RESUMO
The disease caused by each of the four serotypes of dengue virus (DENV) have plagued humans since last century. Symptoms of dengue virus (DENV) infection range from asymptomatic to dengue fever (DF) to severe dengue disease (SDD). One third of the world's population lives in regions with active urban DENV transmission, and thousands of serologically naïve travelers visit these areas annually, making a significant portion of the human population at risk of being infected. Even though lifelong immunity to the homotypic serotype is achieved after a primary DENV infection. Heterotypic DENV infections may be exacerbated by a pre-existing immune memory to the primary infection and can result in an increased probability of severe disease. Not only, age, comorbidities and presence of antibodies transferred passively from dengue-immune mother to infants are considered risk factors to dengue severe forms. Plasma leakage and multiple organ impairment are well documented in the literature, affecting liver, lung, brain, muscle, and kidney. However, unusual manifestation, severe or not, have been reported and may require medical attention. This review will summarize and discuss the increasing reports of unusual manifestations in the clinical course of dengue infection.
Assuntos
Dengue/complicações , Dengue Grave/etiologia , Injúria Renal Aguda/etiologia , Adolescente , Criança , Pré-Escolar , Vírus da Dengue/imunologia , Humanos , Lactente , Pancreatite/etiologia , Síndrome de Reye/etiologia , Ruptura Esplênica/etiologia , Acidente Vascular Cerebral/etiologiaRESUMO
En México se carece de una cultura adecuada de lo que es la gripe o influenza y de la utilización de su vacuna, por lo que se hace una semblanza de la enfermedad y de las indicaciones de la vacuna inactivada y elaborada con subvirión, a fin de promover su empleo en el país para prevenir ese padecimiento y sus complicaciones.
Assuntos
Vírus da Influenza A , Vacinas Anti-Haemophilus , Influenza Humana , Programas de Imunização , Fatores de Risco , Hemoglobinopatias , Síndrome de Reye/etiologiaRESUMO
INTRODUCTION: Reye's syndrome is a metabolic encephalopathy of infancy which is often fatal. Epidemiological studies have shown associated factors including having taken Aspirin for viral illness. Some patients with this disorder may have preexisting organic acidemia such as dicarboxylic aciduria. OBJECTIVE: To study the behavior of Reye's syndrome in a group of patients during the years 1990-1996 in a provincial paediatric hospital and review variables such as age, sex, race, prodromal illness, previous consumption of Aspirin, hospital stay, mortality, diagnosis of dicarboxylic aciduria, etc. PATIENTS AND METHODS: We selected patients with Reye's syndrome seen during the period mentioned and considered the above variables. RESULTS: All 10 patients seen with Reye's syndrome were boys. Their ages were between 3 months and 2 years. Most (nine) of the patients were Caucasian. All patients had influenza as the prodromal illness, and all took Aspirin as an antipyretic. There was considerable variation in the length of their stay in the hospital. In our series there was a high mortality and only two patients survived. One boy had dicarboxylic aciduria. CONCLUSIONS: The fatal character of Reye's syndrome has been shown, as has its relation to the use Aspirin. In our environment there seems to be a tendency for Caucasian boys to be affected.
Assuntos
Síndrome de Reye/mortalidade , Anti-Inflamatórios não Esteroides/efeitos adversos , Aspirina/efeitos adversos , Pré-Escolar , Cuba , Feminino , Hospitalização , Hospitais Comunitários , Humanos , Lactente , Tempo de Internação , Masculino , Estudos Retrospectivos , Síndrome de Reye/etiologia , Síndrome de Reye/reabilitaçãoRESUMO
Reye's syndrome is considered a disease of the pediatric age. It is characterized by a prodrome of viral illness followed by vomiting and encephalopathy with associated hepatic dysfunction. This syndrome is potentially life-threatening with high morbidity and mortality rates. There are 27 other cases of adult onset Reye's syndrome reported in the literature. We describe a 18-year-old woman who developed varicella and four days later started with vomiting, delirium and in the following day she became comatose. Laboratory tests of liver function and pathology of a liver biopsy proved the diagnosis. The patient survived. A review of the proposed pathogenic mechanisms are presented. Our patient represents case the number 28 in world literature and the first in the mexican literature.
Assuntos
Síndrome de Reye/etiologia , Adolescente , Feminino , Humanos , Síndrome de Reye/diagnósticoRESUMO
Se describe el caso de una mujer joven atendida en el hospital San Ignacio (Santa Fe de Bogotá), con diagnostico post mortem de síndrome de Reye. Seguidamente, se revisan y discuten los aspectos fisiopatológicos y los concernientes al diagnóstico y la terapéutica.
Assuntos
Humanos , Feminino , Adulto , Vírus da Influenza B/patogenicidade , Síndrome de Reye/complicações , Síndrome de Reye/diagnóstico , Síndrome de Reye/epidemiologia , Síndrome de Reye/etiologia , Síndrome de Reye/fisiopatologia , Síndrome de Reye/mortalidade , Síndrome de Reye/patologia , Síndrome de Reye/tratamento farmacológico , Síndrome de Reye/terapiaRESUMO
Free and acylcarnitine in serum and urine samples were measured in five patients with hyperammonemia associated with anticonvulsant therapy including sodium valproate, of whom three had a Reye-like syndrome. All had considerable reduction in serum free carnitine and slight increase of acylcarnitine concentrations, suggesting increased conversion of free to acylcarnitine by valproate administration. Urinary excretion of both free and acylcarnitine was increased, accompanied by depressed reabsorption of free carnitine and decreased acylcarnitine/free carnitine clearance ratio. These results indicate a decreased threshold for free carnitine. The combination of these several factors may be responsible for carnitine deficiency in patients with hyperammonemia taking valproate.
Assuntos
Amônia/sangue , Carnitina/deficiência , Rim/metabolismo , Ácido Valproico/efeitos adversos , Carnitina/análogos & derivados , Carnitina/sangue , Carnitina/urina , Epilepsia/complicações , Epilepsia/tratamento farmacológico , Humanos , Lactente , Deficiência Intelectual/complicações , Taxa de Depuração Metabólica , Síndrome de Reye/etiologia , Síndrome de Reye/metabolismoRESUMO
The medium-chain acyl-CoA dehydrogenase (MCAD) deficiency of mitochondrial beta oxidation has been identified in two asymptomatic siblings in a family in which two previous deaths had been recorded, one attributed to sudden infant death syndrome and the other to Reye syndrome. Recognition of this disorder in one of the deceased and in the surviving siblings was accomplished by detection of a diagnostic metabolite, octanoylcarnitine, using a new mass spectrometric technique. This resulted in early treatment with L-carnitine supplement in the survivors, which should prevent metabolic deterioration. Further studies suggest that breast-feeding may be protective for infants with MCAD deficiency. Families with children who have had Reye syndrome or in which sudden infant death has occurred are at risk for MCAD deficiency. We suggest that survivors and asymptomatic siblings should be tested for this treatable disorder.
Assuntos
Acil-CoA Desidrogenases/deficiência , Síndrome de Reye/etiologia , Morte Súbita do Lactente/etiologia , Acil-CoA Desidrogenase , Adulto , Aleitamento Materno , Carnitina/análogos & derivados , Carnitina/sangue , Carnitina/uso terapêutico , Carnitina/urina , Pré-Escolar , Feminino , Humanos , Lactente , Espectrometria de Massas , Síndrome de Reye/genética , Síndrome de Reye/prevenção & controle , Risco , Morte Súbita do Lactente/prevenção & controleRESUMO
Una muestra de hígado humano fue obtenida de la autopsia practicada a un paciente admitido en el Hospital Universitario de Los Andes, Mérida, Venezuela. El paciente quien parecía sufrir una enfermedad la cual fue referida al Síndrome de Reye, presentó entre otros hallazgos: degeneración grasa y en largamiento del hígado, encefalopatía y hemorragia de la tráquea, de la mucosa del ileum y del ciego. Este reporte presenta evidencia de la presencia de Aflatoxina B1 en el tejido hepático. Ningún otro metabolito fue detectado. Un número de reportes han sido asociados con el Síndrome de Reye y la presencia de Aflatoxina B1 en tejido, pero hasta ahora, ésta es la primera evidencia reportada en nuestro país