RESUMO
OBJECTIVE: The aim of this study is to determine the relative frequency, demographic distribution and clinicopathological features of pediatric oral and maxillofacial cancer (POMC). METHODS: Medical records were retrospectively reviewed for all cancer cases diagnosed from 1986 to 2016 affecting patients aged 19 years and younger. Demographic variables, anatomical site, and histopathological diagnoses were collected and analyzed by descriptive statistics. RESULTS: Fifty-five (0.77%) POMCs were found among 7181 pediatric malignancies. Mean age at diagnosis was 8 years and patients aged 5-9 years presented the higher prevalence of malignant tumors (40%). White male patients were more frequently affected (78.18% and 65.45%, respectively). The most common cancer type was lymphomas (52.73%) followed by sarcomas (27.27%) and carcinomas (20%). Burkitt lymphoma (32.73%), rhabdomyosarcoma (14.55%), diffuse large B-cell lymphoma (9.09%), and mucoepidermoid carcinoma (9.09%) were the most common histopathological diagnoses. The main affected anatomical site was the oropharynx (38.18%), followed by salivary glands (30.91%), maxillofacial bone (20%), and oral cavity (10.91%). CONCLUSION: POMC has a low incidence; however, highly aggressive tumors, such as lymphomas and sarcomas, are common in this scenario. A better knowledge about the clinicopathological distribution of POMC may contribute to early diagnosis and improve survival rates.
Assuntos
Carcinoma/epidemiologia , Neoplasias Faciais/epidemiologia , Linfoma/epidemiologia , Neoplasias Maxilares/epidemiologia , Neoplasias Bucais/epidemiologia , Sarcoma/embriologia , Adolescente , Adulto , Fatores Etários , Idoso , Brasil/epidemiologia , Carcinoma/patologia , Criança , Pré-Escolar , Neoplasias Faciais/patologia , Feminino , Humanos , Incidência , Lactente , Linfoma/patologia , Masculino , Neoplasias Maxilares/patologia , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Prevalência , Estudos Retrospectivos , Sarcoma/patologia , Taxa de Sobrevida , Adulto JovemRESUMO
OBJECTIVE: Our objective was to describe the clinicopathologic and immunohistochemical features of acute lymphoblastic leukemia/lymphoma (ALL/LBL) of the oral and maxillofacial region (OMF). STUDY DESIGN: Cases diagnosed as ALL/LBL of the OMF region were retrieved from the files of 2 Brazilian and 1 Guatemalan oral pathology services from 2005 to 2017. Microscopic and immunohistochemical features of each case were reviewed and fully described, and clinical data were retrieved from the pathology reports. RESULTS: During the period considered, 6 cases were identified. Male patients were the most affected (4:2), with a mean age of 19 years old. The mandible was involved in 2 cases, the maxilla in 2, the cheek mucosa in 1, and the parotid gland in 1. Painful swelling was the most common presentation, and 3 patients also had systemic complaints. Microscopically, tumors revealed solid infiltrations of small to medium-sized immature cells. "Puzzle-like" and "starry-sky" patterns were observed, and "single lane" growth was also identified. Immunohistochemically, 2 cases were diagnosed as T-cell ALL/LBL with the leukocyte common antigen (LCA)+/cCD3+/CD79 a+focal/CD20-/PAX5-/CD99+/CD34-/CD10+/terminal deoxynucleotidyl transferase (TdT)+ phenotype and 4 as B-cell ALL/LBL with the LCA+/CD3-/CD20-/CD79 a+/CD10+/CD34 variable/TdT+ predominant phenotype. The Ki67 index ranged from 80% to 99%. CONCLUSION: OMF ALL/LBL is rare, but its microscopic features and immunohistochemical profiles CD3+or CD79 a+/CD10+/CD34+variable/CD99+/TdT+ contribute to the correct diagnosis.
Assuntos
Neoplasias Faciais/patologia , Neoplasias Maxilomandibulares/patologia , Neoplasias Bucais/patologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia , Adolescente , Adulto , Brasil/epidemiologia , Neoplasias Faciais/epidemiologia , Feminino , Guatemala/epidemiologia , Humanos , Imuno-Histoquímica , Neoplasias Maxilomandibulares/epidemiologia , Masculino , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologiaRESUMO
OBJECTIVES: To investigate the frequency of malignant oral and maxillofacial lesions among children and adolescents from representative geographic regions of Brazil. MATERIALS AND METHODS: A retrospective study was conducted on biopsies obtained from 1990 to 2016 at six Brazilian oral and maxillofacial pathology referral centers. A total of 85,105 biopsy specimens from children and adolescents were analyzed. Gender, age, anatomical location, symptomatology and histopathological diagnosis were evaluated. Data were analyzed using descriptive statistical methods. RESULTS: Fifty-eight (0.06%) malignant oral and maxillofacial lesions were diagnosed in children (19%) and adolescents (81%). The lesions were more frequent among females (60.3%) and adolescents. The most prevalent lesions were mucoepidermoid carcinomas (22.4%), osteosarcomas (13.8%), squamous cell carcinomas (12.1%), and Burkitt's lymphomas (12.1%). The most commonly affected sites were the palate (19%), mandible (13.8%), and maxilla (13.8%). Almost half the patients were asymptomatic. CONCLUSION: Pediatric oral and maxillofacial malignant lesions were infrequent and showed wide diversity, with a prevalence of mucoepidermoid carcinomas. Analysis of malignant lesions in children and adolescents helps pediatric dentists and oncologists to obtain a better understanding of such lesions and to reduce the time for diagnosis, with a consequent improvement of prognosis.
Assuntos
Neoplasias Faciais/epidemiologia , Neoplasias Maxilares/epidemiologia , Neoplasias Bucais/epidemiologia , Adolescente , Fatores Etários , Doenças Assintomáticas , Brasil/epidemiologia , Linfoma de Burkitt/epidemiologia , Carcinoma Mucoepidermoide/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Criança , Pré-Escolar , Feminino , Neoplasias de Cabeça e Pescoço/epidemiologia , Humanos , Lactente , Recém-Nascido , Masculino , Osteossarcoma/epidemiologia , Prognóstico , Estudos Retrospectivos , Fatores Sexuais , Carcinoma de Células Escamosas de Cabeça e PescoçoRESUMO
RESUMEN: El grupo de neoplasias malignas de tejido blando de la región de cabeza y cuello en pacientes pediátricos está representado por carcinomas, sarcomas, melanomas y tumores de diferenciación incierta. La neoplasia más prevalente en la población pediátrica es el Rabdomiosarcoma, seguido por el carcinoma de células escamosas. Los rangos de presentación son muy amplios, siendo los grupos entre 2-6 años y 15-19 años los que presentan mayor incidencia. Se ha planteado que la etiología de estas neoplasias es incierta. El tratamiento de estas neoplasias es comúnmente de enfoque multimodal, combinando un procedimiento quirúrgico con quimioterapia y radioterapia. El pronóstico y sobrevida del paciente dependerán principalmente del momento en que se realice el diagnóstico de la lesión. Un diagnóstico y tratamiento temprano favorecen las posibilidades de sobrevida y el pronóstico del paciente. Este estudio corresponde a la 3ra parte de "Cáncer bucomaxilofacial en niños". Se hará referencia a los distintos tumores malignos del tejido blando en la población pediátrica en el territorio de cabeza y cuello, abarcando sus generalidades, etiología, epidemiología, tratamiento y pronóstico.
ABSTRACT: Head and neck malignant tumors in pediatric patients comprise carcinoma, sarcoma, melanoma and tumours of uncertain differentiation. Within the pediatric population, the most prevalent neoplasm is rhabdomyosarcoma, followed by squamous cell carcinoma. There is a wide range in the presentation, and it varies significantly with age groups of 2-6 and 15-19 year-olds who present the higher incidence rates. For this reason, it has been suggested that the etiology of head and neck neoplasms remains unclear. Treating these pathologies usually involves a multimodal approach that combines surgery, radiation and chemotherapy. Prognosis and survival rates depend mainly of the stage at the time of diagnosis. Early diagnosis and treatment can improve prognosis and survival rates. In this 3rd part of "Maxillofacial Cancer in Pediatric Patients", we studied a variety of malignant tumors in head and neck soft tissue from a paediatric sample. Specifically, we aim to analyze their etiology, epidemiology, treatment and prognosis.
Assuntos
Humanos , Criança , Adolescente , Neoplasias Faciais/epidemiologia , Neoplasias Bucais/etiologia , Neoplasias Bucais/epidemiologia , Carcinoma/epidemiologia , Neoplasias Maxilares/epidemiologia , Prognóstico , Sarcoma/epidemiologia , Neoplasias Maxilares/etiologia , Incidência , Linfoma/epidemiologia , Mucosa Bucal/patologia , Neoplasias/classificaçãoRESUMO
Introducción: El carcinoma basocelular (CBC) corresponde a la neoplasia maligna más común en la población humana. Sus tasas de incidencia están aumentando en todo el mundo. Objetivo: El propósito de esta investigación fue analizar la localización anatómica del CBC facial y cuero cabelludo, por sexo y agresividad histológica. Metodología: Se analizaron 1732 casos de CBC (958 mujeres, 774 hombres), provenientes de 4 hospitales públicos de Santiago, Chile, durante los años 2005-2009. Las localizaciones analizadas fueron: cuero cabelludo, la frente, los párpados, la zona del ojo, las orejas, la mejilla izquierda, mejilla derecha, región medio facial y el mentón. Los subtipos histológicos Micronodular, Morfeiforme y Metatípico fueron clasificados como histológicamente agresivos, mientras que los tipos histológicos Sólido, Queratótico, Quístico, Adenoideo y Superficial se clasificaron como histológicamente no agresivos. El análisis estadístico se realizó mediante la prueba de Chi cuadrado. Resultados: Se observó una mayor frecuencia de CBC en la región medio facial (42,8 por ciento) seguida de la frente (11,3 por ciento), el párpado (10 por ciento), las orejas (7,5 por ciento), el cuero cabelludo (4,21 por ciento) y el mentón (1,85 por ciento). Discusión: Estos resultados están de acuerdo en su gran mayoría con los obtenidos en publicaciones internacionales. La distribución del CBC en cara está relacionada directamente con el grado de exposición a la radiación ultravioleta de cada sitio anatómico. En cuanto al género, la frecuencia de CBC fue mayor en mujeres que en hombres en todos los lugares anatómicos en el rostro. En el cuero cabelludo, los hombres mostraron una mayor proporción de CBC. En cuanto a la agresividad de los tumores, no hubo diferencias significativas en los lugares observados. Además, los histológicamente no agresivos fueron mayores en frecuencia en todas las localizaciones dentro de la cabeza...
Introduction: Basal cell carcinoma (BCC) of the skin is now the most common malignancy in the human population. Its incidence rates are increasing worldwide. Objective: The purpose of this research was to analyze the anatomical location of facial and scalp BCC, per gender and histological aggressiveness. Methodology: A total of 1732 (958 females, 774 males), BCC from 4 state hospitals from Santiago, Chile (2005-2009) was studied. The analyzed subsides were: scalp, forehead, eyelid, eye zone, ears, left cheek, right cheek, middle face and chin. Micronodular, Morpheiform and Metatipical histological subtypes were classified as aggressive and Superficial, Keratotic, Adenoid, Nodular were classified as non-aggressive histological subtypes. The statistical analysis was performed by the Chi square test. Results: We observed a highest frequency of BCC in middle face (42.8 percent) followed by forehead (11.3 percent), eyelid (10 percent), ears (7.5 percent), scalp (4.21 percent) and chin (1.85 percent). Discussion: These results are mainly in agreement with those obtained in other populations reported in the international literature; the BCC distribution in the head is related to ultraviolet radiation exposure of each anatomical site. Regarding the gender, the frequency of BCC was higher in females than in males in all anatomical locations within the face. In the scalp, males showed a higher proportion of BCC. Regarding the aggressitivity of the tumours, no differences within the locations were observed. Also, non-aggressive histological tumors were higher in frequency in all locations within the head. This investigation helps to identify the possible risk zones of BCC within the face and scalp in the Chilean population.
Assuntos
Humanos , Masculino , Adolescente , Adulto , Feminino , Adulto Jovem , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Carcinoma Basocelular/epidemiologia , Carcinoma Basocelular/patologia , Neoplasias de Cabeça e Pescoço/epidemiologia , Neoplasias de Cabeça e Pescoço/patologia , Chile , Hospitais Públicos/estatística & dados numéricos , Invasividade Neoplásica , Neoplasias Faciais/epidemiologia , Neoplasias Faciais/patologia , Distribuição por SexoRESUMO
The aim of the study was to determine the distribution of histologically diagnosed nonodontogenic cysts (nOCs) over a 40-year period in a Brazilian population. Biopsy records from patients with nOC from the files of the Oral Pathology Service during the period of 1970-2009 were evaluated. Among 10,311 oral biopsies, 58 met the criteria of nOCs. The most frequent nOCs were nasopalatine duct cysts (32.8%), followed by epidermoid cysts (20.7%) and oral lymphoepithelial cysts (17.2%). Nasopalatine duct cysts showed predominance among females (68.4%). Epidermoid cysts were most commonly found in the floor of the mouth (36.4%), tongue (27.3%), and buccal mucosa (27.3%). Oral lymphoepithelial cysts exhibited female prevalence (80.0%) and were commonly located in the tongue (44.4%). The frequency of nOCs found in the population studied here is slightly different from those reported in other case series. Nasopalatine duct cysts, epidermoid cysts, and oral lymphoepithelial cysts were the most common nOCs found, accounting for 70.7% of all nOCs.
Assuntos
Neoplasias Faciais/epidemiologia , Neoplasias Maxilares/epidemiologia , Neoplasias Bucais/epidemiologia , Cistos não Odontogênicos/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Biópsia , Brasil/epidemiologia , Criança , Pré-Escolar , Neoplasias Faciais/patologia , Feminino , Seguimentos , Humanos , Lactente , Masculino , Neoplasias Maxilares/patologia , Pessoa de Meia-Idade , Morbidade/tendências , Neoplasias Bucais/patologia , Cistos não Odontogênicos/patologia , Estudos Retrospectivos , Distribuição por Sexo , Taxa de Sobrevida/tendências , Fatores de Tempo , Adulto JovemRESUMO
Se realiza un estudio de las lesiones malignas de la piel facial en el Servicio de Cirugía Maxilofacial del Hospital Manuel Ascunce Domenech de Camagüey en los años 2000 y 2001. La información se obtuvo de 148 historias clínicas con el diagnóstico de lesiones malignas de la piel, de las cuales 42 correspondieron a lesiones de localización facial. La entidad que nos ocupa fue mayor en pacientes mayores de 50 años de edad, blancos, masculinos, con predominio en el tercio medio facial. Los principales tipos histológicos fueron: el carcinoma basocelular y el espinocelular, pero con mayor predominio en el primero. Se revisa el tema y se comparan nuestros resultados con los de otros autores(AU)
A study of the malignant lesions of the facial skin treated at the Maxillofacial Surgery Service of "Manuel Ascunce Domenech" Hospital, in Camagüiey, from 2000 to 2001, was conducted. The information was obtained from 148 medical histories with the diagnosis of malignant skin lesions, of which 42 corresponded to lesions of facial localization. This entity mostly affected white, male patients over 50 with predominance in the facial medial third. The main histological types were the basal cell carcinoma and the spinocellular carcinoma, with predominance of the first. The topic was reviewed and our results were compared with those of other authors(AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Neoplasias Cutâneas/epidemiologia , Neoplasias Faciais/epidemiologia , Prontuários MédicosRESUMO
Se realiza un estudio comparativo de las biopsias procesadas y diagnosticadas en la Universidad del Bajío, Escuela de Odontología, durante 1992, contrastando estos datos con un período más largo, 90-92. Se observó que existe una mayor cantidad de pacientes del sexo femenino, en relación a la edad, predominaron los pacientes entre la segunda y la tercera década de la vida. Se obtienen lesiones originadas básicamente en los tejidos epiteliales, siendo las lesiones infecciosas, reactivas y traumáticas las más frecuentes. Las lesiones malignas ocuparon el 2.34 por ciento de toda la muestra y de éstas, el 1.08 por ciento correspondieron a los carcinomas epidermoides. El nevo intradérmico, fue por mucho la lesión extraoral más frecuente. Para las lesiones, las de origen dental son las que prevalecen. Los granulomas y quistes periapicales representan el 10.5 por ciento y el 5.09 por ciento respectivamente, en toda la muestra. El quiste dentígero también quedó dentro de las lesiones más frecuentes. Se resalta la importancia de llevar el seguimiento de estos estudios, con el propósito de adecuar la docencia al servicio, se reafirma la propuesta de crear centros universitarios regionales en patología bucal, para lograr este propósito
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Neoplasias Bucais/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Estudos Transversais , Neoplasias Faciais/epidemiologia , Neoplasias de Cabeça e Pescoço/epidemiologia , Serviços de Integração Docente-Assistencial , México , Granuloma Periapical/epidemiologia , Cisto Dentígero/epidemiologia , Neoplasias das Glândulas Salivares/epidemiologiaRESUMO
A descriptive analysis was performed of the Tumor Registry data for malignant melanoma in Hispanics ascertained by the Jackson Memorial Hospital (JMH), University of Miami School of Medicine Tumor Registry. A total of 54 cases of melanoma in Hispanics was collected and reviewed. Most of the lesions of melanoma occurred on the trunk, arm, shoulder, leg, and hip. Seventy percent of the Hispanics presented with local stage disease; 26% presented with both regional and distant disease. Local stage had the best 5-year survival (87%). In regional and distant disease combined, the survival was better for Hispanics than non-Hispanics (p = 0.01). In addition, it was found that the Hispanics in the over 50-year-old age group did better than the non-Hispanics in the same group (p = 0.05). Comparison of survival between Hispanic males and females shows that Hispanic females have a 5-year survival of 86% compared to 56% for Hispanic males (p = 0.017).
Assuntos
Hispânico ou Latino , Melanoma/etnologia , Melanoma/epidemiologia , Neoplasias Cutâneas/etnologia , Neoplasias Cutâneas/epidemiologia , Abdome , Adolescente , Adulto , Idoso , América Central/etnologia , Criança , Cuba/etnologia , Extremidades , Neoplasias Faciais/epidemiologia , Neoplasias Faciais/etnologia , Feminino , Florida/epidemiologia , Neoplasias de Cabeça e Pescoço/epidemiologia , Neoplasias de Cabeça e Pescoço/etnologia , Humanos , Tábuas de Vida , Masculino , Melanoma/patologia , Pessoa de Meia-Idade , Metástase Neoplásica , Estadiamento de Neoplasias , Sistema de Registros , Estudos Retrospectivos , Neoplasias Cutâneas/patologia , América do Sul/etnologia , Taxa de Sobrevida , TóraxRESUMO
Se efectuó un estudio descriptivo, longitudinal y prospectivo de 185 pacientes con tumores cutáneos de diversos tipos, atendidos durante el trienio 1988-1990 en el Hospital Clinicoquirúrgico Obstétrico "Celia Sánchez Manduley" de Manzanillo. Se describe la epidemiología, así como los caracteres físicos y procedimientos diagnósticos y terapéuticos empleados. Además se pone de manifiesto la necesidad de realizar una campaña de precención de las neoplasias cutáneas y de crear unidades oncológicas cutáneas multidisciplinarias para el logro de resultados integrales, tales como: curabilidad total, estética conservada y la no existencia de trastornos funcionales de importancia en estos pacientes