RESUMO

An improved method for the identification of butyrylcholinesterase phenotypes is proposed. It is based on modifications of a method that uses alpha-naphthyl acetate as substrate and DL-propranolol and Ro2-0683 as inhibitors. The proposed modifications make the method more rapid and increase the accuracy of the determinations of the phenotypes tested (BCHE U, BCHE UF, BCHE UA, BCHE AK, BCHE AF, and BCHE A). These modifications make the method even more adequate for population studies and clinical routine.

Assuntos

Alelos , Butirilcolinesterase/genética , Inibidores da Colinesterase/farmacologia , Humanos , Naftol AS D Esterase/farmacologia , Fenótipo , Propranolol/farmacologia , Compostos de Amônio Quaternário/farmacologia