RESUMO
The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in Drosophila melanogaster was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis.
Assuntos
Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Drosophila melanogaster/efeitos dos fármacos , Ácido Elágico/farmacologia , Receptores Toll-Like/imunologia , Animais , Candida albicans/crescimento & desenvolvimento , Candida albicans/patogenicidade , Candidíase/tratamento farmacológico , Candidíase/imunologia , Candidíase/microbiologia , Modelos Animais de Doenças , Drosophila melanogaster/genética , Drosophila melanogaster/imunologia , Drosophila melanogaster/microbiologia , Feminino , Expressão Gênica , Heterozigoto , Longevidade/imunologia , Receptores Toll-Like/genéticaAssuntos
Longevidade/fisiologia , Adulto , Idoso , Envelhecimento , Animais , Apolipoproteína E3/genética , Apolipoproteína E3/imunologia , Apolipoproteína E4/genética , Aterosclerose/genética , Aterosclerose/história , Doenças Cardiovasculares/genética , Doenças Cardiovasculares/história , Dieta , Antigo Egito , Variação Genética/imunologia , História Antiga , Humanos , Imunidade/genética , Longevidade/genética , Longevidade/imunologia , Carne , Pessoa de Meia-Idade , Múmias , Pan troglodytes/fisiologia , Peru , Especificidade da EspécieRESUMO
The continuous global increase in life expectancy represents a central challenge for our society and impacts public social security systems, families and individuals. One of the most striking changes that occur during normal human aging is immunosenescence, a progressive and overall diminution of immune functions that affect all cells and organs of the innate and adaptive immune system. As a hallmark of human aging, the progressive involution of the thymus leads to a disturbed balance and function of naïve, memory and effector T cells, thus promoting a latent pro-inflammatory status in the elderly. Together with chronic infections such as cytomegalovirus, that accumulate during life, this situation manifests in clinically relevant implications such as poor overall immune responses, decreased ability to control infectious disease and diminished response to vaccinations. Interestingly, this process parallels changes in the hormonal balance of aging subjects. In this review, we summarize recently published intriguing results from a very active and growing field of biomedical research and discuss some clinical consequences as well as possible ways of immune- and/or hormone-based interventions to delay or reverse immunosenescence.