Assuntos
Carcinoma de Células Escamosas , Neoplasias Labiais , Neoplasias Orofaríngeas , Humanos , Prognóstico , Lábio/patologia , Orofaringe/patologia , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Neoplasias Orofaríngeas/patologia , Neoplasias Labiais/patologiaRESUMO
Diffuse large B cell lymphoma, not otherwise specified (DLBCL, NOS) is the most frequent non-Hodgkin lymphoma subtype. This aggressive neoplasm may variably express the CD30 protein, which may be used as a therapeutic target for this tumor. However, CD30 expression in DLBCL NOS arising from the oral cavity and the oropharynx has not been investigated. Therefore, this study aims to determine the frequency of CD30 expression and its prognostic significance for patients affected by oral/oropharyngeal DLBCL NOS. Fifty cases were retrieved from pathology files and submitted to immunohistochemistry against CD30. Reactivity was accessed by two oral pathologists using two cut-off values (> 0% and > 20% of tumor cells) to determine positivity in each case. Clinical data were obtained from the patients' medical files to investigate the prognostic potential of the protein. Seven high-grade B cell lymphomas and two EBV-positive DLBCL NOS were identified. We found one CD30-positive case in each of these two groups of lymphomas. Among the remaining 41 DLBCL NOS, other four cases (three in the oral cavity and one in the oropharynx) were positive for CD30, but only two expressed the protein in > 20% of tumor cells, both in the oral cavity. Survival analysis demonstrated that CD30-positive cases had a higher five-year overall survival rate (75%) than CD30-negative cases (32.3%), although a statistically significant result was not achieved (p = 0.19). Only a minor subset of oral and oropharyngeal DLBCL NOS express CD30 and these patients seems to have a higher survival rate.
Assuntos
Antígeno Ki-1 , Linfoma Difuso de Grandes Células B , Humanos , Imuno-Histoquímica , Antígeno Ki-1/análise , Antígeno Ki-1/uso terapêutico , Linfoma Difuso de Grandes Células B/patologia , Orofaringe/química , Orofaringe/patologia , PrognósticoRESUMO
BACKGROUND: Oropharyngeal cancer is an important public health problem. The aim of our study was to correlatep16 immunohistochemistry in oropharynx squamous cell carcinomas(OPSCC) with clinical and epidemiological features. MATERIAL AND METHODS: We conducted across-sectional study on patients with OPSCC treated at a single institution from 2014 to 2019. Epidemiological and clinical-pathological data were collected from medical records and a questionnaire was applied to determine alcohol consumption, smoking, and sexual behavior. The HPV status was determined by p16 immunohistochemistry. RESULTS: A total of 252 patients participated in the study, of these 221 (87.7%) were male. There were 81 (32.14%) p16 positive cases and 171 (67.85%) p16 negative cases. The p16positive group was significantly associated with younger patients (50-59 years), higher education level, lower clinical stage and patients who never drank or smoked. Through univariate logistic regression, we observed that female sex (OR, 3.47; 95% CI, 1.60-7.51) and higher education level (OR, 9.39; 95% CI, 2, 81-31,38) were significantly more likely to be p16 positive. Early clinical stage (AJCC8ed) was more associated with p16 positivity both in univariate (OR, 0.14; 95% CI, 0.07-0.26, p<0.001) and multivariate analysis (OR, 0.18; 95% CI, 0.06-0.49, p = 0.001). CONCLUSION: This study showed that drinkers and current smokers were less likely to be p16+. Female sex, higher education level and younger age at diagnosis were associated with a higher probability of being p16+. Additionally, there was a higher proportion of patients with early clinical stage (I or II) in the p16 positive group when compared to the p16 negative group.
Assuntos
Inibidor p16 de Quinase Dependente de Ciclina/metabolismo , Neoplasias Orofaríngeas/metabolismo , Orofaringe/metabolismo , Carcinoma de Células Escamosas de Cabeça e Pescoço/metabolismo , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Consumo de Bebidas Alcoólicas , Estudos Transversais , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias Orofaríngeas/epidemiologia , Neoplasias Orofaríngeas/patologia , Orofaringe/patologia , Fatores de Risco , Fatores Sexuais , Comportamento Sexual , Fumar , Carcinoma de Células Escamosas de Cabeça e Pescoço/epidemiologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Adulto JovemRESUMO
O tabaco e o álcool são os principais fatores etiológicos do carcinoma de células escamosas de orofaringe (CCEO), no entanto, nos últimos anos, o papiloma vírus humano (HPV) de alto risco vem sendo reconhecido como a principal causa do aumento da incidência desta doença em várias partes do mundo. No Brasil, a situação epidemiológica do CCEO relacionado ao HPV ainda é pouco explorada. O objetivo do presente estudo foi avaliar as características clinicopatológicas do carcinoma de células escamosas de orofaringe (CCEO) em uma população do Rio de Janeiro. Cento e cinquenta e dois casos diagnosticados como CCEO primário no Laboratório de Patologia Oral da Faculdade de Odontologia da UFRJ entre 2014 e 2020 foram incluídos no estudo. Os dados clínicos foram coletados retrospectivamente das fichas do exame histopatológico e todos os casos foram classificados microscopicamente como queratinizantes, não-queratinizantes ou não-queratinizantes com áreas de maturação. Em 143 casos foi realizada a pesquisa do HPV aravés de imuno-histoquímica para p16INK4a, sendo os casos positivos submetidos à hibridização in situ de DNA (HIS) com sonda de amplo espectro. Havia 29 mulheres e 123 homens, com média de idade de 61 anos (variando de 39 a 89 anos). A maioria dos pacientes consumia regularmente tabaco (69%) e álcool (50,7%). Grande parte dos tumores media mais de 2 cm e localizava-se principalmente no palato mole (48%), seguido por orofaringe não especificada, tonsila e base da língua. Os três subtipos histológicos foram distribuídos de forma praticamente semelhante entre os casos, com 36% queratinizantes, 34% não queratinizantes e 30% não queratinizantes com áreas de maturação. Dos 143 casos testados, 20 (14%) foram positivos para p16INK4a e, destes, 19 (13,3%) foram positivos para o HPV pela hibridização para DNA, sendo a maioria tumores não-queratinizantes. A prevalência de HPV foi baixa em casos de CCEO nesta população brasileira. (AU)
Tobacco and alcohol are the main etiological factors of oropharyngeal squamous cell carcinoma (CCEO), however, in recent years, high-risk human papillomavirus (HPV) has been recognized as the main cause of the increased incidence of this disease in various parts of the world. In Brazil, the epidemiological situation of the CCEO related to HPV is still little explored. The aim of the present study was to evaluate the clinicopathological features of oropharyngeal squamous cell carcinoma (OPSCC) in a population from Rio de Janeiro-Brazil. There were 152 patients diagnosed with primary OPSCC in an Oral Pathology Laboratory between 2014 and 2020. Clinical data were retrospectively collected from the records and all cases were microscopically classified as keratinizing, nonkeratinizing or nonkeratinizing with maturation. In 143 cases, HPV status was investigated using immunohistochemistry for p16INK4a , and the positive cases were submitted to DNA in situ hybridization (HIS) with a wide spectrum probe. There were 29 women and 123 men, with a mean age of 61 years (ranging from 39 to 89 years). Most patients regularly consumed tobacco (69%) and alcohol (50.7%). Most of the tumors measured more than 2 cm and were located mainly in the soft palate (48%), followed by unspecified oropharynx, tonsil and base of the tongue. The three histological subtypes were practically similarly distributed among the cases, with 36% keratinizing, 34% nonkeratinizing and 30% nonkeratinizing with areas of maturation. Of the 143 cases tested, 20 (14%) were positive for p16 INK4a and, of these, 19 (13.3%) were positive for HPV by DNA hybridization, most non-keratinizing tumors. The prevalence of HPV was low in cases of OSCC in this Brazilian population. (AU)
Assuntos
Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Orofaringe/patologia , Papillomaviridae , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Patologia Bucal , PrevalênciaRESUMO
Mucosal leishmaniasis (ML) affects predominantly the nose and occurs usually weeks or months after the cure of the primary cutaneous lesion. The pathology of ML is characterized by an exaggerated inflammatory reaction with infiltration of lymphocytes, macrophages, and plasma cells. There is also a paucity of parasites and a strong delayed-type hypersensitivity reaction. Herein, we report a case of a young man who had a large ulcer in his left leg and complained of dysphagia. In nasofibrolaryngoscopy, there were nodular lesions in the oropharynx and rhinopharynx. The skin lesion biopsy showed a chronic inflammation with amastigotes inside macrophages, and DNA of Leishmania braziliensis confirmed the diagnosis of ML in tissue biopsied from the pharynx. The leishmaniasis skin test was negative. Cytokine evaluation showed lack of production of interferon (IFN)-γ, interleukin (IL)-1ß, and IL-17 with enhancement of these cytokine levels after cure.
Assuntos
Leishmania braziliensis/isolamento & purificação , Leishmaniose Mucocutânea , Antiprotozoários/uso terapêutico , Citocinas/efeitos dos fármacos , Citocinas/metabolismo , Transtornos de Deglutição/tratamento farmacológico , Transtornos de Deglutição/etiologia , Humanos , Leishmania braziliensis/efeitos dos fármacos , Leishmaniose Mucocutânea/diagnóstico , Leishmaniose Mucocutânea/tratamento farmacológico , Leishmaniose Mucocutânea/patologia , Macrófagos/parasitologia , Masculino , Antimoniato de Meglumina/uso terapêutico , Pessoa de Meia-Idade , Nasofaringe/parasitologia , Nasofaringe/patologia , Orofaringe/parasitologia , Orofaringe/patologia , Pele/parasitologia , Pele/patologiaAssuntos
Neoplasias Bucais/patologia , Estadiamento de Neoplasias/métodos , Neoplasias Orofaríngeas/patologia , Orofaringe/patologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Idoso , Consumo de Bebidas Alcoólicas/epidemiologia , Brasil/epidemiologia , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/mortalidade , Invasividade Neoplásica , Neoplasias Orofaríngeas/mortalidade , Neoplasias Orofaríngeas/virologia , Fumar/epidemiologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/mortalidade , Carcinoma de Células Escamosas de Cabeça e Pescoço/virologiaRESUMO
O carcinoma espinocelular (CEC) é a neoplasia maligna mais comum da boca e orofaringe, correspondendo ao quinto tipo de câncer mais comum entre os homens no Brasil, assim como na região sudeste. É considerado um problema de saúde pública, principalmente porque a maioria dos pacientes é diagnosticada em estágio avançado da doença, implicando em morbidade e mortalidade significativas. Muito embora os avanços no diagnóstico e tratamento de diversos tipos de câncer resultarem em prevenção, diagnóstico precoce e aumento de sobrevida, para o CEC de boca e orofaringe não são observadas melhorias dos indicadores epidemiológicos ao longo do tempo. O objetivo do presente trabalho foi descrever o perfil dos pacientes provenientes da Serviço Público de Saúde do município do Rio de Janeiro diagnosticados com câncer de boca e orofaringe no Laboratório de Patologia Oral da Faculdade de Odontologia da UFRJ no período de Janeiro de 2013 a Dezembro de 2019. Os seguintes dados foram coletados das fichas de requisição do exame histopatológico: sexo, idade, hábitos/ tabagismo e etilismo, tempo de evolução da lesão, localização da lesão, bairro de residência do paciente, área programática da residência do paciente e área programática da Unidade de Saúde. Um total de 438 pacientes foi incluído no estudo de acordo com os critérios estabelecidos. Em relação ao sexo, houve um predomínio do sexo masculino (74%), sendo a faixa etária mais acometida a de 60 a 69 anos (40,6%), com média de idade de 63 anos. A maioria dos pacientes era tabagista (56,4%) e 39,7% dos pacientes eram etilistas, embora esta informação estivesse ausente em muitas fichas (41,8%). O tempo de evolução da maioria das lesões foi de 1 a 3 meses (37,7%) e a língua móvel foi a localização anatômica mais frequente (34,7%), seguida da orofaringe (18,9%). O bairro de Santa Cruz apresentou o maior número de pacientes (7,1%) e a área programática de maior incidência de casos diagnosticados de CEC foi a AP 3.1 com 32,2% das biópsias sendo realizadas em unidades de saúde desta região. Os estudos epidemiológicos são de grande relevância para que se possa estimar a magnitude do problema em uma determinada região e caracterizar o perfil dos pacientes acometidos. Os resultados do presente trabalho poderem contribuir para a elaboração de políticas de saúde mais intensas direcionadas aos grupos mais afetados e às áreas de maior frequência da doença na cidade do Rio de Janeiro. (AU)
Squamous cell carcinoma (SCC) is the most commom malignant neoplasm of the mouth and oropharynx, corresponding to the fifth most common type of cancer among men in Brazil, as well as in the southeast region. It is considered a public health problem, mainly because most patients are diagnosed at an advanced stage of the disease, resulting in significant morbidity and mortality. Although advances in the diagnosis and treatment of several types of cancer result in prevention, early diagnosis and increased survival, for SCC of the mouth there are no improvements in epidemiological indicators over time. The aim of this study was to describe the profile of the patients from the Public Health Network of the Rio de Janeiro diagnosed with oral cancer at the Pathology Laboratory of the Faculty of Dentistry at UFRJ in the period from January 2013 to December 2019. The following data were collected from the request forms for the histopathological examination: sex, age, habits/ smoking and drinking, time of the evolution of the lesion, location of the lesion, neighborhood of the patient's residence, programmatic area of the patient's residence and programmatic area of the Health Unit. A total of 438 patients were found according to the established inclusion criteria. Regarding gender, there was a predominance of males (74%), the most affected age group was 60 to 69 years (40,6%), most patients were smokers (56,4%) and 39,7% of the patients were alcoholic, although most of the forms did not provide this information (41,8%). The time for the evolution of most injuries was 1 to 3 months (37,7%), the mobile tongue was the most frequent anatomical location (34,7%), followed by the oropharynx (18,9%), the neighborhood of Santa Cruz showed the highest number of cases (7,1%) and programmatic area of greatest incidence for the diagnosis of SCC was AP 3.1 with 32,2% of the biopsies being performed in health units in this region. Epidemiological studies are of great relevance in order to estimate the magnitude of the problem in given region and to characterize the profile of affected patients. The results of this study can contribute to the development of more intense health policies aimed at the most affected groups and areas of higher frequency of the disease in the city of Rio de Janeiro. (AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Orofaringe/patologia , Tabagismo/complicações , Neoplasias Bucais/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Estudos Epidemiológicos , Prontuários Médicos , Saúde Pública , Distribuição por Idade e SexoRESUMO
RESUMEN La estenosis faríngea es una complicación muy poco frecuente de la adenoamigdalectomía. Consiste en un estrechamiento de la vía aerodigestiva superior secundaria a la adhesión parcial o total de las estructuras que componen la orofaringe producto de una disección extensa al realizar amigdalectomía. El objetivo de este trabajo es presentar tres casos clínicos tratamiento y correspondiente técnica quirúrgica. Se describen tres pacientes operados durante la edad preescolar de adenoamigdalectomía, que cursaron en el posoperatorio con estenosis faríngea. Todos presentaron roncopatía severa, respiración oral y resonancia hiponasal. La nasofibroscopía evidenció estrechez faríngea en distintos grados. A todos se les realizó resección del tejido cicatricial y faringoplastía con colgajo miomucoso y posterior rehabilitación con bulbo faríngeo. El uso de colgajos faríngeos posterior a la liberación de adherencias posadenoamigdalectomía permite aportar tejido sano a zonas cruentas, evitando la formación de nuevas adherencias y restituyendo la permeabilidad oronasal. El bulbo faríngeo es fundamental para mantener un apropiado lumen y manejo de la cicatrización en el posoperatorio. La técnica de colgajo faríngeo lateral, que interpone mucosa faríngea sana para la cobertura del lecho cruento, constituye una alternativa quirúrgica eficaz para resolver la estenosis faríngea posquirúrgica.
ABSTRACT Pharyngeal stenosis is a very rare complication of adenotonsillectomy. It is caused by a narrowing of the upper aerodigestive pathway secondary to the total or partial adhesion of the retropharyngeal structures as a result of extensive dissection during tonsillectomy. Our aim is to present three consecutive clinical cases of pharyngeal stenosis after adenotonsillectomy, discuss its treatment and corresponding surgical technique. We present three infants with adenotonsillectomy with postoperative pharyngeal stenosis. All had severe snoring, oral breathing and hyponasal resonance. The nasofibroscopy showed pharyngeal obliteration in several degrees. All patients underwent scar tissue resection and pharyngoplasty with myomucosal flap and subsequent use of pharyngeal bulb. The use of pharyngeal flaps after release of pharyngeal adhesions allows to provide healthy tissue to row areas, avoiding new postoperative adhesions and providing adequate oronasal permeability. The pharyngeal bulb is essential to maintain permeability and management of scarring in the postoperative period. The technique of lateral pharyngeal flap, which aims to interpose healthy pharyngeal mucosa to cover the bloody bed, is an effective therapeutic alternative to solve post-surgical pharyngeal stenosis.
Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/patologia , Adenoidectomia/efeitos adversos , Orofaringe/patologia , Complicações Pós-Operatórias/cirurgia , Constrição PatológicaRESUMO
Resumen Introducción: La mucositis orofaríngea (MO) es una de las principales complicaciones del tratamiento oncológico que reduce significativamente la calidad de vida (CV) del paciente. El objetivo fue traducir, adaptar de manera cultural y validar una nueva versión en español del instrumento Oropharyngeal Mucositis-Specific Quality-of-Life (OMQoL) en pacientes pediátricos. Métodos: Estudio transversal de validación, multicéntrico, realizado para la traducción y adaptación del OMQoL del inglés al español en pacientes de entre 8 y 16 años con MO. Se midió la confiabilidad mediante el Alfa de Cronbach; la validez del contenido y el constructo, con un análisis factorial exploratorio; y la validez convergente, con las correlaciones de las escalas para MO de la Organización Mundial de la Salud (OMS), la Oropharingeal Mucositis Assessment Scale (OMAS) y con el Pediatric Quality of Life-3 (PedsQL-3) módulo cáncer en español. Resultados: Participaron en el estudio 193 niños con una media de edad de 10.91 ± 2.38 años, de los cuales 101 (52.3%) fueron de sexo femenino. En esta muestra, 80 niños (41.5%) presentaron leucemia aguda linfoblástica y 111 (57.5%) presentaron MO grado 2 y 3. El análisis factorial resultó con cuatro dimensiones con cargas > 0.40. De los 31 ítems del OMQoL, seis fueron eliminados. El Alfa de Cronbach del OMQoL español fue de 0.954. Las correlaciones de Spearman (r) con las escalas de la OMS y OMAS fueron significativas (r = −0.720 y r = −0.689; p<0.01, respectivamente); con el PedsQL-3 módulo cáncer existió una moderada correlación (r = 0.426; p < 0.01). Conclusiones: La nueva versión del OMQoL en español demostró propiedades psicométricas adecuadas, y resulta un instrumento confiable y válido para medir la CV en niños con MO.
Abstract Background: Oropharyngeal mucositis (OM) is one of the primary complications arising during oncological treatment, which significantly reduces the patient's quality of life (QoL). The aim of this study was to translate, culturally adapt, and validate the use of a new Spanish version of the Oropharyngeal Mucositis-Specific Quality-of-Life instrument (OMQoL) for pediatric patients. Methods: A multicentric, cross-sectional validation study was conducted to translate and adapt OMQoL from English to Spanish for its use by children with OM aged 8-16 years. Reliability was measured using Cronbach's alpha; content and construct validity, in conjunction with exploratory factor analysis. The convergent validity, with the correlations of the scales for OM defined by the WHO, OMAS (Oropharingeal Mucositis Assessment Scale) and the PedsQL-3 cancer module in Spanish. Results: One hundred and ninety-three children with mean age of 10.91 ± 2.38 years participated in the study, out of which 101 (52.3%) were females. In this sample, 80 children (41.5%) suffered from acute lymphoblastic leukemia and 111 (57.5%) had grade 2 and 3 OM. The factorial analysis resulted in four dimensions with loads >0.40. Among the 31 items of the OMQoL, six were eliminated. Cronbach alpha of OMQoL-Spanish was 0.954. Spearman´s correlations (r) with the OMS and OMAS scales were significant (with r = −0.720 and r = −0.689; p < 0.01, respectively). Moderate correlation was observed with the PedsQL-3 cancer module (r = 0.426; p < 0.01). Conclusions: OMQoL-Spanish demonstrated adequate psychometric properties, resulting in a reliable and valid instrument for measuring QoL in children with MO.
Assuntos
Adolescente , Criança , Humanos , Masculino , Qualidade de Vida , Doenças Faríngeas/patologia , Mucosite/patologia , Neoplasias/terapia , Orofaringe/patologia , Psicometria , Doenças Faríngeas/etiologia , Estudos Transversais , Reprodutibilidade dos Testes , Mucosite/etiologiaRESUMO
Background: Oropharyngeal mucositis (OM) is one of the primary complications arising during oncological treatment, which significantly reduces the patient's quality of life (QoL). The aim of this study was to translate, culturally adapt, and validate the use of a new Spanish version of the Oropharyngeal Mucositis-Specific Quality-of-Life instrument (OMQoL) for pediatric patients. Methods: A multicentric, cross-sectional validation study was conducted to translate and adapt OMQoL from English to Spanish for its use by children with OM aged 8-16 years. Reliability was measured using Cronbach's alpha; content and construct validity, in conjunction with exploratory factor analysis. The convergent validity, with the correlations of the scales for OM defined by the WHO, OMAS (Oropharingeal Mucositis Assessment Scale) and the PedsQL-3 cancer module in Spanish. Results: One hundred and ninety-three children with mean age of 10.91 ± 2.38 years participated in the study, out of which 101 (52.3%) were females. In this sample, 80 children (41.5%) suffered from acute lymphoblastic leukemia and 111 (57.5%) had grade 2 and 3 OM. The factorial analysis resulted in four dimensions with loads >0.40. Among the 31 items of the OMQoL, six were eliminated. Cronbach alpha of OMQoL-Spanish was 0.954. Spearman´s correlations (r) with the OMS and OMAS scales were significant (with r = -0.720 and r = -0.689; p < 0.01, respectively). Moderate correlation was observed with the PedsQL-3 cancer module (r = 0.426; p < 0.01). Conclusions: OMQoL-Spanish demonstrated adequate psychometric properties, resulting in a reliable and valid instrument for measuring QoL in children with MO.
Introducción: La mucositis orofaríngea (MO) es una de las principales complicaciones del tratamiento oncológico que reduce significativamente la calidad de vida (CV) del paciente. El objetivo fue traducir, adaptar de manera cultural y validar una nueva versión en español del instrumento Oropharyngeal MucositisSpecific Quality-of-Life (OMQoL) en pacientes pediátricos. Métodos: Estudio transversal de validación, multicéntrico, realizado para la traducción y adaptación del OMQoL del inglés al español en pacientes de entre 8 y 16 años con MO. Se midió la confiabilidad mediante el Alfa de Cronbach; la validez del contenido y el constructo, con un análisis factorial exploratorio; y la validez convergente, con las correlaciones de las escalas para MO de la Organización Mundial de la Salud (OMS), la Oropharingeal Mucositis Assessment Scale (OMAS) y con el Pediatric Quality of Life-3 (PedsQL-3) módulo cáncer en español. Resultados: Participaron en el estudio 193 niños con una media de edad de 10.91 ± 2.38 años, de los cuales 101 (52.3%) fueron de sexo femenino. En esta muestra, 80 niños (41.5%) presentaron leucemia aguda linfoblástica y 111 (57.5%) presentaron MO grado 2 y 3. El análisis factorial resultó con cuatro dimensiones con cargas > 0.40. De los 31 ítems del OMQoL, seis fueron eliminados. El Alfa de Cronbach del OMQoL español fue de 0.954. Las correlaciones de Spearman (r) con las escalas de la OMS y OMAS fueron significativas (r = −0.720 y r = −0.689; p<0.01, respectivamente); con el PedsQL-3 módulo cáncer existió una moderada correlación (r = 0.426; p < 0.01). Conclusiones: La nueva versión del OMQoL en español demostró propiedades psicométricas adecuadas, y resulta un instrumento confiable y válido para medir la CV en niños con MO.