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Syringomatous tumor of the nipple is a benign, locally infiltrative tumor. There are reports in the literature of tumor recurrence in cases of incomplete excision. Clinical and mammographic findings in syringomatous tumors are like those of breast carcinoma and the pathologist has a fundamental role in final tumor diagnosis. Therefore, the aim of this study was to report a case of syringoma located in the areolar region. A 33-year-old woman reported that she had noticed a nodule in her left areolar region 4 years previously (February 2019). A breast ultrasound was performed, detecting intraparenchymatous breast cysts. Surgical resection of the nodule was indicated although it was not performed. Two years later, in August 2021, the patient underwent a mastopexy with prosthesis inclusion. Histopathology study of the surgical specimen revealed a syringomatous tumor with positive margins. Thirteen (13) months after diagnosis (September 3, 2021 - October 16, 2022), the patient is doing well and receives clinical follow-up.

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INTRODUCCIÓN: Los siringomas son tumores benignos derivados de la porción intraepidérmica de los conductos sudoríparos ecrinos. Ocasionalmente pueden iniciar de forma súbita como siringomas eruptivos o localizarse en sitios atípicos que retrasan el diagnóstico por años. La dermatoscopía tiene un rol incipiente en diferenciar siringomas de su extenso diagnóstico diferencial. MÉTODOS: Estudio retrospectivo descriptivo de serie de casos de siringomas de localización atípica. Los datos fueron extraídos de fichas clínicas electrónicas. Todos incluyen dermatoscopía y correlación histopatológica. RESULTADOS: Cinco pacientes. Cuatro hombres y una mujer entre 40 y 79 años de edad con siringomas atípicos: cuatro casos eruptivos y un caso de siringomas vulvares. DISCUSIÓN: Proponemos la dermatoscopía basada en nuestros hallazgos como una herramienta útil con estructuras ovales amarillas y una pseudo-red café clara difusa en su superficie. Estas estructuras amarillas se pueden correlacionar con la proliferación ductal ecrina y el denso estroma en la histopatología. CONCLUSIÓN: Enfatizamos que se debe considerar esta entidad en el diagnóstico diferencial de dermatosis papulares y conocer sus manifestaciones clínicas para optimizar la sospecha diagnóstica.

INTRODUCCTION: Syringomas are common benign tumors, probably of origin derived from the intraepidermal portion of the eccrine sweat ducts. Occasionally they may develop suddenly and extensively as eruptive syringomas or be located in atypical sites delaying the diagnosis for years. Dermoscopy has an incipient role in differentiating syringomas from their extensive differential diagnosis. METHODS: Retrospective descriptive case-series study of atypical location syringomas. Data extraction from clinical history from electronic files. They all include dermoscopy and histopathological correlation. RESULTS: Five patients: Four men and one woman between 40 and 79 years old, with atypical syringomas diagnosis: four eruptive and one vulvar syringomas. DISCUSSION: We propose dermoscopy, based on our findings, as a useful tool to this entity, with its oval yellow structures and a diffuse light-brown network-like structure on its surface. These yellow enlargements may be correlated with the ductal eccrine proliferation and the dense stroma seen in the histopathology. CONCLUSION: We emphasize that they should be considered in the differential diagnosis of papular dermatosis, as they tend to be underdiagnosed, and to know their clinical manifestations to optimize the diagnostic suspicion.

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Los siringomas son nevos benignos derivados del epitelio ductal intraepidermico de las glándulas sudoríparas ecrinas (acrosiringio). Predomina en mujeres y la variedad más frecuente es la de localización palpebral. La forma eruptiva es rara. Presentamos un varón de 29 años de edad, con siringomas múltiples eruptivos y compromiso en cara, antebrazos,abdomen y muslos con poca respuesta a tretinoína...

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Our patient is a 29-year-old woman without any previous disease who presented with different kinds of lesions on her face, neck, and chest. She first noticed the lesions 10 years ago and, since that time, they have become more numerous. She has no affected relatives. On physical examination, she had multiple cystic lesions on her neck, chest, and vulva, which were between 0.3 cm and 1 cm and skin-colored or yellowish (Figure 1). She presented with small, white papules on her face measuring approximately 0.2 cm, localized on her forehead and cheeks. Some of these papules had a blueish appearance (Figure 2). She also presented clinically typical eruptive syringomas on her upper and lower eyelids and neck and multiple facial milia. Finally, a sacrococcygeal pilonidal cyst was diagnosed and surgically removed. Her nails and teeth were clinically normal. Biopsies of each kind of lesion were performed, with the following results: (1) neck cystic lesion: steatocystoma; (2) small, white facial papule: eccrine hidrocystoma; (3) blueish facial papule: apocrine hidrocystoma; and (4) small neck papule: syringoma (Figure 3). With these findings, our diagnosis was steatocystoma multiplex with multiple eccrine and apocrine hidrocystomas, eruptive syringomas, and sacrococcygeal pilonidal cyst.

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An 8-year-old girl was referred for evaluation of multiple lesions on the neck, axillae, and genitalia. A great number of milia-like lesions were also noticed on the palms and discrete keratotic plugs on the soles. Histopathology from lesions on the neck, axilla, and vulva were consistent with syringoma. On the palms and soles, eccrine ducts cystically dilated filled with proteinaceous material and calcifications were found. Although the nature of palmar and plantar lesions in our patient is uncertain, we think that they should be related to the other syringomas on her skin.

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Syringomas are benign adnexal tumors derived from the intraepidermal portion of eccrine sweat ducts. Clinically, they usually appear as small yellow or skin-colored papules ranging from 1-3 mm in diameter on the lower eyelids. The condition of eruptive syringomas is a clinically distinct, uncommon variant of syringomas. This entity was first recognized by Darier and Jacquet in 1887. Since the initial description, less than 100 cases have been reported to date. Although eruptive syringomas can develop on various sites of the body, instances of widespread involvement, known as generalized eruptive syringoma, are rare. In this paper, we present a case of generalized eruptive syringoma on a 26-year-woman. She exhibited multiple, eruptive asymptomatic papules, symmetrically distributed on the face, scalp, upper and lower extremities, chest, and abdomen.

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Los siringomas son tumores anexiales benignos que derivan del conducto sudoríparo ecrino. Suelen presentarse luego de la pubertad, con mayor incidencia en el sexo femenino. Se manifiestan clínicamente como pápulas rosadas pequeñas, localizadas en cara, cuello y región del escote. Las mismas son asintomáticas, aunque ciertos pacientes pueden referir prurito. La anatomía patológica de la lesión se caracteriza por proliferaciones epiteliales de dos líneas de células y, según el plano de corte, se puede observar la clásica imagen “en cola de renacuajo”. Existen numerosas alternativas terapéuticas para su tratamiento, si bien ninguna de ellas es totalmente satisfactoria. Presentamos el caso de una paciente adolescente, evaluada en nuestro servicio, con siringomas múltiples localizados.

Syringomas are benign adnexal tumors derived from eccrine duct. They occur predominantly after puberty with higher incidence in females. Clinically, they present as small rose-colored papules usually localized on the face, neck and upper aspect of chest. The lesions are generally asymptomatic, although some patients may complain of pruritus. Histopathology it is characterized by epithelial proliferation of two cell layers and, depending upon the plane of section, the classic tadpole appearance may be observed. Numerous treatment options exist, none of which are totally satisfactory. We report a case of a female adolescent with multiple localized syringomas that was seen in our Dermatology department.

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El siringoma es una neoplasia cutánea benigna rara, originada de las glándulas sudoríparas ecrinas. Clínicamente se manifiesta como múltiples pápulas, pequeñas de 1-5mm en los párpados y en el área superior de mejilla. Se presenta más frecuentemente en mujeres e inicia durante o después de la pubertad. El diagnóstico clínico es difícil por la infrecuencia del cuadro y su semejanza con otras patologías, pero su histología es característica. Presentamos el caso de una paciente femenina de 51 años de edad a quien se le diagnosticó siringomas por clínica y estudio histopatológico...

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El siringoma es una neoplasia cutánea benigna rara, originada de las glándulas sudoríparas ecrinas. Clínicamente se manifiesta como múltiples pápulas, pequeñas de 1-5mm en los párpados y en el área superior de mejilla. Se presenta más frecuentemente en mujeres e inicia durante o después de la pubertad. El diagnóstico clínico es difícil por la infrecuencia del cuadro y su semejanza con otras patologías, pero su histología es característica. Presentamos el caso de una paciente femenina de 51 años de edad a quien se le diagnosticó siringomas por clínica y estudio histopatológico...(AU)

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