RESUMO
Pregnant rats were subjected to 50% food restriction during the first or the second half of pregnancy, or throughout pregnancy. The effects of intrauterine food restriction, on kidney function and morphometry were studied in newborn and adult (3 months) offspring. No differences in glomerular diameter were observed in newborn restricted rats compared with controls. The number of glomeruli was significantly lower both in newborn and 3-month-old restricted rats. However, glomerular diameter was increased in 3-month-old rats, which suggests that hypertrophic stimuli were present. The medulla/cortex ratio increased in adult rats submitted to food restriction during pregnancy, a finding that agrees with the preserved sodium and acid excretion, and the normal osmolar and free water clearance observed in these groups. These results show that the reduction in glomerular number is still present 3 months after birth in the progeny of mothers submitted to severe food restriction during pregnancy, suggesting impairment of glomerulogenesis even after birth. Intra utero undernutrition can be regarded as an experimental model of glomerular hypertrophy.
Assuntos
Rim/patologia , Rim/fisiopatologia , Distúrbios Nutricionais/patologia , Distúrbios Nutricionais/fisiopatologia , Acidose/etiologia , Animais , Peso Corporal/fisiologia , Feminino , Sistema Justaglomerular/patologia , Sistema Justaglomerular/fisiopatologia , Testes de Função Renal , Glomérulos Renais/patologia , Glomérulos Renais/fisiopatologia , Túbulos Renais/patologia , Túbulos Renais/fisiopatologia , Masculino , Distúrbios Nutricionais/metabolismo , Tamanho do Órgão/fisiologia , Concentração Osmolar , Gravidez , Complicações na Gravidez , Ratos , Ratos Wistar , Sódio/urinaAssuntos
Angiotensina II/metabolismo , Sistema Justaglomerular/fisiopatologia , Cirrose Hepática/fisiopatologia , Renina/metabolismo , Aldosterona/metabolismo , Angiotensina II/fisiologia , Animais , Pressão Sanguínea , Cães , Humanos , Sistema Justaglomerular/ultraestrutura , Potássio/metabolismo , Sódio/metabolismo , Equilíbrio HidroeletrolíticoRESUMO
Batter's syndrome is characterized by retardation in growth pitressin-resistant hypostenuria, hypokalemic alkalosis, high activity of the jux angiotensin-renine-aldosterone system with normal blood pressure; vascular insensibility to angiotensin and hypertrophy and hyperplasia of the juxtaglomerular apparatus. In both patients we studied, we found negative balance of sodium and potassium conditioned to a renal loss of them.
Assuntos
Síndrome de Bartter/fisiopatologia , Hiperaldosteronismo/fisiopatologia , Sistema Justaglomerular/fisiopatologia , Síndrome de Bartter/diagnóstico , Pré-Escolar , Feminino , Taxa de Filtração Glomerular , Humanos , Masculino , Potássio/urina , Sódio/urina , Equilíbrio HidroeletrolíticoAssuntos
Hipertensão/etiologia , Sistema Justaglomerular/fisiopatologia , Renina/metabolismo , Injúria Renal Aguda/etiologia , Anti-Hipertensivos/uso terapêutico , Criança , Doença Crônica , Feminino , Humanos , Hiperaldosteronismo/complicações , Hiperaldosteronismo/tratamento farmacológico , Hipertensão Renal/tratamento farmacológico , Hipertensão Renal/etiologia , Sistema Justaglomerular/efeitos dos fármacos , MasculinoRESUMO
Serum angiotensin-I-converting enzyme activity was found to be elevated in infants with idiopathic respiratory distress syndrome when compared with healthy premature infants, normal infants, and acutely ill full-term infants. Serum and lung CE activity has been found to be elevated in mice exposed to hypobaric alveolar hypoxia which also stimulated renal renin production. These findings suggest that alveolar hypoxia stimulates the renin-angiotensin-aldosterone system and this system may be involved in the response to the stress of IRDS.