RESUMO
PURPOSE:: To evaluate the effects of L-lysine on the intestinal and urothelial epithelium of rats subjected to ureterosigmoidostomy (new model for surgical carcinogenesis). METHODS:: Forty-two rats, 9 weeks of age, were divided into 6 groups. Animals in groups A, B, C were subjected to ureterosigmoidostomy (US) and treated with L-lysine, celecoxib and H2O, respectively. Groups D, E and F (non-operated controls) received L-lysine, celecoxib and H2O, respectively. The L-lysine dose was 150 mg/kg and that of celecoxib was 20 mg/kg. The colon was analyzed for the presence of aberrant crypt foci (ACF) under a stereomicroscope.The tissue was stained with hematoxylin and eosin and PAS alcian blue. RESULTS:: There were rare ACF, and there was no statistically significant difference between the groups. Histopathologic study of the ureteral epithelium identified moderate to severe urothelial hyperplasia in rats with ureterosigmoidostomy. Transitional hyperplasia in the ureters of animals receiving L-lysine (A) showed an apparent difference compared to the control (C) (P=0.2424). There was no dysplasia or atypia. CONCLUSION:: L-lysine does not promote carcinogenesis of the intestinal and urethelial epithelium of rats subjected to ureterosigmoidostomy at the doses and times studied.
Assuntos
Focos de Criptas Aberrantes/patologia , Carcinogênese , Colo Sigmoide/cirurgia , Neoplasias Intestinais/etiologia , Lisina/farmacologia , Estomas Cirúrgicos , Ureterostomia/efeitos adversos , Derivação Urinária , Neoplasias Urológicas/etiologia , Animais , Modelos Animais de Doenças , Feminino , Mucosa Intestinal/patologia , Ratos , Ratos Wistar , Estomas Cirúrgicos/efeitos adversos , Ureterostomia/métodos , Neoplasias da Bexiga Urinária/etiologiaRESUMO
Epidemiological and laboratory research has shown that dietary components are associated with the risk of developing urinary tract tumors (UTT). The purpose of this case-control study, carried out between 2004 and 2008 in Córdoba, a Mediterranean city in Argentina, was to describe the role of dietary patterns and to investigate any association with the risk of developing UTT. One hundred and sixty-eight patients with histologically confirmed transitional UTT and 334 controls with acute, nonneoplastic, and nonurinary tract diseases from the same hospitals were studied. All patients were interviewed about their food habits and their exposure to a number of known or suspected risk factors for UTT. Multiple correspondence analysis was used to explore dietary patterns and data analyses were carried out by calculating odds ratios and their 95% confidence intervals by using multiple logistic regression. Two main dietary patterns identified were a 'prudent' pattern that was linked to controls and a 'western' pattern that was associated with cases. A frequent intake of vegetable oils, lean meats, grains, and fruits, the moderate use of alcohol (mainly red wine) together with potato and sweet consumption, and the habit of taking at least four meals per day, were associated with a reduced risk for UTT. In contrast, frequent consumption of infusions (mainly maté), potatoes, alcohol, sweets, and processed meat resulted in a high risk for UTT. The dietary patterns of our population have a role in the development of UTT, thus implying that appropriate nutritional education may decrease this risk.
Assuntos
Carcinoma de Células de Transição/epidemiologia , Dieta/estatística & dados numéricos , Comportamento Alimentar , Neoplasias Urológicas/epidemiologia , Idoso , Argentina/epidemiologia , Carcinoma de Células de Transição/etiologia , Carcinoma de Células de Transição/prevenção & controle , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Neoplasias Urológicas/etiologia , Neoplasias Urológicas/prevenção & controleRESUMO
A considerable amount of experimental, clinical and epidemiological data indicate that dietary fats play a role in urinary tract tumorigenesis. In rodents, chronic essential fatty acid (EFA) deficiency seems to induce both urolithiasis and transitional hyperplasias, followed by a tendency for tumorigenesis of the urinary passages. High intake of saturated fats or non-EFAs, conditions that may induce EFA deficiency (EFAD) increase the risk of bladder cancer in case-control studies. In other cell populations, EFAs are beneficial as preventive and therapeutic nutrients for the treatment of cancer. Thus, it is reasonable to assume that abnormal metabolism and/or nutritional deprivation of EFA, by inducing a chronic or a subclinical EFA deficiency, may enhance the risk of urothelial tumorigenesis.
Assuntos
Ácidos Graxos Essenciais/deficiência , Neoplasias Urológicas/etiologia , Epitélio/patologia , Humanos , Fenômenos Fisiológicos da Nutrição , Fatores de Risco , Neoplasias da Bexiga Urinária/epidemiologia , Neoplasias da Bexiga Urinária/etiologia , Neoplasias da Bexiga Urinária/patologia , Neoplasias Urológicas/epidemiologia , Neoplasias Urológicas/patologiaRESUMO
Cancer of the uterine cervix has been related to HPV infection, based on clinical and laboratory data. The high recurrence rate in couples undergoing treatment for HPV infection points to a probable viral reservoir, either in subclinical lesions or in male internal genital organs. We have evaluated 31 men, all sexual partners of women with HPV infection. Eleven patients (35.5%) had related lesions: 4 (12.9%) with condyloma acuminatum; 5(16.1%) with lesions revealed by magnified examination after reaction with 5% acetic acid and 2(6.5%) with condyloma and subclinical lesions. A short-term follow-up confirmed a successful treatment with podophyllin