RESUMO
Trichofolliculoma is a rare follicular hamartoma whose dermoscopic features have been scarcely reported. On the other hand, reflectance confocal microscopy features have not been described yet. In the present study, the authors report reflectance confocal microscopy features in a case of trichofolliculoma as squamous hyperplasia forming irregular finger-like protrusions around the hair follicle and papillomatous hyperplasia of the hair follicle epithelium, which correlated with histopathology. This case suggests that reflectance confocal microscopy may help incorrect in vivo diagnosis of trichofolliculoma in cases difficult to diagnose by morphology and dermoscopy.
Assuntos
Cisto Folicular , Neoplasia de Células Basais , Neoplasias Cutâneas , Dermoscopia , Cisto Folicular/diagnóstico por imagem , Cisto Folicular/patologia , Humanos , Microscopia Confocal , Neoplasia de Células Basais/patologia , Neoplasias Cutâneas/patologiaRESUMO
Resumen El colgajo retroauricular en isla (flip-flop flap) fue descrito por Masson en 1972 y consiste en tejido dermoepidérmico irrigado por un pedículo de patrón aleatorio subcutáneo de ramas de la arteria auricular posterior. Proviene de la región mastoidea y retroauricular y aporta buena cobertura para la región anteromedial del pabellón auricular. Se describen dos casos, en que se realizó cobertura inmediata secundario a un defecto de la concha auricular posterior a resección neoplásica, obteniendo resultados satisfactorios y sin complicaciones.
Abstract The retroauricular island flap (flip-flop flap), was described by Masson in 1972 and consists on dermoepidermal tissue irrigated by a random subcutaneous pedicle of branches of the posterior auricular artery. It comes from the mastoid and retroauricular region and provides a good coverage for the anteromedial region of the pinna. Two cases are described, in which immediate coverage was performed secondary to a defect in the auricular concha after a neoplastic resection, obtaining satisfactory results without complications.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Retalhos Cirúrgicos/cirurgia , Neoplasias da Orelha , Orelha Externa/patologia , Neoplasia de Células BasaisRESUMO
El adenocarcinoma de células basales, también conocido como carcinoma salival basaloide, adenoma maligno de células basales, es una neoplasia epitelial de bajo grado, infiltrante, localmente destructivo y con tendencia a ser recidivante. Su aparición es entre la 5ª y 6ª década de vida, sin predilección por sexo. Clínicamente se manifiesta con un edema o un aumento repentino de tamaño en la zona, de consistencia firme, crecimiento lento e indoloro. El diagnóstico de certeza es a través de la histopatología; su tratamiento quirúrgico, y tiene buen pronóstico en sus estadios iniciales (AU)
Basal cells adenocarcinoma also known as salivary basaloide carcinoma basal cells malignant adenoma is a low degree, infiltrating, locally destructive and prone to be relapsing, epithelial neoplasia. It occurs between the 5th and 6th decade of life, with no predilection for sex. Clinically it manifests with an edema or sudden increased size in the area, of firm consistency, slow growth and pain-less. Its treatment is surgical and the diagnosis of certainty is histopathological with a good prognosis. The purpose of this presentation is to show the case of a 57- years-old male patient with clinical and anatomopathological diagnosis of adenocarcinoma of basal cells located in the yugal mucosa (AU)
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/classificação , Adenocarcinoma/cirurgia , Adenocarcinoma/diagnóstico , Neoplasia de Células Basais , Prognóstico , Biópsia/métodos , Procedimentos Cirúrgicos Bucais/métodos , Diagnóstico Diferencial , Distribuição por Idade e Sexo , Mucosa Bucal/lesões , Recidiva Local de Neoplasia/prevenção & controleRESUMO
A proliferating pilar tumor is a rare skin neoplasm that arises from the outer root sheath of a hair follicle. Presentation varies widely, as the tumor can be benign or malignant and has a high probability of recurring after excision. We report our experience managing 3 proliferating pilar tumors with different clinical presentations and pathology findings at Hospital de San José, Bogota, Colombia.
Assuntos
Doenças do Cabelo/patologia , Folículo Piloso , Neoplasias de Cabeça e Pescoço/patologia , Couro Cabeludo , Neoplasias Cutâneas/patologia , Adulto , Idoso , Colômbia , Diagnóstico Diferencial , Feminino , Doenças do Cabelo/cirurgia , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Neoplasia de Células Basais/patologia , Neoplasias Cutâneas/cirurgiaRESUMO
RESUMEN Introducción: En Cuba, la introducción del HeberFERON para el tratamiento de neoplasias de piel no melanomas perioculares ha permitido respuestas clínicas y estéticas muy favorables, evitando cirugías y reconstrucciones complejas, obteniéndose resultados muy promisorios. Objetivo: Describir la respuesta al tratamiento con HeberFERON en pacientes con neoplasia basocelular desde el diagnóstico de enfermería. Métodos: Estudio descriptivo longitudinal prospectivo en el Servicio de Oftalmología del Hospital General Docente Abel Santamaría Cuadrado de Pinar del Río en el periodo julio-diciembre 2017. El universo estuvo constituido por 12 pacientes con neoplasia basocelular, tratados con HeberFERON. Las variables analizadas fueron: edad, sexo, fototipo de piel, localización y tamaño de la lesión, respuesta al tratamiento, diagnóstico de enfermería. Resultados: El 50,00 por ciento de los pacientes estudiados pertenecieron al grupo de edades de 71 y más, de sexo masculino, y la lesión tenía un tamaño de menos de 20 mm, el 66,66 por ciento fototipo de piel II , la lesión se localizaba en el parpado inferior y tuvieron una respuesta completa al tratamiento con el HeberFERON, el diagnóstico de enfermería de desconfianza e insuficiente conocimiento de su enfermedad estuvo en el 100,00 por ciento de los casos , temor a la muerte en el 91,66 por ciento, y el deterioro de la piel y los tejidos adyacentes en un 83,33 por ciento de los casos estudiados. Conclusiones: La mayoría de los pacientes tratados con HeberFERON presentaron una respuesta completa a la terapéutica utilizada, traducido en una desaparición completa de la neoplasia(AU)
ABSTRACT Introduction: In Cuba, HeberFERON introduction in the treatment of non-melanomas periocular skin neoplasms has allowed very favorable clinical and aesthetic outcomes, avoiding complex surgeries and reconstructions and obtaining very promising results. Objective: To describe the response to HeberFERON treatment in patients with basal cell neoplasia since the nursing diagnosis. Methods: Prospective, longitudinal and descriptive study carried out in the ophthalmology service of Abel Santamaría Cuadrado General Teaching Hospital of Pinar del Río, in the period from July to December 2017. The study population consisted of 12 patients with basal cell neoplasia and treated with HeberFERON. The variables analyzed were age, sex, skin phototype, location and size of the lesion, response to treatment, and nursing diagnosis. Results: 50.00 percent of the patients studied belonged to the age group of 71 years or older, of male sex, and whose lesion was less than 20 mm in size. 66.66 percent had a skin phototype II. The lesion was located in the lower eyelid and had a complete response to treatment with HeberFERON. Based on the nursing diagnosis, lack of confidence and knowledge about the disease was in 100 percent of the cases; fear of death, in 91.66 percent; deterioration of skin and tissues around, in 83.33 percent. Conclusions: The majority of the patients treated with HeberFERON presented a complete response to the therapy, resulting in a total disappearance of the neoplasm(AU)
Assuntos
Humanos , Masculino , Idoso , Diagnóstico de Enfermagem/estatística & dados numéricos , Neoplasia de Células Basais/tratamento farmacológico , Cuidados de Enfermagem/métodos , Epidemiologia Descritiva , Estudos Prospectivos , Estudos LongitudinaisRESUMO
Breast cancer is the most prevalent cancer among women, with the basal-like triple negative (TNBC) being the most agressive one, displaying the poorest prognosis within the ductal carcinoma subtype. Due to the lack of adequate molecular targets, the diagnosis and treatment of patients with the TNBC phenotype has been a great challenge. In a previous work, we identified CD90/Thy-1 as being highly expressed in the aggressive high malignancy grade Hs578T basal-like breast tumor cell line, pointing to this molecule as a promising breast tumor marker, which should be further investigated. Here, CD90 expression was analyzed in human breast cancer samples and its functional role was investigated to better assess the oncogenic nature of CD90 in mammary cells. Quantification of CD90 expression in human breast cancer samples, by tissue microarray, showed that high CD90 positivity correlates with metastasis and poor patient survival in the basal-like subtype. The functional genetic approach, by overexpression in the CD90 cDNA in a basal-like normal mammary cell line (MCF10A) and knockdown in a highly malignant cell line (Hs578T), allowed us to demonstrate that CD90 is involved with several cellular processes that lead to malignant transformation, such as: morphological change, increased cell proliferation, invasiveness, metastasis and activation of the EGFR pathway. Therefore, our results reveal that CD90 is involved with malignant transformation in breast cancer cell lines and is correlated with metastasis and poor patient survival in the basal-like subtype, being considered as a promising new breast cancer target.
Assuntos
Transformação Celular Neoplásica/genética , Expressão Gênica , Neoplasia de Células Basais/genética , Neoplasia de Células Basais/patologia , Antígenos Thy-1/genética , Animais , Biomarcadores Tumorais , Brasil , Linhagem Celular Tumoral , Movimento Celular , Transformação Celular Neoplásica/metabolismo , Fator de Crescimento Epidérmico/metabolismo , Transição Epitelial-Mesenquimal , Feminino , Imunofluorescência , Amplificação de Genes , Perfilação da Expressão Gênica , Humanos , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Neoplasia de Células Basais/mortalidade , Prognóstico , Ratos , Transdução de Sinais , Antígenos Thy-1/metabolismo , Análise Serial de TecidosRESUMO
Introducción: el carcinoma basocelular es la forma más común de cáncer de piel y el proceder quirúrgico es la elección para su tratamiento. Aparece más frecuente en áreas visibles o fotoexpuestas, por lo que en ocasiones, con el fin de preservar tejidos su resección es insuficiente; o por el contrario si se amplían a los márgenes establecidos, pudieran generar secuelas cicatrizales. La dermatoscopía es una técnica de fácil aplicación que permite previamente la visualización de los límites reales del tumor para así obtener márgenes quirúrgicos no comprometidos de menor tamaño que evitan posteriores deformidades estéticas. Objetivos: determinar la utilidad de la dermatoscopía para obtener márgenes quirúrgicos mínimos, libres de carcinomas basocelulares en cara y cuello, con posterior comprobación histológica. Materiales y Métodos: estudio observacional, descriptivo, en Hospital " Comandante Faustino Pérez Hernández" de la ciudad de Matanzas, a 21 pacientes, con diagnóstico clínico y dermatoscópico de carcinoma basocelular. Se les estableció mínimo margen quirúrgico a través de la dermatoscopía y posterior a ello, se comprobó histológicamente si los bordes de incisión estaban comprometidos o no. Resultados: el 95,5 % de los informes histopatológicos revelaron que las lesiones fueron bien resecadas. Conclusiones: el establecimiento dermatoscópico de un mínimo margen quirúrgico antes de la excéresis, constituye un método confiable para la obtención de lesiones bien resecadas, y disminuyen así las secuelas deformantes que provocan las cicatrices de las grandes incisiones en lesiones de cara y cuello (AU).
Introduction: the basal cell carcinoma is the most common form of skin cancer and the surgical procedure is the election for its treatment. It appears more frequently in visible or photo exposed areas, therefore, occasionally its resection is insufficient with the aim of preserving tissues, or because if it reaches the established margins it could generate scar sequels. Dermoscopy is an easily applicable technique allowing the previous visualization of the real limits of the tumor for obtaining surgical, noncompromised margins of less size that avoid subsequent esthetic deformities. Objectives: to determine the usefulness of dermoscopy for obtaining minimal surgical margins, free of basal cell carcinomas in the face and neck, with following histologic verification. Materials and Methods: observational, descriptive study carried out in the Hospital "Comandante Faustino Pérez Hernandez" of Matanzas, in 21 patients with clinical and dermoscopic of basal cell carcinoma. Through dermoscopy the minimal surgical margin was established and after that, it was checked histologically if the incision borders were compromised or not. Results: 95.5 % of the histopathological reports showed that the lesions were correctly resected. Conclusions: the dermoscopical establishment of a minimal surgical margin before the excision, is a reliable method for getting good resected lesions; that way, the deforming sequels caused by the scars of large incisions in lesions of the face and neck are reduced. (AU)