RESUMO
In order to compare the possible relationship between urinary concentrations of boron, calcium, magnesium and phosphorus in serum and urine of postmenopausal women with and without osteoporosis, we selected 45 postmenopausal women over 47 years of age, divided into two groups: group I clinically healthy postmenopausal women and group II postmenopausal women with osteoporosis, without chronic kidney and hepatic diseases or diabetes mellitus. We determined the boron (B), phosphorus (P), total calcium (Ca) and total magnesium (Mg) in the urine of two hours, by atomic emission spectroscopy with induction-coupled plasma (ICPA-ES). Total calcium and total magnesium in serum were determined by atomic flame absorption spectroscopy (FAAS) and inorganic phosphorus in serum, and creatinine in serum and urine, by molecular absorption spectrometry. The preliminary results suggest the existence of a significant difference (p < 0.05) in boron and phosphorus concentrations in the urine of two hours between the groups. The model of linear regression analysis used showed a relationship between urinary concentrations of boron/creatinine index and calcium/ creatinine, magnesium/creatinine and phosphorus/creatinine indexes in the urine of postmenopausal women with osteoporosis.
Assuntos
Boro/urina , Cálcio/urina , Magnésio/urina , Osteoporose Pós-Menopausa/urina , Fósforo/urina , Pós-Menopausa/urina , Idoso , Boro/sangue , Boro/fisiologia , Cálcio/sangue , Creatinina/sangue , Creatinina/urina , Feminino , Homeostase , Humanos , Modelos Lineares , Magnésio/sangue , Pessoa de Meia-Idade , Modelos Biológicos , Osteoporose Pós-Menopausa/sangue , Fósforo/sangue , Pós-Menopausa/sangue , Espectrofotometria Atômica/métodosRESUMO
OBJECTIVE: To determine the prevalence of hypercalciuria (HC) in postmenopausal women with osteoporosis and its relationship with clinical data and bone mineral metabolism. SUBJECTS AND METHODS: Calciuria was measured in 24-hour urine samples of 127 women. BMD was measured in the lumbar spine and femur by dual-energy X-ray absorptiometry (DXA). RESULTS: Mean age (±SD) was 64 (±8) years. According to urinary calcium excretion, patients were divided into normo- and hypercalciuric (HC). Of the 127 patients, 19 (15%) were classified as HC. The only difference between the groups was the age of onset of menopause (46 ± 6 vs. 50 ± 3 years HC, p < 0.0005). No association was found between calciuria and age, BMI, BMD, calcium, phosphorus, PTH, and alkaline phosphatase. CONCLUSION: HC is frequent in postmenopausal women with osteoporosis, and calciuria measurement should be included in the investigation of these patients.
Assuntos
Hipercalciúria/epidemiologia , Osteoporose Pós-Menopausa/urina , Idade de Início , Métodos Epidemiológicos , Feminino , Humanos , Hipercalciúria/urina , Pessoa de Meia-IdadeRESUMO
Con el propósito de comparar la posible relación entre las concentraciones urinarias de boro y las concentraciones de calcio, de magnesio y de fósforo en suero y orina de mujeres posmenopáusicas con y sin osteoporosis, seleccionamos 45 mujeres posmenopáusicas con más de 47 años de edad, divididas en dos subgrupos: grupo I mujeres posmenopáusicas clínicamente sanas y grupo II mujeres posmenopáusicas con osteoporosis, sin enfermedades renales, hepáticas o diabetes mellitus. Se determinó el boro (B), el fósforo (P), el calcio total (Ca) y el magnesio total (Mg) en la orina de dos horas por espectroscopia de emisión atómica con plasma acoplado por inducción (ICPA-ES), el calcio y el magnesio total en suero por espectroscopia de absorción atómica en llama (FAAS) y el fósforo inorgánico en suero y la creatinina en suero y orina por espectroscopia de absorción molecular. Los resultados obtenidos sugieren preliminarmente una diferencia significativa (p<0,05) en las concentraciones de boro y de fósforo en la orina de dos horas entre los grupos estudiados. El análisis de regresión lineal aplicado, sugiere relación entre el índice boro/creatinina y los índices calcio/creatinina, magnesio/creatinina y fósforo/creatinina en la orina de las mujeres posmenopáusicas con osteoporosis.
In order to compare the possible relationship between urinary concentrations of boron, calcium, magnesium and phosphorus in serum and urine of postmenopausal women with and without osteoporosis, we selected 45 postmenopausal women over 47 years of age, divided into two groups: group I clinically healthy postmenopausal women and group II postmenopausal women with osteoporosis, without chronic kidney and hepatic diseases or diabetes mellitus. We determined the boron (B), phosphorus (P), total calcium (Ca) and total magnesium (Mg) in the urine of two hours, by atomic emission spectroscopy with induction-coupled plasma (ICPA-ES). Total calcium and total magnesium in serum were determined by atomic flame absorption spectroscopy (FAAS) and inorganic phosphorus in serum, and creatinine in serum and urine, by molecular absorption spectrometry. The preliminary results suggest the existence of a significant difference (p <0.05) in boron and phosphorus concentrations in the urine of two hours between the groups. The model of linear regression analysis used showed a relationship between urinary concentrations of boron/creatinine index and calcium/ creatinine, magnesium/creatinine and phosphorus/creatinine indexes in the urine of postmenopausal women with osteoporosis.
Assuntos
Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Boro/urina , Cálcio/urina , Magnésio/urina , Osteoporose Pós-Menopausa/urina , Fósforo/urina , Pós-Menopausa/urina , Boro/sangue , Boro/fisiologia , Cálcio/sangue , Creatinina/sangue , Creatinina/urina , Homeostase , Modelos Lineares , Modelos Biológicos , Magnésio/sangue , Osteoporose Pós-Menopausa/sangue , Fósforo/sangue , Pós-Menopausa/sangue , Espectrofotometria Atômica/métodosRESUMO
OBJETIVO: Analisar a prevalência de hipercalciúria em mulheres na pós-menopausa com osteoporose e avaliar associação de hipercalciúria com parâmetros clínicos e do metabolismo osteomineral. SUJEITOS E MÉTODOS: Foram estudadas 127 mulheres. A calciúria foi determinada em urina de 24 horas. A DMO foi medida em coluna lombar e fêmur por dupla emissão de energia (DXA). RESULTADOS: A média de idade foi de 64 ± 8 anos. De acordo com a excreção urinária de cálcio, as pacientes foram divididas em normo e hipercalciúricas (HC). Das 127 pacientes, 19 (15 por cento) foram classificadas como HC. Houve diferença entre os grupos apenas na idade de início da menopausa (46 ± 6 vs. 50 ± 3 anos HC, p < 0,0005). Não houve associação entre calciúria e idade, IMC, DMO, cálcio, fósforo, PTH e fosfatase alcalina. CONCLUSÃO: A HC é frequente em mulheres na pós-menopausa com osteoporose, e a medida da calciúria deve ser incluída na investigação dessas pacientes.
OBJECTIVE: To determine the prevalence of hypercalciuria (HC) in postmenopausal women with osteoporosis and its relationship with clinical data and bone mineral metabolism. SUBJECTS AND METHODS: Calciuria was measured in 24-hour urine samples of 127 women. BMD was measured in the lumbar spine and femur by dual-energy X-ray absorptiometry (DXA). RESULTS: Mean age (±SD) was 64 (±8) years. According to urinary calcium excretion, patients were divided into normo- and hypercalciuric (HC). Of the 127 patients, 19 (15 percent) were classified as HC. The only difference between the groups was the age of onset of menopause (46 ± 6 vs. 50 ± 3 years HC, p < 0.0005). No association was found between calciuria and age, BMI, BMD, calcium, phosphorus, PTH, and alkaline phosphatase. CONCLUSION: HC is frequent in postmenopausal women with osteoporosis, and calciuria measurement should be included in the investigation of these patients.
Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Hipercalciúria/epidemiologia , Osteoporose Pós-Menopausa/urina , Idade de Início , Métodos Epidemiológicos , Hipercalciúria/urinaRESUMO
Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (> or = 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 microg/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.
Assuntos
Dieta/métodos , Osteoporose Pós-Menopausa/sangue , Osteoporose Pós-Menopausa/urina , Vitamina D/sangue , Absorciometria de Fóton/métodos , Absorciometria de Fóton/estatística & dados numéricos , Biomarcadores/sangue , Biomarcadores/urina , Densidade Óssea , Brasil/epidemiologia , Cálcio da Dieta/administração & dosagem , Cálcio da Dieta/sangue , Estudos Transversais , Registros de Dieta , Carboidratos da Dieta/administração & dosagem , Gorduras na Dieta/administração & dosagem , Proteínas Alimentares/administração & dosagem , Ingestão de Energia , Feminino , Humanos , Pessoa de Meia-Idade , Inquéritos Nutricionais , Estado Nutricional , Osteoporose Pós-Menopausa/epidemiologia , Hormônio Paratireóideo/sangue , Fósforo na Dieta/administração & dosagem , Sódio na Dieta/administração & dosagem , Sódio na Dieta/sangue , Sódio na Dieta/urina , Vitamina D/administração & dosagemRESUMO
BACKGROUND: Calcitonin is specially indicated for the treatment of osteoporosis in women that cannot receive estrogen replacement therapy or that have a high bone turnover rate. AIM: To study the effects of low intranasal calcitonin doses on bone remodeling in postmenopausal women with a high bone turnover. PATIENTS AND METHODS: Forty one healthy women aged 56 +/- 6 years old, with a mean lapse after menopause of 7.6 +/- 6.5 years and with a high bone turnover rate, evidenced by an urinary hydroxyproline (mg/dl)/creatinine (g/dl) ratio of 52.4 +/- 7.2, were studied. They were randomly assigned to receive 100 or 50 U/calcitonin thrice a week during 3 months or to a control group that received placebo. All received 500 mg/day calcium carbonate. Urinary hydroxyproline/creatinine ratio was measured a 0, 15, 30, 60 and 90 days. Plasma bone fraction of alkanine phosphatases was measured at 0, 30 and 90 days. RESULTS: Initial urinary hydroxyproline/creatinine ratio and plasma bone fraction of alkanine phosphatases were similar in all study groups and there was no change in these parameters during the study period. CONCLUSIONS: Intranasal calcitonin in doses of 100 U thrice a week or less, does not modify accelerated bone turnover in postmenopausal women.
Assuntos
Remodelação Óssea/efeitos dos fármacos , Calcitonina/administração & dosagem , Osteoporose Pós-Menopausa/tratamento farmacológico , Fosfatase Alcalina/sangue , Análise de Variância , Calcitonina/uso terapêutico , Creatinina/urina , Método Duplo-Cego , Feminino , Humanos , Hidroxiprolina/urina , Pessoa de Meia-Idade , Osteoporose Pós-Menopausa/sangue , Osteoporose Pós-Menopausa/urina , Estudos Prospectivos , Fatores de TempoRESUMO
Níveis de hormônio paratiroidiano já foram descritos mais baixos, inalterados e até mais elevados em mulheres com osteoporose pós-menopausa. Alguns autores, ao infundirem EDTA e medirem o cálcio ionizado em mulheres menopausadas, observaram uma reatividade menor das glândulas paratiróides nessas mulheres. A resposta da glândula paratiróide ao estímulo com fosfato oral, em mulheres osteopênicas, nos primeiros anos da menopausa (1-6 anos) foi investigado. Doze mulheres osteopênicas (densidade óssea na coluna entre 0,900 e 0,970g/cm2), menopausadas, com idade entre 50 e 55 anos, e 11 mulheres saudáveis, controles (densidade óssea na coluna maior que 1.100g/cm2) receberam 1,5 gramas de fosfato oral, durante 15 dias. O cálcio, fósforo, fosfatase alcalina e creatinina séricas, bem como o Ca/Cr e hidroxiprolina/Cr urinários foram semelhantes nos dois grupos no início do estudo. Entretanto, o PTH aminoterminal foi estatisticamente inferior nas mulheres osteopênicas. Após ingestäo de fosfato oral, o Ca/Cr urinário nos dois grupos apresentou queda ao redor de 42-46%. O PTH aminoterminal subiu significantemente no grupo controle normal após administraçäo do fosfato, porém 75% das osteopênicas näo apresentaram qualquer alteraçäo. A resposta negativa nas mulheres ostopênicas pode ser devida a sensibilidade alterada ao PTH nessas pacientes. Os autores propöem novos estudos com sobrecarga de fosfato em todas as mulheres, nos primeiros anos da menopausa, para verificar se as "näo respondedoras" perdem mais massa óssea que as "respondedoras"