RESUMO
PURPOSE: Inflammatory myofibroblastic tumor (IMT) is a rare tumor composed of mesenchymal myofibroblastic spindle cells enveloped by an inflammatory infiltrate. Historically, this tumor sparked debate regarding whether it was a true malignancy with metastatic potential or merely a locally destructive physiologic inflammatory response. Few reports of IMT exist in the recent literature, with the majority of cases occurring in the pediatric population and favoring the lungs. Here we present an exceedingly rare case of IMT involving the larynx of a 22-year-old female. RESULTS: A hemorrhagic and solid mass of the right true membranous vocal fold was excised and sent for histopathological assessment. Features of the surgical specimens were diagnostic for IMT. Intralesional steroid therapy was selected for additional treatment. Panendoscopy facilitated surveillance for any additional or recurrent lesions, of which there were none. At 11 months post-excision, follow-up MRI revealed symmetric vocal cords without evidence of any masses. CONCLUSIONS: Although rare, laryngeal IMT should be considered in any patient presenting with hoarseness due to a vocal fold mass. Based on the successful treatment of our patient, we suggest that our approach of surgical excision followed by intralesional corticosteroid injection may be an efficacious treatment approach for this rare tumor. However, more research is warranted to elucidate the most effective, safe, and cost-effective treatment approach.
Assuntos
Neoplasias Laríngeas , Laringe , Feminino , Humanos , Criança , Adulto Jovem , Adulto , Neoplasias Laríngeas/diagnóstico por imagem , Neoplasias Laríngeas/cirurgia , Laringe/patologia , Prega Vocal/cirurgia , Rouquidão/patologia , Resultado do TratamentoAssuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias da Glândula Tireoide/complicações , Rouquidão/etiologia , Laringe/patologia , Linfoma/complicações , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/patologia , Tomografia Computadorizada por Raios X , Rouquidão/patologia , Biópsia por Agulha Fina , Linfoma/diagnóstico , Linfoma/patologia , Invasividade NeoplásicaAssuntos
Rouquidão/etiologia , Laringe/patologia , Linfoma/complicações , Neoplasias da Glândula Tireoide/complicações , Biópsia por Agulha Fina , Feminino , Rouquidão/patologia , Humanos , Linfoma/diagnóstico , Linfoma/patologia , Pessoa de Meia-Idade , Invasividade Neoplásica , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/patologia , Tomografia Computadorizada por Raios XRESUMO
The etiology and pathogenesis of laryngeal microwebs are heterogeneous, and in most cases they are an incidental finding. It has also been suggested that microwebs could be a familial trait, representing a postblastogenic embryonic vestigial structure that might alter the biomechanical and vibratory properties of the vocal fold. Vocal nodules are small benign swellings along the margins of the vocal cords, with preferential location at the junction of the anterior and middle thirds, and usually resulting from mechanical trauma. The authors studied a sample of 107 patients with vocal nodules, looking for a possible correlation with microwebs due to the predicted involvement in the vibration of vocal cord margins. Glottic proportion, type of glottic closure, nodule location and the main complaints in patients with microwebs were compared with those in a sample of patients without microwebs. In the present study, microwebs were found in 9.4% of the patients, who showed much smaller glottic proportion than patients with micronodules only. Furthermore, vocal nodule location was not related to the presence and/or absence of laryngeal microwebs.
Assuntos
Doenças da Laringe/etiologia , Doenças da Laringe/patologia , Prega Vocal/patologia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Glote/anatomia & histologia , Glote/fisiopatologia , Rouquidão/etiologia , Rouquidão/patologia , Humanos , Laringoscopia , Masculino , Pessoa de Meia-Idade , Análise de Regressão , Estudos RetrospectivosRESUMO
Os autores apresentam um caso de Pseudoxantoma elástico recessivo do tipo II associado em rouquidäo (hilinose cutis-like) e hiperelasticidade acentuada da pele (cutis laxa-like). Comentário, aspectos histológicos e revisäo bibliográfica