RESUMO
Pain and anxiety are common symptoms in head and neck cancer patients. The anticonvulsant pregabalin has therapeutic indication for the treatment of pain and anxiety, and may represent a useful drug for both conditions. Thus, the aim of this study was to investigate the relationship between pain and anxiety in rats with facial carcinoma, as the influence of pregabalin treatment in both aspects. Facial carcinoma was induced by subcutaneous inoculation of Walker-256 tumor cells in the vibrissa pad of Wistar rats. On day 6 after inoculation spontaneous facial grooming and conditioned place preference were assessed as non-evoked pain measurements and facial mechanical hyperalgesia were assessed 3 and 6 days after tumor cells inoculation. Moreover, anxiety-like behavior was evaluated on the elevated plus maze and light-dark transition tests at the same time points. The effect of pregabalin treatment (30 mg/kg, p.o.) was evaluated in all tests. Our results demonstrated that pregabalin treatment reduced the spontaneous facial grooming and induced conditioned place preference 6 days post tumor inoculation. Tumor-bearing rats developed mechanical hyperalgesia starting 3 days post tumor induction, which was also significant on day 6, but the anxiety-like behavior was detected only in tumor-bearing rats that developed mechanical hyperalgesia and only six days after tumor cells inoculation. Both, the mechanical hyperalgesia and the anxiety-like behavior related to the tumor were significantly reduced by pregabalin treatment on day 6. Pregabalin treatment resulted in antinociceptive and anxiolytic-like effects on facial tumor-bearing rats and may represent a promising therapeutic option for cancer patients.
Assuntos
Analgésicos/farmacologia , Ansiolíticos/farmacologia , Ansiedade/tratamento farmacológico , Neoplasias Faciais/tratamento farmacológico , Dor Facial/tratamento farmacológico , Pregabalina/farmacologia , Animais , Ansiedade/fisiopatologia , Dor do Câncer/tratamento farmacológico , Dor do Câncer/fisiopatologia , Linhagem Celular Tumoral , Condicionamento Psicológico/efeitos dos fármacos , Neoplasias Faciais/fisiopatologia , Neoplasias Faciais/psicologia , Dor Facial/fisiopatologia , Asseio Animal/efeitos dos fármacos , Hiperalgesia/tratamento farmacológico , Hiperalgesia/fisiopatologia , Masculino , Transplante de Neoplasias , Dor Nociceptiva/tratamento farmacológico , Dor Nociceptiva/fisiopatologia , Ratos Wistar , Comportamento Espacial/efeitos dos fármacos , Tato , VibrissasRESUMO
Pain and anxiety are commonly experienced by cancer patients and both significantly impair their quality of life. Some authors claim that there is a relationship between pain and anxiety, while others suggest that there is not a direct association. In any case, there is indeed a consensus that anxiety impairs the pain condition beyond be under diagnosed and undertreated in cancer pain patients. Herein we investigated if rats presenting heat hyperalgesia induced by orofacial cancer cell inoculation would display anxiety-like behaviors. In addition, we evaluated if pain blockade would result in alleviation of anxiety behaviors, as well as, if blockade of anxiety would result in pain relief. Orofacial cancer was induced in male Wistar rats by inoculation of Walker-256 cells into the right vibrissal pad. Heat facial hyperalgesia was assessed on day 6 after the inoculation, and on this time point rats were submitted to the elevated plus maze and the light-dark transition tests. The influence of lidocaine and midazolam on heat hyperalgesia and anxiety-like behaviors was assessed. The peak of facial heat hyperalgesia was detected 6 days after cancer cells inoculation, and at this time point, rats exhibited increased anxiety-like behaviors. Local treatment with lidocaine (2%/50µL) caused a marked reduction of heat hyperalgesia, but failed to affect the anxiety-like behaviors, while midazolam (0.5mg/kg, i.p.) treatment failed to change the heat threshold, but induced an anxiolytic-like effect. Altogether, our data demonstrated that rats with orofacial cancer present pain- and anxiety-like behaviors, but brief heat hyperalgesia relief does not affect the anxiety-like behaviors, and vice-versa, in our experimental conditions.
Assuntos
Ansiedade/tratamento farmacológico , Neoplasias Faciais/fisiopatologia , Neoplasias Faciais/psicologia , Hiperalgesia/tratamento farmacológico , Neoplasias Bucais/fisiopatologia , Neoplasias Bucais/psicologia , Analgésicos/uso terapêutico , Animais , Ansiolíticos/uso terapêutico , Ansiedade/psicologia , Linhagem Celular Tumoral , Temperatura Alta , Hiperalgesia/fisiopatologia , Hiperalgesia/psicologia , Lidocaína/uso terapêutico , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Midazolam/uso terapêutico , Transplante de Neoplasias , Ratos Wistar , Limiar SensorialRESUMO
Os autores apresentam o caso de um paciente com lesåo tumoral de aproximadamente 22 cm de diâmetro, vegetante, hemorrágica, irregular, acometendo toda hemiface e hemicrânio esquerdos. O paciente foi submetido a exérese ampla da lesåo e o exame anatomopatológico revelou carcinoma espinocelular bem diferenciado. Apesar do tamanho da lesåo nåo havia metástases
Assuntos
Humanos , Masculino , Idoso , Carcinoma de Células Escamosas/cirurgia , Neoplasias Faciais/fisiopatologia , Neoplasias Faciais/cirurgiaRESUMO
Se presenta el caso de un paciente del sexo masculino de 44 años de edad quien presentó un carcinoma adenoideo quístico de glándula salival accesoria de la mejilla y que se extendió en forma destructiva afectando la mitad derecha de la cara incluyendo los tejidos blandos orbitarios. El paciente fue tratado con cirugía radical y recubrimiento con colgajo musculocutáneo pectoral el cual presentó hematoma y se substituyó por un colgajo musculocutáneo del dorsal ancho.