RESUMO
Hashimoto's thyroiditis manifesting as hypothyroidism has been implicated in glomerular disorders due to autoantibody formation. Here we present the case of a 26-year-old male without any comorbidities presenting with easy fatiguability and weight gain for 2 months. He was found to have a creatinine of 2.1 mg/dL with a history of rhinitis treated with anti-histaminic three days prior to the hospital visit. He had symptoms of intermittent myalgia for the past two weeks. On laboratory evaluation, he was found to have raised CPK, elevated TSH, low normal T4, and positive anti-TPO and anti-Tg antibodies. Neck ultrasound revealed linear echogenic septations in the thyroid gland. Renal biopsy revealed acute tubular injury. Appropriate thyroxine supplementation was started and his creatinine decreased to 1.2 mg/dL after 1 month. It is important that clinicians should be aware of this rare kidney presentation in Hashimoto's thyroiditis.
Assuntos
Injúria Renal Aguda , Doença de Hashimoto , Rabdomiólise , Humanos , Doença de Hashimoto/complicações , Doença de Hashimoto/diagnóstico , Masculino , Adulto , Rabdomiólise/diagnóstico , Rabdomiólise/etiologia , Injúria Renal Aguda/etiologia , Injúria Renal Aguda/diagnóstico , Diagnóstico DiferencialRESUMO
OBJECTIVES: To analyze case reports with individual patient data belonging to the Armed Forces submitted to specific physical or military combat training that was affected by rhabdomyolysis and identify factors that influenced the diagnosis and clinical evolution of the syndrome. CONTENT: We conducted a systematic review following the PRISMA guidelines and registered on PROSPERO (CRD42021242465). We searched MedLine (via PubMed), Scopus, Cochrane, Lilacs, SciELO, CINAHL, Web of Science, SPORTDiscus, ScienceDirect, and PEDro databases for studies that reported cases of military personnel affected by rhabdomyolysis. SUMMARY AND OUTLOOK: Thirteen studies met the inclusion criteria. Forty-nine individual cases of rhabdomyolysis were analyzed. From them, it was possible to identify several associated factors, which were responsible for developing rhabdomyolysis in military personnel. Thirty military personnel (60%) practiced physical training and 20 (40%) practiced specific military combat training. The creatine kinase (CK) peak ranged from 1,040 to 410,755 U/L, with an average of 44.991 U/L, and 14 (28%) of the cases reported alteration of renal function and four militaries (8%) evolved to death condition. Physical activities performed strenuously and without proper planning conditions such as room temperature, the period without adequate water intake, the amount of equipment used during the activity contributed to the development of rhabdomyolysis in the cases of military personnel analyzed in the present study. Therefore, it is recommended that future studies investigate the relationship between the prevalence of rhabdomyolysis cases and the severity of its consequence when associated with progressive methods of training, hydration control, acclimatization to austere environments, monitoring for the existence of hereditary diseases, and control of the use of supplementary nutritional substances.
Assuntos
Militares , Rabdomiólise , Humanos , Rabdomiólise/epidemiologia , Rabdomiólise/etiologia , Rabdomiólise/diagnóstico , Exercício Físico/fisiologia , Fatores de Risco , Creatina Quinase , BiomarcadoresRESUMO
McArdle's disease, known as blockage of muscle glycogen metabolism, is characterized by glycogen accumulation of chains in skeletal striated muscles. One of the typical symptoms of the disease is the feeling of intolerance to exercise. Severe muscle cram and contracture, which often cause stiffness, occur due to a lack of muscle energy substrate during the exercise. These factors can lead to muscle damage, myoglobinuria, and, in severe cases, renal failure and rhabdomyolysis. Rhabdomyolysis is a syndrome that presents injury and necrosis of muscle cells leading to the release of intracellular material to the circulatory system. The present study aimed to report rhabdomyolysis in an individual with McArdle's disease after exercise of walking with low intensity. Patient, aged 33 years, was treated in the emergency room of a hospital located in the State of Rio de Janeiro, Brazil. After performing a full lap on the block of home (~500 m in ~4 min 37 s), walking at a moderate speed (~6.5 km/h), the individual felt sick and was rescued, later being hospitalized. The examinations collected presented hematocrit (HCT) compatible with chronic disease anemia and myoglobinuria. The patient was discharged from the intensive care center on the 3rd day, after a 45% drop in creatine kinase. The patient described in the present study achieved full recovery. Attention to symptoms, early diagnosis, and immediate treatment made it possible to interrupt the development of complications caused by rhabdomyolysis, not allowing progression to acute renal failure.
Assuntos
Doença de Depósito de Glicogênio Tipo V , Mioglobinúria , Rabdomiólise , Humanos , Doença de Depósito de Glicogênio Tipo V/complicações , Doença de Depósito de Glicogênio Tipo V/diagnóstico , Doença de Depósito de Glicogênio Tipo V/terapia , Brasil , Rabdomiólise/diagnóstico , Rabdomiólise/etiologia , Rabdomiólise/terapia , Exercício Físico , GlicogênioRESUMO
SARS-CoV-2, the cause of 2019 novel coronavirus disease (COVID-19), has shown to produce a variety of extrapulmonary manifestations. Rhabdomyolysis due to SARS-CoV-2 infection has been reported mainly in the early course of the disease. In this report, we present the case of a female patient with confirmed SARS-CoV-2 infection who recovered from respiratory compromise and developed a late-onset rhabdomyolysis successfully managed with oral corticosteroids and aggressive hydration. Prompt recognition of this underdiagnosed entity could help prevent subsequent life-threatening complications.
El SARS-CoV-2, la causa de la enfermedad por el nuevo coronavirus de 2019 (COVID-19), ha demostrado producir una variedad de manifestaciones extra pulmonares. La rabdomiólisis debida a la infección por SARS-CoV-ha sido reportada principalmente en el curso temprano de la enfermedad. En el presente informe, presentamos el caso de una paciente con infección confirmada por SARS-CoV-2 que se recuperó de neumonía por COVID-19 y posteriormente desarrolló una rabdomiólisis de inicio tardío que fue manejada con éxito con corticosteroides orales e hidratación enérgica durante el curso de la hospitalización. El reconocimiento y diferenciación oportuna de esta subdiagnosticada entidad y las manifestaciones constitucionales usuales durante el COVID-19, podrían ayudar a prevenir y tratar tempranamente complicaciones posteriores potencialmente mortales.
Assuntos
COVID-19 , Rabdomiólise , Feminino , Humanos , Rabdomiólise/diagnóstico , Rabdomiólise/etiologia , SARS-CoV-2RESUMO
Resumen El SARS-CoV-2, la causa de la enfermedad por el nuevo coronavirus de 2019 (COVID-19), ha demostrado producir una variedad de manifestaciones extra pulmonares. La rabdomiólisis debida a la infección por SARS-CoV-ha sido reportada principalmente en el curso temprano de la enfermedad. En el pre sente informe, presentamos el caso de una paciente con infección confirmada por SARS-CoV-2 que se recuperó de neumonía por COVID-19 y posteriormente desarrolló una rabdomiólisis de inicio tardío que fue manejada con éxito con corticosteroides orales e hidratación enérgica durante el curso de la hospitalización. El reconocimiento y diferenciación oportuna de esta subdiagnosticada entidad y las manifestaciones constitucionales usuales du rante el COVID-19, podrían ayudar a prevenir y tratar tempranamente complicaciones posteriores potencialmente mortales.
Abstract SARS-CoV-2, the cause of 2019 novel coronavirus disease (COVID-19), has shown to produce a variety of extrapulmonary manifestations. Rhabdomyolysis due to SARS-CoV-2 infection has been reported mainly in the early course of the disease. In this report, we present the case of a female patient with confirmed SARS-CoV-2 infection who recovered from respiratory compromise and developed a late-onset rhabdomyolysis successfully managed with oral corticoste roids and aggressive hydration. Prompt recognition of this underdiagnosed entity could help prevent subsequent life-threatening complications.
Assuntos
Humanos , Feminino , Rabdomiólise/diagnóstico , Rabdomiólise/etiologia , COVID-19 , SARS-CoV-2RESUMO
ABSTRACT: The physiological benefits of applying blood flow restriction (BFR) in isolation or in the presence of physical exercise have been widely documented in the scientific literature. Most investigations carried out under controlled laboratory conditions have found the technique to be safe. However, few studies have analyzed the use of the technique in clinical settings.To analyze how the BFR technique has been applied by professionals working in the clinical area and the prevalence of side effects (SEs) resulting from the use of this technique.This is a cross-sectional study. A total of 136 Brazilian professionals who perform some function related to physical rehabilitation, sports science, or physical conditioning participated in this study. Participants answered a self-administered online questionnaire consisting of 21 questions related to the professional profile and methodological aspects and SEs of the BFR technique.Professionals reported applying the BFR technique on individuals from different age groups from youth (≤18âyears; 3.5%) to older adults (60-80âyears; 30.7%), but mainly on people within the age group of 20 to 29 years (74.6%). A total of 99.1% of the professionals coupled the BFR technique with resistance exercise. Their main goals were muscle hypertrophy and physical rehabilitation. The majority (60.9%) of interviewees reported using BFR in durations of less than 5 minutes and the pressure used was mainly determined through the values of brachial blood pressure and arterial occlusion. Moreover, 92% of professionals declared observing at least 1 SE resulting from the BFR technique. Most professionals observed tingling (71.2%) and delayed onset of muscle soreness (55.8%). Rhabdomyolysis, fainting, and subcutaneous hemorrhaging were reported less frequently (1.9%, 3.8%, and 4.8%, respectively).Our findings indicate that the prescription of blood flow restriction technique results in minimal serious side effects when it is done in a proper clinical environment and follows the proposed recommendations found in relevant scientific literature.
Assuntos
Músculo Esquelético/patologia , Padrões de Prática Médica/estatística & dados numéricos , Fluxo Sanguíneo Regional/fisiologia , Treinamento Resistido/métodos , Adolescente , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Estudos Transversais , Feminino , Pessoal de Saúde/estatística & dados numéricos , Hematoma/epidemiologia , Hematoma/etiologia , Humanos , Hipertrofia/fisiopatologia , Hipertrofia/terapia , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/irrigação sanguínea , Pressão , Treinamento Resistido/efeitos adversos , Treinamento Resistido/estatística & dados numéricos , Rabdomiólise/epidemiologia , Rabdomiólise/etiologia , Inquéritos e Questionários/estatística & dados numéricos , Síncope/epidemiologia , Síncope/etiologia , Fatores de Tempo , Adulto JovemRESUMO
Abstract Bee venom is a natural toxin composed of several peptides. Massive envenoming causes severe local and systemic reactions. We report two cases of severe bee envenomation, of which one was fatal. We also describe clinical characteristics and immune markers. Both victims suffered from respiratory distress, renal failure, rhabdomyolysis, and shock. They required invasive mechanical ventilation, vasoactive drugs, and renal replacement therapy. Moreover, serum levels of chemokines, cytokines, and cell-free circulating nucleic acids demonstrated an intense inflammatory process. Massive envenoming produced systemic injury in the victims, with an uncontrolled inflammatory response, and a more significant chemotactic response in the fatal case.
Assuntos
Animais , Rabdomiólise/diagnóstico , Rabdomiólise/etiologia , Venenos de Abelha , Mordeduras e Picadas de Insetos/complicações , Abelhas , Brasil , BiomarcadoresRESUMO
Bee venom is a natural toxin composed of several peptides. Massive envenoming causes severe local and systemic reactions. We report two cases of severe bee envenomation, of which one was fatal. We also describe clinical characteristics and immune markers. Both victims suffered from respiratory distress, renal failure, rhabdomyolysis, and shock. They required invasive mechanical ventilation, vasoactive drugs, and renal replacement therapy. Moreover, serum levels of chemokines, cytokines, and cell-free circulating nucleic acids demonstrated an intense inflammatory process. Massive envenoming produced systemic injury in the victims, with an uncontrolled inflammatory response, and a more significant chemotactic response in the fatal case.