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1.
Nutrients ; 16(15)2024 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-39125317

RESUMO

There is evidence that both intra-serial variable resistance (I-sVR), as pre-activation within the post-activation performance enhancement cycle (PAPE), and creatine and caffeine supplementation increase athletic performance in isolation. However, the effect of the three conditioning factors on 30 m repeated sprint ability (RSA) performance in young soccer players is unknown. This study determined the summative and isolation effect of ergogenic aids and pre-activation in half-back squats (HBSs) with I-sVR on performance in an RSA test in young soccer players. Twenty-eight young soccer players were randomly assigned to either EG1 (n = 7, creatine + caffeine + I-sVR), EG2 (n = 7, creatine + placebo2 + I-sVR), EG3 (n = 7, placebo1 + caffeine + I-sVR), or EG4 (n = 7, placebo1 + placebo2 + I-sVR), using a factorial, four-group-matched, double-blind, placebo-controlled design. Creatine supplementation included 0.3 g/kg/day for 14 days, caffeine supplementation included 0.3 mg/kg per day, and pre-activation in HBS with I-sVR (1 × 5 at 30% 1RM [1.0-1.1 m/s] + 1 × 4 at 60% 1RM [0.6-0.7 m/s]). The RSA test and HBS outcomes were evaluated. Three-way ANOVA showed non-significant differences for the RSA test and HBS outcomes (p > 0.05). At the end of this study, it was found that the three ergogenic aids, together, do not generate a summative effect on the physical performance of young soccer players. However, it is important to analyze individual responses to these specific protocols.


Assuntos
Desempenho Atlético , Cafeína , Creatina , Suplementos Nutricionais , Corrida , Futebol , Humanos , Futebol/fisiologia , Cafeína/administração & dosagem , Cafeína/farmacologia , Desempenho Atlético/fisiologia , Creatina/administração & dosagem , Creatina/farmacologia , Adolescente , Masculino , Método Duplo-Cego , Corrida/fisiologia , Treinamento Resistido , Substâncias para Melhoria do Desempenho/administração & dosagem , Substâncias para Melhoria do Desempenho/farmacologia , Atletas
2.
Nutrients ; 16(13)2024 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-38999769

RESUMO

Caffeine is a well-described ergogenic aid used to enhance athletic performance. Using animal models can greatly increase our understanding of caffeine's mechanisms in performance. Here, we adapted an animal weight-lifting exercise model to demonstrate caffeine's ergogenic effect in rats. Male Wistar rats (315 ± 35 g) were randomly divided into two groups: one group received 5 mg·kg-1 of caffeine (0.5 mL; CEx; n = 5) and the other 0.9% NaCl (0.5 mL; PEx; n = 4) through an orogastric probe (gavage) one hour before exercise. Weight-lifting exercise sessions were performed over three subsequent days, and the number of complete squats performed was counted. Analyses of the area under the curve in all three experiments showed that the CEx group responded more to stimuli, performing more squats (1.7-, 2.0-, and 1.6-fold; p < 0.05) than the control group did. These three days' data were analyzed to better understand the cumulative effect of this exercise, and a hyperbolic curve was fitted to these data. Data fitting from the caffeine-supplemented group, CEx, also showed larger Smax and Kd (2.3-fold and 1.6-fold, respectively) than the PEx group did. Our study demonstrated an acute ergogenic effect of caffeine in an animal weight-lifting exercise model for the first time, suggesting potential avenues for future research.


Assuntos
Cafeína , Ratos Wistar , Levantamento de Peso , Animais , Cafeína/farmacologia , Cafeína/administração & dosagem , Masculino , Projetos Piloto , Ratos , Levantamento de Peso/fisiologia , Condicionamento Físico Animal/fisiologia , Substâncias para Melhoria do Desempenho/farmacologia , Substâncias para Melhoria do Desempenho/administração & dosagem
3.
Int J Sport Nutr Exerc Metab ; 34(4): 199-206, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38458180

RESUMO

Carbohydrate (CHO) supplementation during endurance exercise can improve performance. However, it is unclear whether low glycemic index (GI) CHO leads to differential ergogenic and metabolic effects compared with a standard high GI CHO. This study investigated the ergogenic and metabolic effects of CHO supplementation with distinct GIs, namely, (a) trehalose (30 g/hr), (b) isomaltulose (30 g/hr), (c) maltodextrin (60 g/hr), and (d) placebo (water). In this double-blind, crossover, counterbalanced, placebo-controlled study, 13 male cyclists cycled a total of 100 min at varied exercise intensity (i.e., 10-min stages at 1.5, 2.0, and 2.5 W/kg; repeated three times plus two 5-min stages at 1.0 W/kg before and after the protocol), followed by a 20-min time trial on four separated occasions. Blood glucose and lactate (every 20 min), heart rate, and ratings of perceived exertion were collected throughout, and muscle biopsies were taken before and immediately after exercise. The results showed that trehalose improved time-trial performance compared with placebo (total work done 302 ± 39 vs. 287 ± 48 kJ; p = .01), with no other differences between sessions (all p ≥ .07). Throughout the 100-min protocol, blood glucose was higher with maltodextrin compared with the other supplements at all time points (all p < .05). Heart rate, ratings of perceived exertion, muscle glycogen content, blood glucose, and lactate were not different between conditions when considering the 20-min time trial (all p > .05). Trehalose supplementation throughout endurance exercise improved cycling performance and appears to be an appropriate CHO source for exercise tasks up to 2 hr. No ergogenic superiority between the different types of CHO was established.


Assuntos
Desempenho Atlético , Ciclismo , Glicemia , Estudos Cross-Over , Frequência Cardíaca , Isomaltose , Ácido Láctico , Polissacarídeos , Trealose , Humanos , Masculino , Ciclismo/fisiologia , Método Duplo-Cego , Trealose/administração & dosagem , Trealose/farmacologia , Desempenho Atlético/fisiologia , Adulto , Glicemia/metabolismo , Glicemia/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Ácido Láctico/sangue , Polissacarídeos/administração & dosagem , Polissacarídeos/farmacologia , Isomaltose/análogos & derivados , Isomaltose/administração & dosagem , Isomaltose/farmacologia , Suplementos Nutricionais , Índice Glicêmico , Resistência Física/efeitos dos fármacos , Resistência Física/fisiologia , Músculo Esquelético/efeitos dos fármacos , Músculo Esquelético/metabolismo , Fenômenos Fisiológicos da Nutrição Esportiva , Substâncias para Melhoria do Desempenho/administração & dosagem , Substâncias para Melhoria do Desempenho/farmacologia , Carboidratos da Dieta/administração & dosagem , Adulto Jovem , Esforço Físico/fisiologia , Esforço Físico/efeitos dos fármacos , Glicogênio/metabolismo
4.
Crit Rev Food Sci Nutr ; 63(3): 438-446, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-34275371

RESUMO

The aim of this study was to perform a systematic review on the effects of caffeine mouth rinsing on physical and cognitive performance. Following a search through 4 databases, 18 studies were found meeting the inclusion criteria (15 for physical performance and 3 for cognitive performance). All selected studies found an improvement in cognitive performance with caffeine mouth rinse. Four studies found positive effects of caffeine mouthwash on physical performance when repeated during exercise, while one study detected a positive effect with a single mouthwash before exercise, but only in a fasted state. Among these studies that showed positive effects, however, three (2 for physical performance and 1 for cognitive performance) presented fair methodological quality. There was also a variety of methodological approaches in the studies that showed no improvement in physical performance with caffeine mouth rinse, which may have influenced the potential to detect the ergogenic effect of caffeine mouth rinse. Thus, the effects of caffeine mouth rinse on physical performance are mixed, but a potential ergogenic effect might be present in a fasted state and when mouthwash is repeated during exercise. Concerning cognitive performance, caffeine mouth rinse seems to be a beneficial strategy.


Assuntos
Desempenho Atlético , Substâncias para Melhoria do Desempenho , Cafeína/farmacologia , Antissépticos Bucais/farmacologia , Substâncias para Melhoria do Desempenho/farmacologia , Cognição
5.
Eur J Sport Sci ; 23(5): 714-725, 2023 May.
Artigo em Inglês | MEDLINE | ID: mdl-35239468

RESUMO

The aim of this systematic review with meta-analysis was to determine the effect of caffeine gum (Caff-gum) on exercise performance-related outcomes. Several databases were searched for studies assessing the effect of Caff-gum in placebo-controlled protocols involving healthy adults. Random-effects meta-analyses using standardized mean differences (SMD) were performed to determine the effect of Caff-gum on exercise outcomes with several sub-analyses (training status, exercise type, timing and dose) for potential modifying factors. 14 studies were included, totalling 200 participants. There was a significant overall effect of Caff-gum compared to placebo (SMD = 0.21, 95%CI: 0.10-0.32; p = 0.001). Subgroup analysis showed improved performance for trained (SMD = 0.23, 95%CI: 0.08-0.37; p = 0.004), but not for untrained (SMD = 0.14, 95%CI: -0.02-0.29; p = 0.07) individuals. Caff-gum improved both endurance (SMD = 0.27, 95%CI: 0.12-0.42; p = 0.002) and strength/power (SMD = 0.20, 95%CI: 0.03-0.37; p = 0.03) performance outcomes. Caff-gum was ergogenic when consumed within 15 min prior to initiating exercise (SMD = 0.27, 95%CI: 0.07-0.4; p = 0.01), but not when provided >15 min prior (SMD = -0.48, 95%CI = -1.7-0.82; p = 0.25). There was no significant effect of Caff-gum with doses <3 mg/kg body mass (BM) (SMD = 0.20, 95%CI: -0.03-0.43; p = 0.07), but there was a significant effect when the dose was ≥3 mg/kg BM (SMD = 0.22, 95%CI: 0.07-0.37; p = 0.01). Caff-gum supplementation may be an effective ergogenic strategy for trained athletes involved in both endurance and strength/power exercise, using a recommended dose of ≥3 mg/kg BM consumed within 15 min of initiating exercise.HighlightsThis study determined the effect of Caff-gum on exercise performance, using a systematic review and meta-analysis. Fourteen studies, totalling 200 participants performing a variety of endurance and strength/power exercise tests were included. The relative Caff-gum dose ranged from 1.27-4.26 mg/kg BM and timing ranged from 120 min prior to exercise up to intra-test application.Caff-gum was shown to be an effective ergogenic aid for trained individuals involved in both endurance and strength/power exercise.Supplement dose and timing modified the efficacy of Caff-gum. Supplementation with Caff-gum was effective when provided in doses ≥3 mg/kg BM and within 15 min prior to initiating exercise.Trained endurance or strength/power athletes seeking to benefit from caffeine in the form of chewing gum should supplement within 15 min prior to initiating an exercise task, in doses ≥3 mg/kg BM.


Assuntos
Cafeína , Substâncias para Melhoria do Desempenho , Adulto , Humanos , Cafeína/farmacologia , Goma de Mascar , Exercício Físico , Teste de Esforço , Substâncias para Melhoria do Desempenho/farmacologia , Suplementos Nutricionais
6.
Eur J Appl Physiol ; 122(8): 1915-1928, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35612684

RESUMO

PURPOSE: Caffeine improves cycling time trial (TT) performance; however, it is unknown whether caffeine is ergogenic when competing against other riders. The aim of this study was to investigate whether caffeine improves performance during a 4-km cycling TT when riding against a virtual opponent, and whether it is associated with increased muscle activation and at the expense of greater end-exercise central and peripheral fatigue. METHODS: Using a randomized, crossover, and double-blind design, eleven well-trained cyclists completed a 4-km cycling TT alone without supplementation (CON), or against a virtual opponent after ingestion of placebo (OP-PLA) or caffeine (5 mg.kg-1, OP-CAF). Central and peripheral fatigue were quantified via the pre- to post-exercise decrease in voluntary activation and potentiated twitch force, respectively. Muscle activation was continually measured during the trial via electromyography activity. RESULTS: Compared to CON, OP-PLA improved 4-km cycling TT performance (P = 0.018), and OP-CAF further improved performance when compared to OP-PLA (P = 0.050). Muscle activation was higher in OP-PLA and OP-CAF than in CON throughout the trial (P = 0.003). The pre- to post-exercise reductions in voluntary activation and potentiated twitch force were, however, similar between experimental conditions (P > 0.05). Compared to CON, OP-PLA increased the rating of perceived exertion during the first 2 km, but caffeine blunted this increase with no difference between the OP-CAF and CON conditions. CONCLUSIONS: Caffeine is ergogenic when riding against a virtual opponent, but this is not due to greater muscle activation or at the expense of greater end-exercise central or peripheral fatigue.


Assuntos
Desempenho Atlético , Substâncias para Melhoria do Desempenho , Desempenho Atlético/fisiologia , Ciclismo/fisiologia , Cafeína/farmacologia , Estudos Cross-Over , Método Duplo-Cego , Ingestão de Alimentos , Humanos , Masculino , Fadiga Muscular , Substâncias para Melhoria do Desempenho/farmacologia , Poliésteres
7.
Sports Med ; 52(9): 2209-2220, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35536449

RESUMO

OBJECTIVE: The aim was to quantify the proportion of the literature on caffeine supplementation that reports habitual caffeine consumption, and determine the influence of habitual consumption on the acute exercise response to caffeine supplementation, using a systematic review and meta-analytic approach. METHODS: Three databases were searched, and articles screened according to inclusion/exclusion criteria. Three-level meta-analyses and meta-regression models were used to investigate the influence of habitual caffeine consumption on caffeine's overall ergogenic effect and within different exercise types (endurance, power, strength), in men and women, and in trained and untrained individuals. Sub-analyses were performed according to the following: acute relative dose (< 3, 3-6, > 6 mg/kg body mass [BM]); whether the acute caffeine dose provided was lower or higher than the mean daily caffeine dose; and the caffeine withdrawal period prior to the intervention (< 24, 24-48, > 48 h). RESULTS: Sixty caffeine studies included sufficient information on habitual consumption to be included in the meta-analysis. A positive overall effect of caffeine was shown in comparison to placebo (standard mean difference [SMD] = 0.25, 95% confidence interval [CI] 0.20-0.30; p < 0.001) with no influence of relative habitual caffeine consumption (p = 0.59). Subgroup analyses showed a significant ergogenic effect when the caffeine dose was < 3 mg/kg BM (SMD = 0.26, 95% CI 0.12-0.40; p = 0.003) and 3-6 mg/kg BM (SMD = 0.26, 95% CI 0.21-0.32; p < 0.0001), but not > 6 mg/kg BM (SMD = 0.11, 95% CI - 0.07 to 0.30; p = 0.23); when the dose was both higher (SMD = 0.26, 95% CI 0.20-0.31; p < 0.001) and lower (SMD = 0.21, 95% CI 0.06-0.36; p = 0.006) than the habitual caffeine dose; and when withdrawal was < 24 h, 24-48 h, and > 48 h. Caffeine was effective for endurance, power, and strength exercise, with no influence (all p ≥ 0.23) of relative habitual caffeine consumption within exercise types. Habitual caffeine consumption did not modify the ergogenic effect of caffeine in male, female, trained or untrained individuals. CONCLUSION: Habitual caffeine consumption does not appear to influence the acute ergogenic effect of caffeine.


Assuntos
Substâncias para Melhoria do Desempenho , Cafeína/farmacologia , Café , Exercício Físico/fisiologia , Feminino , Humanos , Masculino , Substâncias para Melhoria do Desempenho/farmacologia
8.
Curr Nutr Rep ; 11(2): 273-282, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35394616

RESUMO

PURPOSE OF REVIEW: To verify the effects of sodium bicarbonate (NaHCO3) supplementation on biochemical and physical measurements of combat sports athletes. RECENT FINDINGS: A systematic review of articles indexed in three databases (PubMed, CAPES journal, and Google Scholar) was carried out until October 2020, using descriptors related to NaHCO3 supplementation in combat sports. First, 38 articles were identified. Next, eight articles were selected through the inclusion and exclusion criteria. The methodological quality of the articles was assessed using the Physiotherapy Evidence Database (PEDro) scale (8 and 9 points). Blood lactate, rating of perceived exertion, Special Judo Fitness Test, Dummy throw, and mean and peak powers for Wingate were evaluated. Random effects meta-analysis was used, the effect size was adjusted by corrected Hedges' g, and the heterogeneity is explored by I2. The results were obtained through weighted average and 95% CI, and the significance limit was set as p < 0.05. NaHCO3 supplementation had a significant effect on increasing blood lactate (p = 0.006) of the athletes studied. However, the performance measures (rating of perceived exertion, power, and specific performance) did not show a significant difference (p ˂ 0.05). In conclusion, NaHCO3 supplementation causes a significant increase in blood lactate, indicating an ergogenic effect on buffer, which can delay the onset of fatigue and contribute to the performance of combat sports athletes. New experimental studies need to be published that assess the effect of acute and chronic NaHCO3 supplementation in specific combat sports tests and in women.


Assuntos
Desempenho Atlético , Substâncias para Melhoria do Desempenho , Suplementos Nutricionais , Feminino , Humanos , Lactatos , Substâncias para Melhoria do Desempenho/farmacologia , Bicarbonato de Sódio/farmacologia
9.
J Strength Cond Res ; 36(7): 1901-1908, 2022 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-32796413

RESUMO

ABSTRACT: Molina Correa, JC, Padoin, S, Varoni, PR, Demarchi, MC, Flores, LJ, Nampo, FK, and de Paula Ramos, S. Ergogenic effects of photobiomodulation on performance in the 30-second Wingate test: A randomized, double-blind, placebo-controlled, crossover study. J Strength Cond Res 36(7): 1901-1908, 2022-The purpose of this study was to evaluate the ergogenic effects of red light (630 nm) photobiomodulation on anaerobic capacity in the Wingate test. Sixteen healthy and physically active male volunteers (21.71 ± 2.49 years of age, body mass index between 18.5 and 24.9 kg/m2) participated in this randomized, double-blind, placebo-controlled, crossover study. The subjects performed 3 Wingate test sessions, with a 48-hour interval between tests. In the first session (baseline session, BS), a Wingate test was performed to evaluate the initial performance. Subjects were paired by performance in the BS and allocated through a draw to receive either the phototherapy (630 nm, 4.6 J/cm2, 6 J per point, 16 points, light-emitting diode [LED] session) or placebo intervention (PLA session) in the second test session. In the third test session, a crossover intervention was performed. The repeated-measures analysis of variance test, followed by Bonferroni post hoc test or Friedman test with Dunn's post hoc test (p < 0.05) and Cohen's d statistic were used for comparisons. The LED session with phototherapy promoted an increase in performance in peak power (p < 0.05), relative power (p < 0.05), RPMpeak (p < 0.05), and peak velocity (p < 0.05), as well as total displacement (p < 0.01) compared with PLA. The mean power (p < 0.05), relative power (p < 0.05), RPMmean (p < 0.01), and mean velocity (p < 0.01) were higher in the LED session than those of BS. We concluded that phototherapy improves performance in Wingate anaerobic exercise, possibly due to large effects on the anaerobic alactic metabolism.


Assuntos
Substâncias para Melhoria do Desempenho , Estudos Cross-Over , Método Duplo-Cego , Humanos , Masculino , Substâncias para Melhoria do Desempenho/farmacologia , Poliésteres , Adulto Jovem
10.
Sports Med ; 52(3): 505-526, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34687438

RESUMO

BACKGROUND: Extracellular buffering supplements [sodium bicarbonate (SB), sodium citrate (SC), sodium/calcium lactate (SL/CL)] are ergogenic supplements, although questions remain about factors which may modify their effect. OBJECTIVE: To quantify the main effect of extracellular buffering agents on exercise outcomes, and to investigate the influence of potential moderators on this effect using a systematic review and meta-analytic approach. METHODS: This study was designed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Three databases were searched for articles that were screened according to inclusion/exclusion criteria. Bayesian hierarchical meta-analysis and meta-regression models were used to investigate pooled effects of supplementation and moderating effects of a range of factors on exercise and biomarker responses. RESULTS: 189 articles with 2019 participants were included, 158 involving SB supplementation, 30 with SC, and seven with CL/SL; four studies provided a combination of buffering supplements together. Supplementation led to a mean estimated increase in blood bicarbonate of + 5.2 mmol L-1 (95% credible interval (CrI) 4.7-5.7). The meta-analysis models identified a positive overall effect of supplementation on exercise capacity and performance compared to placebo [ES0.5 = 0.17 (95% CrI 0.12-0.21)] with potential moderating effects of exercise type and duration, training status and when the exercise test was performed following prior exercise. The greatest ergogenic effects were shown for exercise durations of 0.5-10 min [ES0.5 = 0.18 (0.13-0.24)] and > 10 min [ES0.5 = 0.22 (0.10-0.33)]. Evidence of greater effects on exercise were obtained when blood bicarbonate increases were medium (4-6 mmol L-1) and large (> 6 mmol L-1) compared with small (≤ 4 mmol L-1) [ßSmall:Medium = 0.16 (95% CrI 0.02-0.32), ßSmall:Large = 0.13 (95% CrI - 0.03 to 0.29)]. SB (192 outcomes) was more effective for performance compared to SC (39 outcomes) [ßSC:SB = 0.10 (95% CrI - 0.02 to 0.22)]. CONCLUSIONS: Extracellular buffering supplements generate large increases in blood bicarbonate concentration leading to positive overall effects on exercise, with sodium bicarbonate being most effective. Evidence for several group-level moderating factors were identified. These data can guide an athlete's decision as to whether supplementation with buffering agents might be beneficial for their specific aims.


Assuntos
Tolerância ao Exercício , Substâncias para Melhoria do Desempenho , Teorema de Bayes , Suplementos Nutricionais , Humanos , Substâncias para Melhoria do Desempenho/farmacologia , Bicarbonato de Sódio/farmacologia
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