RESUMO
Abstract: Background: The Simplified Psoriasis Index is a tool that assesses the current severity, psychosocial impact, past history and interventions in patients with psoriasis through separate components. Two versions are available, one in which the current severity of the disease is evaluated by the patient themselves and another by the physician. Objectives: Translate the Simplified Psoriasis Index into Brazilian Portuguese and verify its validity. Methods: The study was conducted in two stages; the first stage was the translation of the instrument; the second stage was the instrument's validation. Results: We evaluated 62 patients from Complexo Hospitalar Santa Casa de Porto Alegre and Hospital Universitário de Brasília. The Simplified Psoriasis Index translated into Portuguese showed high internal consistency (Cronbach test 0.68). Study limitations: Some individuals, because of poor education, might not understand some questions of the Simplified Psoriasis Index. Conclusions: The Brazilian Portuguese version of the Simplified Psoriasis Index was validated for our population and can be recommended as a reliable instrument to assess the patients with psoriasis.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Psoríase/diagnóstico , Psoríase/classificação , Traduções , Índice de Gravidade de Doença , Brasil , Valor Preditivo dos Testes , Inquéritos e Questionários , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Características Culturais , IdiomaRESUMO
BACKGROUND: The Simplified Psoriasis Index is a tool that assesses the current severity, psychosocial impact, past history and interventions in patients with psoriasis through separate components. Two versions are available, one in which the current severity of the disease is evaluated by the patient themselves and another by the physician. OBJECTIVES: Translate the Simplified Psoriasis Index into Brazilian Portuguese and verify its validity. METHODS: The study was conducted in two stages; the first stage was the translation of the instrument; the second stage was the instrument's validation. RESULTS: We evaluated 62 patients from Complexo Hospitalar Santa Casa de Porto Alegre and Hospital Universitário de Brasília. The Simplified Psoriasis Index translated into Portuguese showed high internal consistency (Cronbach test 0.68). STUDY LIMITATIONS: Some individuals, because of poor education, might not understand some questions of the Simplified Psoriasis Index. CONCLUSIONS: The Brazilian Portuguese version of the Simplified Psoriasis Index was validated for our population and can be recommended as a reliable instrument to assess the patients with psoriasis.
Assuntos
Psoríase/diagnóstico , Adulto , Brasil , Características Culturais , Feminino , Humanos , Idioma , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Psoríase/classificação , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Inquéritos e Questionários , TraduçõesRESUMO
BACKGROUND: Von Zumbusch type of generalized pustular psoriasis is a rare variant of psoriasis in children. It can occur in patients with or without psoriasis vulgaris. OBJECTIVE: The aim of the study was to discuss the precipitating factors, clinical manifestations, laboratory data and therapy of von Zumbusch type of generalized pustular psoriasis in children from southwestern China and to improve the diagnosis and treatment level. METHODS: A retrospective analysis was conducted for inpatients aged 14 years old or less with von Zumbusch type of generalized pustular psoriasis in our department from 2005 to 2014. RESULTS: A total of 26 patients were included, of whom four (15.38%) had previous history of psoriasis vulgaris and one (3.85%) had previous history of psoriasis arthropathica. Mean onset age was 6.90 years. Gender distribution was equivalent. Incidence of the disease in summer and autumn was higher than that in winter and spring. Nineteen (73.08%) cases were triggered by infection, two (7.69%) cases were caused by sudden discontinuation of systemic use of corticosteroid. Twenty-four (92.31%) cases had concomitant fever. The initial lesion manifested as non-follicular sterile pustules on erythema. Sixteen patients responded well to acitretin, 11 to Tripterygium wilfordii Hook F (TwHF), two to cyclosporine, and one to methotrexate. STUDY LIMITATIONS: This study is a retrospective one and the number of cases is small. CONCLUSION: Von Zumbusch type of generalized pustular psoriasis is a rare disease in children, infection is the most common precipitating factor, acitretin is the first-line therapy, traditional Chinese medicine TwHF also can be used.
Assuntos
Psoríase/diagnóstico , Psoríase/tratamento farmacológico , Acitretina/uso terapêutico , Adolescente , Criança , Pré-Escolar , China , Ciclosporina/uso terapêutico , Feminino , Humanos , Lactente , Masculino , Metotrexato/uso terapêutico , Psoríase/classificação , Psoríase/etiologia , Estudos RetrospectivosRESUMO
Abstract Background: Von Zumbusch type of generalized pustular psoriasis is a rare variant of psoriasis in children. It can occur in patients with or without psoriasis vulgaris. Objective: The aim of the study was to discuss the precipitating factors, clinical manifestations, laboratory data and therapy of von Zumbusch type of generalized pustular psoriasis in children from southwestern China and to improve the diagnosis and treatment level. Methods: A retrospective analysis was conducted for inpatients aged 14 years old or less with von Zumbusch type of generalized pustular psoriasis in our department from 2005 to 2014. Results: A total of 26 patients were included, of whom four (15.38%) had previous history of psoriasis vulgaris and one (3.85%) had previous history of psoriasis arthropathica. Mean onset age was 6.90 years. Gender distribution was equivalent. Incidence of the disease in summer and autumn was higher than that in winter and spring. Nineteen (73.08%) cases were triggered by infection, two (7.69%) cases were caused by sudden discontinuation of systemic use of corticosteroid. Twenty-four (92.31%) cases had concomitant fever. The initial lesion manifested as non-follicular sterile pustules on erythema. Sixteen patients responded well to acitretin, 11 to Tripterygium wilfordii Hook F (TwHF), two to cyclosporine, and one to methotrexate. Study limitations: This study is a retrospective one and the number of cases is small. CONCLUSION: Von Zumbusch type of generalized pustular psoriasis is a rare disease in children, infection is the most common precipitating factor, acitretin is the first-line therapy, traditional Chinese medicine TwHF also can be used.
Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Psoríase/diagnóstico , Psoríase/tratamento farmacológico , Psoríase/classificação , Psoríase/etiologia , China , Metotrexato/uso terapêutico , Estudos Retrospectivos , Ciclosporina/uso terapêutico , Acitretina/uso terapêuticoRESUMO
La psoriasis es una enfermedad cutánea inflamatoria crónica, recidivante, que afecta al 2% de la población. Se clasifica de acuerdo a su apariencia morfológica. Existen formas raras excesivamente hiperqueratósicas, entre ellas la variante rupioides, de la cual se han reportado pocos casos en la literatura. Presentamos un caso clínico de psoriasis rupiodes diseminada con buena respuesta al tratamiento sistémico con acitretin
Psoriasis is a relapsing chronic inflammatory skin disease affecting about 2% of population. It is classified according morphological appearance. There are exceedingly rare hyperkeratotic forms, including rupioid variant, which few cases have been reported in the literature. A case of widespread rupioid psoriasis with good response to systemic treatment with acitretin is presented.
Assuntos
Humanos , Feminino , Adulto , Acitretina , Psoríase/classificação , Psoríase/etiologia , Bolívia , DermatopatiasRESUMO
BACKGROUND: Clinical characteristics of psoriasis vary between different races and climates. There are few data on Latin American and even fewer on Chilean patients with psoriasis. OBJECTIVES: To assess that clinical characteristics and quality of life (QoL) of a group of Chilean patients with psoriasis. METHODS: A cross-sectional, observational and analytic study was conducted at the Dermatology Department of the Clinical Hospital of the University of Chile between July 2006 and December 2008 applying an epidemiological and QoL-related survey to psoriatic patients. RESULTS: One hundred fifty-three patients with psoriasis were included in the study. The mean (SD) age was 42.7 (14.9) years and 60.1% of the patients were male. The most frequent disease subtype was plaque psoriasis (71.9%), followed by "guttatiform" (guttate morphology without confirmed streptococcal infection) psoriasis (17.7%). In 38.6% of patients, less than 10% of body surface area (BSA) was affected. Joint involvement was reported in 28.8% of patients. Those with early onset of disease (before 30 years of age) were more likely to have a positive family history of psoriasis. Hypertension and diabetes were present in 20.3% and 11.1% of patients, respectively. The mean Dermatology Life Quality Index was 14. Greater impact of the disease on QoL was associated with male sex, young age of onset, newly diagnosed disease, facial involvement, and widespread disease. CONCLUSION: Chilean patients with psoriasis have clinical characteristics and QoL comparable to patients in other countries. A notable difference, however, was the greater impact of psoriasis on the QoL of Chilean men compared to women.
Assuntos
Psoríase/epidemiologia , Qualidade de Vida , Atividades Cotidianas , Adolescente , Adulto , Idade de Início , Idoso , Artrite Psoriásica/epidemiologia , Criança , Chile/epidemiologia , Comorbidade , Estudos Transversais , Complicações do Diabetes/epidemiologia , Emoções , Dermatoses Faciais/epidemiologia , Dermatoses Faciais/psicologia , Feminino , Humanos , Hipertensão/epidemiologia , Masculino , Pessoa de Meia-Idade , Psoríase/classificação , Psoríase/genética , Psoríase/psicologia , Índice de Gravidade de Doença , Inquéritos e Questionários , Adulto JovemRESUMO
Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic patients and 151 unrelated healthy controls were included in our study. Genotyping was performed using the polymerase chain reaction and restriction fragment length polymorphism techniques. We found no overall differences in genotype distributions and allele frequencies when comparing between the two groups. When we analyzed a subset of psoriatic patients classified by onset and severity, only the -1438A allele was significantly increased in patients with late-onset psoriasis when compared with the healthy control group (chi(2) = 4.77, d.f. = 1, P = 0.029, odds ratio = 2.298 [95% confidence interval = 1.126-4.691]). This single nucleotide polymorphism may be involved in late-onset psoriasis in this Thai population.
Assuntos
Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único/genética , Psoríase/epidemiologia , Psoríase/genética , Receptor 5-HT2A de Serotonina/genética , Adulto , Idade de Início , Estudos de Casos e Controles , Feminino , Frequência do Gene/genética , Humanos , Masculino , Pessoa de Meia-Idade , Psoríase/classificação , Tailândia/epidemiologiaRESUMO
La psoriasis es una enfermedad inflamatoria crónica, medida inmunológicamente, de etiología desconocida que afecta del 1 al 3 por ciento de la poblalción mundial. Se caracteriza por la Hiperproliferación de queratinositos causada por la estimulación persistente de celulas T por inmunogenos de origen epidermico. Se asocia información dermica y secundariamente hiperplasia epidermica, suceptible de control mediante tratamiento médico prolongado, no curable, con grados diferentes de afectación. Existen múltiples tratamientos como son la terapia tópica, fototerapia y sistémica, con resultados variables. El desarrollo de la biología molecular, la ingeniería genética y biotecnología ha permitido la creación de moléculas dirigidas a etapas específicas de la patogenia de varias enfermedades mediadas por el sistema inmunitario. Estos elementos así obtenidos se denominan productos biológicos, y al uso de estos, terapia biológica. La terapia biológica en pacientes con psoriasis ha mostrado beneficios significativos con perfiles de tolerabilidad y seguridad satisfactorios. La limitación que la terapia biológica presenta dentro de las estrategias de tratamiento es definitivamente, su costo.
Psoriasis is a chronic inflammatory disease, immunologicaly mediated, of unknown etiology, affecting 1 to 3 per cent of the worldÆs population; is characterized by hiperproliferación of keratinocytes, caused by persistent stimulation of T cells by immunogens of epidermal origin, which associates skin inflammation and secondarily epidermal hyperplasia, which could control through prolonged medical treatment, not curable, with varying degrees of involvement. There are multiple treatments such as topical and systemic therapy, with varying results. The development of molecular biology, genetic engineering and biotechnology has enabled the creation of molecules aimed at specific stages of the pathogenesis of several diseases mediated by the immune system. These elements thus obtained are called biological products, and its use biological therapy. Biological therapy in patients with psoriasis has shown significant benefits with profiles of successful safety and tolerability. The restriction that the biological therapy introduced in the treatment strategies is definitely its cost.
Assuntos
Humanos , Adulto , Psoríase , Psoríase/classificação , Psoríase/fisiopatologia , Psoríase/história , Psoríase/terapia , Terapia BiológicaRESUMO
La psoriasis es una dermatosis crónica, recidivantes, que se caracteriza por la presencia de placas eritomnatosas y escamosas que ocasionan alteraciones en la calidad de vida del paciente. No existen datos epidemiológicos nacionales respecto a la psoriasis en Nicaragua. Se hizo un estudio descriptivo de corte transversal acerca del comportamiento clínicoepidemiológico de la psoriasis en el Centro Nacional de Dermatología "Dr. Francisco José Gómes Urcuyo" en el período comprendido de abril del 2004 a abril 2005 con un universo de 284 pacientes diagnósticados con psoriasis que asistieron a consulta externa y al programa de psicodermatosis y para la recolección de la información se elaboró una encuesta con preguntas cerradas y se revisaron expedientes clínicos del departamento de estadística del Hospital donde se lleno la ficha de recolección de la información. De los 284 pacientes estudiados, 162 pertenecian al sexo femenino y 122 al sexo masculino. El grupo etáreo más afectado fue el de 51 años a más. Los principales factores desencadenantes fueron el estrés, alcoholismo, fenómeno isomórfico y las infecciones en menor frecuencia, el 50 porciento de los pacientes encuestados (46) tuvieron antecedentes familiares. El 56.34 por ciento iniciaron su cuadro con psoriasis antes de los 40 años. El índice de severidad y área de psoriasis (PASI) fue de leve a moderado. La topografia más frecuente fue la forma diseminada y predominó la psoriasis en placa. Debemos continuar realizando determinaciones para tener nuestros propios marcadores para conocer el comportamiento real de la psoriasis en Nicaragua. Los resultados se encasillan dentro de los rangos de la epidemiología mundial...
Assuntos
Dermatopatias/classificação , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Psoríase/classificação , Psoríase/diagnóstico , Psoríase/epidemiologia , Psoríase/etiologia , Psoríase/psicologia , Psoríase/terapia , Fatores de Risco , NicaráguaRESUMO
Entre 1983 y 1986 Hughes describió un síndrome clínico con trombosis arteriales y venosas diseminadas asociadas a la presencia de anticuerpos dirigidos contra fosfolípidos. Inicialmente lo denominó síndrome anticardiolipina. En la actualidad se lo denomina más apropiadamente síndrome antifosfolipídico