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Organic chemicals identified in raw landfill leachate (LL) and their transformation products (TPs), formed during Fenton treatment, were analyzed for chemical safety following REACH guidelines. The raw LL was located in the metropolitan region of Campina Grande, in northeast Brazil. We elucidated 197 unique chemical structures, including 154 compounds that were present in raw LL and 82 compounds that were detected in the treated LL, totaling 39 persistent compounds and 43 TPs. In silico models were developed to identify and prioritize the potential level of hazard/risk these compounds pose to the environment and society. The models revealed that the Fenton process improved the biodegradability of TPs. Still, a slight increase in ecotoxicological effects was observed among the compounds in treated LL compared with those present in raw LL. No differences were observed for aryl hydrocarbon receptor (AhR) and antioxidant response element (ARE) mutagenicity. Similar behavior among both raw and treated LL samples was observed for biodegradability; Tetrahymena pyriformis, Daphnia magna, Pimephales promelas and ARE, AhR, and Ames mutagenicity. Overall, our results suggest that raw and treated LL samples have similar activity profiles for all endpoints other than biodegradability.

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In this study, the inherent safety analysis of large-scale production of chitosan microbeads modified with TiO2 nanoparticles was developed using the Inherent Safety Index (ISI) methodology. This topology was structured based on two main stages: (i) Green-based synthesis of TiO2 nanoparticles based on lemongrass oil extraction and titanium isopropoxide (TTIP) hydrolysis, and (ii) Chitosan gelation and modification with nanoparticles. Stage (i) is divided into two subprocesses for accomplishing TiO2 synthesis, lemongrass oil extraction and TiO2 production. The plant was designed to produce 2033 t/year of chitosan microbeads, taking crude chitosan, lemongrass, and TTIP as the primary raw materials. The process was evaluated through the ISI methodology to identify improvement opportunity areas based on a diagnosis of process risks. This work used industrial-scale process inventory data of the analyzed production process from mass and energy balances and the process operating conditions. The ISI method comprises the Chemical Inherent Safety Index (CSI) and Process Inherent Safety Index (PSI) to assess a whole chemical process from a holistic perspective, and for this process, it reflected a global score of 28. Specifically, CSI and PSI delivered scores of 16 and 12, respectively. The analysis showed that the most significant risks are related to TTIP handling and its physical-chemical properties due to its toxicity and flammability. Insights about this process's safety performance were obtained, indicating higher risks than those from recommended standards.

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Introducción: El manejo de los productos químicos peligrosos en la comunidad no se realiza de manera segura y responsable. Objetivo: Evaluar el nivel de seguridad de la comunidad en el manejo de los productos químicos peligros. Métodos: Investigación exploratoria-descriptiva realizada en el consejo popular Pogolotti-Finlay-Belén perteneciente al municipio Marianao, comprendida entre los años 2013-2015. Se contó con una población de 1142 practicantes sistemáticos en el manejo de los productos químicos peligrosos. La muestra fue de 177 personas, se obtuvo de forma no probabilista y seleccionada de forma intencional. Se confeccionó una lista de verificación para aplicar el método de evaluación del nivel de seguridad con objetivos específicos y contenidos de cada escalón de defensa, para la comunidad seleccionada: Escalón 0: diseño de la defensa en profundidad; Escalón 1: Prevención de Sucesos Anormales; Escalón 2: Liquidación de sucesos anormales y Escalón 3: Mitigación de accidentes. Resultados: Los conjuntos definidos como aspectos de seguridad dominantes se calificaron de inaceptable-crítico o inaceptable-extremo en esta localidad; lo que implica la toma de medidas urgentes por los bajos valores del nivel de seguridad existente. Discusión: En el grupo de estudio se identificaron dificultades en la evaluación del riesgo en el contexto comunitario que muestran, luego del análisis de sensibilidad exhaustivo, que las acciones a emprender para revertir la situación inicial no requieren en su mayoría de recursos materiales, con un costo significativo para llegar al estado deseado; sin embargo, este estado puede alcanzarse con la aplicación de un grupo de medidas de orden organizativo y de gestión(AU)

Introduction: the management of hazardous chemicals in the community is not carry on a safe and responsible ways. Objective: to assess the safety level of the selected community in the management of chemicals hazards. Methods: exploratory-descriptive research conducted in the popular council Pogolotti-Finlay-Belen in the municipality of Marianao, between the years 2013-2015. There was a population of 1142 systematic practitioners in the handling of hazardous chemicals. The sample was 177 people; was obtained non-probabilistically and was intentionally selected. An exhaustive checklist was prepared for applying the safety level assessment method (ENS), with specific objectives and contents of each defense echelon: Echelon 0: Design of the Defense in Depth; Echelon 1: Prevention of Abnormal Events; Echelon 2: Control of Abnormal Events and Echelon 3: Accidents mitigation. Results: The sets defined as safety dominant aspects are classified as Unacceptable-Critical (I-C) or Unacceptable-Extreme (I-E) in this neighborhood; what implies the taking of urgent measures by the low values of the existing safety level. Conclusions: In the group of study, difficulties were identified in the evaluation of the risk in the community context that show, after the analysis of exhaustive sensitivity, that the actions to be taken to revert the initial situation, do not require of material resources with a significant cost to reach the desired state; however, this state can be achieved through the application of a group of organizational and management measures(AU)

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Introdução: O acidente ocorrido em Santa Maria-RS encontra-se dentre os mais propalados pela mídia inclusive com repercussão internacional. A investigação criminal, levada a cabo pela delegacia de polícia e também a feita pelos técnicos do conselho regional de engenharia, resultou em um conhecimento dos fatos imediatos, ou seja, um olhar da relação causa e efeito, nitidamente estabelecida sem buscar as razões de origem das causas. Em outros termos, aqui buscamos contextualiza o evento acidentário dentro dos fatores culturais, políticos, regulatórios e econômicos. Ao não colocar luzes sob tais aspectos correlacionados, o retorno da experiência, o aprendizado e a própria gestão de riscos, ficaram circunscritos à esfera proximal do acidente. Questões sobre o uso e comercialização de materiais pirotécnicos, o emprego de materiais de revestimentos em boates e clubes noturnos, a promoção de eventos com grande afluxo de pessoas para locais fechados, não são aprofundados nos referidos relatórios. Também não se discutiu, de forma ampla, questões sobre a atuação de órgãos públicos na concessão de funcionamento de boates, sobre o papel dos especialistas em prevenção de risco, sobre o papel dos agentes públicos em grandes desastres e acidentes ampliados, especialmente os relacionados ao acidente químico que neste caso matou, em minutos, duzentos e quarenta e dois jovens, todos levados a óbitos pela ação do gás cianídrico.

Introduction: The accident in Santa Maria - RS is one of the most publicized by the media having international repercussions. The criminal investigation conducted by the police and also by the technicians of the Regional Engineering Board, resulted in an understanding of immediate facts, i.e., the causes and effects which clearly established without seeking for the roots of the problem. In other words, here we seek to contextualize the accident within the cultural, political, regulatory and economic aspects. If we did not analyze the correlated aspects, the feedback, learning and risk management itself would be restricted to the accident proximal sphere. Questions about the use and sale of fireworks, the use of lining materials in clubs and nightclubs, the organization of events with large amounts of people indoors, are not detailed in the reports. It was also not broadly discussed questions about the role of governmental agencies in providing operating licenses for nightclubs, the role of risk prevention experts and the role of public officials in major disasters and major accidents, especially those related to chemical substances, that, in this case, killed two hundred forty two young people in a few minutes, all of whom died due to the action of the cyanide gas. Objectives: In face of these and other shortcomings, this paper proposes a method of coping with these issues

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Objetivo: A Lei 7802/89 (Lei dos Agrotóxicos) foi considerada importante avanço para enfrentar problemas ambientais e de saúde provocados por agrotóxicos. Este estudo buscou avaliar o impacto da Lei e respectiva regulamentação na classificação toxicológica, na classificação de potencial de periculosidade ambiental dos agrotóxicos e nas intoxicações registradas. Métodos: Analisou-se a correlação entre vendas de agrotóxicos e registros de intoxicações no Brasil, de 1985 a 1999, utilizando Coeficiente de Correlação Linear de Pearson e Análise de Regressão. Os testes Qui-Quadrado de Tendência em Dados Ordenáveis e Coeficiente de Kappa foram utilizados para comparar o conjunto de substâncias que estava registrado em 1990 com o que estava registrado em 2000, segundo a classificação de periculosidade da Organização Mundial da Saúde. Analisaram-se as culturas/produtos de destinação permitidas, a classificação toxicológica e a de periculosidade ambiental dos produtos registrados após a Lei. Resultados: A correlação entre vendas e intoxicações foi positiva (r=0,82 ; p<0,0001). Obteve-se equação intox = 0,00236 x vendas (US$ 1,000.00) que permite estimar intoxicações registradas segundo vendas de agrotóxicos (R2=0,95; F=253,48; p<0,0001). Não houve diferenças significativas na classificação toxicológica e ambiental dos conjuntos de substâncias registradas antes-depois da Lei. Os registros posteriores à Lei continuaram privilegiando culturas de maior expressão econômica e agrotóxicos derivados de substâncias registradas antes da Lei. Produtos mais tóxicos foram registrados para finalidade que contava com outros menos tóxicos. Conclusões: Após dez anos não se consolidaram avanços esperados com a Lei. Recomendou-se: aplicar legislação com maior eficácia, priorizar registros de menor impacto, restringir produtos de maior periculosidade

Objective. The 1989 Brazilian's pesticide legislation (Law n° 7802/89) was considered an important improvement to control environmental and health problems. This study aimed to evaluate the impact of the law and it's regulations to the toxicological and environmental classifications of pesticides by hazard and to the notified poisonings. Methods. Pearson Correlation and Regression Analysis were used to evaluate the correlation between pesticide sales and notified intoxications in Brazil, from 1985 to 1999. Kappa Coefficient and Ridit Analysis (Relative Identified Distribution Analysis) were used to compare the WHO (World Health Organization) classification of pesticides by hazard of the group of chemicals that was registered in 1990 and the group registered in 2000. The toxicological and environmental classifications and the allowed destinations of the pesticides that were registered after the law were also analyzed. Results. The correlation among sales of pesticides and poisonings was positive (r=0,82 ; p<0,0001). The equation obtained make possible to estimate poisonings notifications using values of pesticides sales (R =0,95; F=253,48; p<0,0001): intox = 0,00236 x sales (US$ 1,000.00) . No significant toxicological and environmental classifications differences were identified between the groups of pesticides that were registered in 1990 and 2000. The most economical expressive crops received the majority of the registers. More toxic pesticides were registered to destinations that had less toxic ones. Conclusions. After ten years of Law it was not possible to consolidate the expected improvements. Recommendations included: enforcement of the law, priority to less risky pesticides, restriction to more toxic ones

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El Centro Panamericano de Ecología Humana y Salud (ECO/OPS/OMS) y el Programa Internacional de Seguridad de las Sustancias Químicas (PISSQ/OMS) tradicionalmente han apoyado la realización de talleres internacionales sobre diversas áreas de la toxicología. En esta ocasión se complace publicar el libro "Toxicología prospectiva y seguridad química", el cual contiene algunas de las conferencias presentadas en el Curso Intensivo sobre Toxicología Prospectiva y Seguridad Química y del Taller sobre Evaluación del Riesgo de Sustancias Químicas, organizados por la Universidad Estatal de Campinas (UNICAMP) y la Fundación Oswaldo Cruz (FIOCRUZ), del Ministerio de Salud de Brasil. Se realizaron en Río de Janeiro, Brasil, del 4 al 15 y del 18 al 20 de julio de 1988, respectivamente.

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[Objetivos] El presente está destinado a usarse como material didáctico, en cursos cortos. Para capacitaciones de profesionales que estén trabajando en la industria o bien en diferentes organismos gubernamentales, sus áreas de interés estarán relacionadas con la toxicología ocupacional o salud ocupacional y requerirán de conocimientos de toxicología para cumplir con las actividades.

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[Prólogo] Esta guía proporciona la instrucción técnica que se debe utilizar en la descontaminación del equipo usado por los bomberos que ha estado expuesto a metriales peligrosos.

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