RESUMO
Sialadenoma papilliferum (SP) is a rare benign tumour of salivary gland origin, which has been included among the ductal papillomas in the latest classification of tumours by the World Health Organisation. Two SP from the minor salivary gland of the palate of middle age patients were presented and studied by immunohistochemical. Our results showed presence of cytokeratins (CKs) 13, 14, 7, 8, 19 and absence of vimentin and smooth muscle actin. This immunoprofile is similar to the excretory duct of salivary gland.
Assuntos
Adenoma/química , Neoplasias das Glândulas Salivares/química , Glândulas Salivares Menores/química , Feminino , Humanos , Imuno-Histoquímica , Queratinas/análise , Masculino , Pessoa de Meia-Idade , Neoplasias Palatinas/química , Palato Duro/química , Palato Mole/químicaRESUMO
Follicular dendritic cell tumors are uncommon and usually occur in lymph nodes. We report the case of a follicular dendritic cell tumor that occurred in the palate of a 14-year-old boy and manifested itself as a nodular mass. Histologically, the neoplasm consisted of spindle-shaped or oval-shaped cells with eosinophilic cytoplasms and nuclei with delicate, dispersed chromatin. The lesional cells were principally arranged in diffuse, fascicular patterns with vaguely whorled or storiform areas. Focal multinucleate tumor giant cells and lymphocytes were observed throughout the neoplasm. Immunohistochemically, tumor cells were positive for the follicular dendritic cell markers CD21, CD35, and CD23 and for S-100 protein, CD68, and muscle-specific actin. Tumor cells were negative for LCA, CD20, EMA, CK (AE1/AE3), HMB45, and CD34. Lymphocytes were positive for LCA and CD45RO. Although follicular dendritic cell sarcoma is a very uncommon tumor, it should be included in the differential diagnosis of tumors in this location.
Assuntos
Células Dendríticas/patologia , Neoplasias Palatinas/patologia , Sarcoma/patologia , Adolescente , Antígenos de Neoplasias/análise , Biomarcadores Tumorais , Células Dendríticas/química , Humanos , Imuno-Histoquímica , Masculino , Neoplasias Palatinas/química , Sarcoma/químicaRESUMO
An apparent relationship between breast cancer and salivary gland cancer has been observed, and there is one report in the literature that describes estrogen receptors in normal salivary gland and salivary gland cancers. With the use of a monoclonal antibody against estrogen receptor protein and the avidin-biotin immunoperoxidase procedure, we were unable to demonstrate estrogen receptors in formalin-fixed paraffin-embedded sections of either polymorphous low-grade adenocarcinoma or adenoid cystic carcinoma of salivary gland origin.
Assuntos
Adenocarcinoma/química , Carcinoma Adenoide Cístico/química , Carcinoma Ductal de Mama/química , Carcinoma Lobular/química , Receptores de Estrogênio/análise , Neoplasias das Glândulas Salivares/química , Glândulas Salivares Menores/química , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/química , Neoplasias Palatinas/químicaRESUMO
The histopathologic and immunohistochemical features of the myoepithelioma are presented. Antibodies used were: keratin, vimentin, and S-100 protein. Vimentin proved to be the ideal marker for myoepithelial cells being present in the different morphological types exhibited by the cell.