagnóstico , Neoplasias Pulmonares/diagnóstico , Quimioterapia Adjuvante , Cisplatino/administração & dosagem , Evolução Fatal , Humanos , Lipossarcoma/terapia , Neoplasias Pulmonares/terapia , Masculino , Pessoa de Meia-IdadeRESUMO
A case of a male patient, 66 years old, who exhibited in a period of six years many multicentric and multifocal synchronic and metachronic myxoid liposarcomas is reported. The authors made a revision of cytogenetics and DNA alterations recently identified in this type of tumor. The chromosomic alterations are represented by the translocation t(12;16) (q13;p11) and trisomy of the chromosome 8. The genic analysis revealed the presence of altered restriction fragments due to highly specific and reproducible methylation differences. In conclusion the authors suggest that the presence of the multiple tumors of this type in the same patient could be due to a common etiologic factor, not yet known, as being the initiator of this systemic illness of the fat tissue.
Assuntos
Neoplasias Abdominais/terapia , Neoplasias de Cabeça e Pescoço/terapia , Lipossarcoma Mixoide/terapia , Lipossarcoma/terapia , Neoplasias Primárias Múltiplas/terapia , Segunda Neoplasia Primária/terapia , Neoplasias Pélvicas/terapia , Neoplasias Torácicas/terapia , Neoplasias Abdominais/diagnóstico , Idoso , Neoplasias de Cabeça e Pescoço/diagnóstico , Humanos , Lipossarcoma/diagnóstico , Lipossarcoma Mixoide/diagnóstico , Masculino , Neoplasias Primárias Múltiplas/diagnóstico , Segunda Neoplasia Primária/diagnóstico , Neoplasias Pélvicas/diagnóstico , Coxa da Perna , Neoplasias Torácicas/diagnóstico , Tomografia Computadorizada por Raios XRESUMO
Os autores apresentam a experiência da Clínica de Cirurgia Vascular do Hospital Naval Marcílio Dias na utilizaçäo das embolizaçöes terapêuticas em 12 pacientes portadores de patologias diversas. Dos doze pacientes, dez apresentaram bons resultados, em um o resultado foi considerado regular e em um o resultado foi considerado ruim. A complicaçäo mais séria consistiu em necrose isquêmica do colo direito após embolizaçäo de angiodisplasia. Os autores concluem que as E.T. constituem um método de grande valia em casos críticos onde a aplicaçäo dos procedimentos convencionais fica prejudicada