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OBJECTIVE: To understand the burden of acute rheumatic fever (ARF) among children living in low-income countries who present to the hospital with febrile illness and to determine the role of handheld echocardiography (HHE) in uncovering subclinical carditis as a major manifestation of ARF. STUDY DESIGN: This was a cross-sectional study carried at the Pediatric Hospital in Al Obeid, North Kordofan, Sudan, from September 2022 to January 2023 and including febrile children 3 through 18 years of age with or without clinical features of ARF and without another cause for their fever (not excluding malaria). History, examination, blood investigations, and HHE were done. ARF was diagnosed according to the Jones criteria. Clinical ARF was diagnosed if there was a major clinical Jones criterion and silent ARF if the only major Jones criteria was subclinical carditis. RESULTS: The study cohort included 400 children with a mean age of 9 years. Clinical ARF was diagnosed in 95 patients (95/400, 24%), most of whom presented with a joint major manifestation (88/95, 93%). Among the 281 children who did not present with a clinical manifestation of ARF, HHE revealed rheumatic heart disease (RHD) in 44 patients (44/281, 16%); 31 of them fulfilled criteria for silent ARF (31/281, 11%). HHE increased the detection of ARF by 24%. HHE revealed mild RHD in 41 of 66 (62%) and moderate or severe RHD in 25 of 66 (38%) patients. Both sensitivity and specificity of HHE compared with standard echocardiography were 88%. CONCLUSIONS: There is a significant burden of ARF among febrile children in Sudan. HHE increased the sensitivity of diagnosis, with 11% of children having subclinical carditis as their only major manifestation (ie, silent ARF). RHD-prevention policies need to prioritize decentralization of echocardiography to improve ARF detection.
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Ecocardiografia , Febre Reumática , Cardiopatia Reumática , Humanos , Criança , Estudos Transversais , Masculino , Feminino , Cardiopatia Reumática/epidemiologia , Cardiopatia Reumática/diagnóstico por imagem , Febre Reumática/complicações , Febre Reumática/diagnóstico por imagem , Pré-Escolar , Ecocardiografia/métodos , Sudão , Adolescente , Febre/etiologia , Doenças EndêmicasRESUMO
Aim: Correct orientation of the occlusal plane plays a vital role in achieving the perfect occlusal balance and function of complete dentures. This study aimed to evaluate the most reliable posterior reference point of the ala-tragus line (ATL) concerning occlusal plane (OP) in a sample of the dentate Sudanese population. Materials and Methods: A total of 150 subjects with healthy and well-aligned permanent teeth were randomly selected. Right lateral profile photographs were taken with subjects having a fox plane placed intra-orally, contacting the occlusal plane. Reference points corresponding to inferior, middle, and superior borders of the tragus and inferior border of the ala of the nose were marked on photographs. The angles between the lines were measured using the Auto-CAD software program, and the most parallel relationship was determined. Descriptive statistics in terms of means and standard deviations were presented. Independent t-test and one-way ANOVA tests were used to compare as appropriate. A p-value < 0.05 was considered significant. Results: The mean angle formed by the OP and ATL was 8.5±3.69º for the superior level, 4.68±3.13º for the middle line, and 2.89±2.57º for the inferior line. A significant difference was found between the means of the three angles (p< 0.001), while no significant difference (p> 0.05) was found between both genders regarding the measured angles. Conclusions: The line joining the inferior border of the ala of the nose with the inferior border of the tragus of the ear was the most reliable line in terms of parallelism to determine the occlusal plane orientation.
Antecedentes: La orientación correcta del plano oclusal juega un papel vital para lograr el equilibrio oclusal perfecto y la función de las prótesis completas. Este estudio tuvo como objetivo evaluar el punto de referencia posterior más confiable de la línea ala-trago (ATL) con respecto al plano oclusal (OP) en una muestra de la población dentada de Sudán. Materiales y Métodos: Se seleccionaron aleatoriamente un total de 150 sujetos con dientes permanentes sanos y bien alineados. Se tomaron fotografías de perfil lateral derecho de sujetos a los que se les colocó un plano de zorro intraoralmente, en contacto con el plano oclusal. En las fotografías se marcaron los puntos de referencia correspondientes a los bordes inferior, medio y superior del trago y al borde inferior del ala de la nariz. Los ángulos entre las líneas se midieron utilizando el programa de software Auto-CAD y se determinó la relación más paralela. Se presentaron estadísticas descriptivas en términos de medias y desviaciones estándar. Se utilizaron prueba-t independiente y prueba ANOVA unidireccional para las comparaciones, según correspondiera. Se consideró significativo un valor de p<0,05. Resultados: El ángulo medio formado por OP y ATL fue de 8,5±3,69º para el nivel superior, 4,68±3,13º para la línea media y 2,89±2,57º para la línea inferior. Se encontró una diferencia significativa entre las medias de los tres ángulos (p< 0,001), mientras que no se encontró diferencia significativa (p>0,05) entre ambos sexos con respecto a los ángulos medidos. Conclusión: La línea que une el borde inferior del ala de la nariz con el borde inferior del trago de la oreja fue la línea más confiable en términos de paralelismo para determinar la orientación del plano oclusal.
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Masculino , Feminino , Adolescente , Adulto , Adulto Jovem , Pontos de Referência Anatômicos , Prostodontia , Sudão , Cefalometria , Estudos Transversais , Prótese TotalRESUMO
Abstract Introduction: Sudan is the third largest country in Africa and has rich reserves of petroleum and other ground resources, but its per capita Gross Domestic Product is only $808 and researchers work in insufficient institutional facilities and with little funding. Previous studies about its scientific productivity have been limited to specific subjects and relatively short periods, with no large analyses until now. Objective: To analyze the scientific output of Sudan in depth, considering all research areas and several decades of scientific activity. Methods: We retrieved the documents with "Sudan" in field country in the Science Citation Index Expanded for the period 1900-2019. Results: We retrieved over 9 000 publications and found that most were articles; that citation was higher for review articles and book chapters, and that this index mostly covered articles in English. Beginning in 1972, the number of publications in this database has increased rapidly. The citation lifespan indicates slow growth in the Sudanese scientific literature, and collaboration is frequent both nationally and internationally, possibly because the scarce resources make collaboration almost compulsory. Most external collaboration is done with Saudi Arabia but citation is higher for articles resulting from international megaprojects, led by Europe and the USA, in which Sudanese researchers play secondary roles. Research focusses on applied technological subjects with little innovation value. Women play a smaller role in Sudanese science. Conclusions: Our recommendations for Sudanese science include increasing the number of women in leading research positions; providing funding directly to researchers (i.e., bypassing bureaucratic bodies); increasing basic research to avoid stagnation; training Sudanese researchers for leading positions; and identifying specific research areas where Sudan can lead in its region.
Resumen Introducción: Sudán es el tercer país más grande de África y tiene ricas reservas de petróleo y otros recursos terrestres, pero su Producto Interno Bruto per cápita es de solo $ 808 y los investigadores trabajan en instalaciones institucionales deficientes y con poca financiación. Los estudios previos sobre su productividad científica se han limitado a temas específicos y períodos relativamente cortos. Objetivo: Analizar la producción científica de Sudán en profundidad, considerando todas las áreas de investigación y varias décadas. Métodos: Recuperamos los documentos con "Sudán" como país de origen en el Science Citation Index Expanded para el período 1900-2019. Resultados: Hallamos más de 9 000 publicaciones y encontramos que la mayoría eran artículos; que fueron más citados los artículos de revisión y capítulos de libros, y que esta base de datos cubría principalmente artículos en inglés; desde 1972, el número de publicaciones en ella ha aumentado rápidamente. La vida útil de las citas indica un crecimiento lento en la literatura científica sudanesa, y la colaboración es frecuente tanto a nivel nacional como internacional, posiblemente porque los escasos recursos hacen que la colaboración sea casi obligatoria. La mayor parte de la colaboración externa se realiza con Arabia Saudita, pero hay más citas para los artículos resultantes de megaproyectos internacionales, dirigidos por Europa y Estados Unidos, en los cuales los investigadores sudaneses desempeñan papeles secundarios. La investigación se centra en temas de tecnología aplicada con poco valor de innovación. Conclusiones: Nuestras recomendaciones para la ciencia sudanesa incluyen aumentar el número de mujeres en altos puestos; proporcionar financiación directamente a los investigadores (sin pasar por organismos burocráticos); ir más allá de la investigación aplicada para evitar el estancamiento; capacitar al personal sudanés para puestos de liderazgo; e identificar áreas de investigación específicas donde Sudán puede liderar en su región.
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Pesquisa , Bibliometria , Sudão , BibliometriaRESUMO
Aim: This study aimed to evaluate the correlation between vertical dimension of occlusion (VDO) and various facial measurements in a sample of Sudanese adults. Material and Methods: A total of 113 dental students (33 males and 80 females) with a mean age of 21.7±1.26 years were enrolled in this study. Different facial measurements including (Eye-Mouth, Eye-Eye, Eye-Ear, and Ear Height) were compared with two different measurements of VDO: N-Gn (from the tip of the nose to the tip of the chin), and Sn-Me (from the base of the nose to the bottom of the chin). Pearson's correlation coefficient test was utilized for the correlation between the measured parameters. A p-value of less than 0.05 was considered significant for all analyses. Results: A significant positive correlation was shown between all measured facial distances and both measured VDO distances. Though, the strongest correlation was seen for the eye-mouth distance (r= 0.725, p<0.001), while the weakest was for ear height (r= 0.254, p= 0.007). A paired t-test revealed a significant longer N-Gn distance than Sn-Me distance. Also, it has been shown that there were no significant differences between right and left sides of the face. Conclusion: The distance measured from the outer canthus of the eye to the angle of the mouth can be used to predict Subnasale-Menton (Sn-Me) distance.
Objetivo: Este estudio tuvo como objetivo evaluar la correlación entre dimensión vertical oclusal (DVO) y varias medidas faciales en una muestra de adultos sudaneses. Material y Métodos: Un total de 113 estudiantes de odontología (33 hombres y 80 mujeres) con una edad media de 21,7 ± 1,26 años se inscribieron en este estudio. Se compararon diferentes medidas faciales que incluyen (ojo- boca, ojo-ojo, ojo-oído y altura de la oreja) con dos medidas diferentes de DVO: N-Gn (desde la punta de la nariz hasta la punta del mentón) y Sn -Yo (desde la base de la nariz hasta la parte inferior del mentón). Se utilizó la prueba del coeficiente de correlación de Pearson para la correlación entre los parámetros medidos. Un valor de p inferior a 0,05 se consideró significativo para todos los análisis. Resultados: Se mostró una correlación positiva significativa entre todas las distancias faciales medidas y ambas distancias DVO medidas. Sin embargo, la correlación más fuerte se observó para la distancia ojo-boca (r=0,725, p<0,001), mientras que la más débil fue para la altura de las orejas (r=0,254, p=0,007). Una prueba de t pareada reveló una distancia N-Gn significativamente más larga que la distancia subnasal-mentón. Además, se ha demostrado que no hubo diferencias significativas entre los lados derecho e izquierdo de la cara. Conclusión: La distancia medida desde el canto externo del ojo hasta el ángulo de la boca puede utilizarse para predecir la distancia subnasal-mentón.
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Humanos , Masculino , Feminino , Dimensão Vertical , Face/anatomia & histologia , Prostodontia , Sudão/epidemiologia , Antropometria , Nariz/anatomia & histologia , Queixo/anatomia & histologia , Oclusão Dentária , Olho/anatomia & histologia , Desenvolvimento Maxilofacial , Boca/anatomia & histologiaRESUMO
SUMMARY: The ongoing advances in the technology of coronary artery angiograms have put high demands on the basic knowledge of coronary arteries. This study describes the angiographic morphology of the ostium (orifice) of the left coronary artery among Sudanese with respect to sex, age, length, and BMI. The study design is a cross-sectional retrospective hospital-based conducted from 2014 to 2016. The inclusion criterion of participants is adult males and females presented to the cardiac centers for elective angiograms. The exclusion criteria are age below 18 years, documented congenital heart disease, and previous coronary bypass. Angiograms were done using a digital radiographic system. Data was collected through a predesigned data collection sheet. The data were entered and analyzed using SPSS v27. A test of correlation was done between the different variables. The data were presented in the form of tables. A P-value of <0.05 was considered statistically significant. The total number of participants was 441; males and females represent 42.9 % and 57,1 %, respectively. The mean age of participants was 56.24±8.68 years. The left coronary artery originated from the left aortic sinus. The mean diameter and length of the left coronary artery were 3.8±0.70 mm and 8.1576±4.32 mm, respectively. A significant negative correlation was reported between the diameter of the orifice and both age and length of the left coronary artery. A non-significant difference between males and females in the diameter of the left coronary artery at ostium (P=0.058) and a significant difference in the length (P=0.00). Sudanese have the smallest diameter of the orifice of the left coronary artery among Africans. Sudanese males have a smaller diameter of orifice than females; females have the longest arteries. A wider orifice of the left coronary artery is associated with a short arterial length.
RESUMEN: Los avances en la tecnología de los angiogramas de las arterias coronarias constituyen importantes exigencias al conocimiento básico de las arterias coronarias. Este estudio describe la morfología angiográfica del ostio de la arteria coronaria izquierda (ACI) entre los sudaneses respecto al sexo, la edad, la longitud y el IMC. El estudio es un diseño hospitalario retrospectivo transversal realizado entre 2014 y 2016. El criterio de inclusión de los participantes, hombres y mujeres adultos, fue aquellos que se realizaron angiografías electivas en los centros cardiológicos Los criterios de exclusión fueron: edad menor de 18 años, cardiopatía congénita documentada y bypass coronario previo. Los angiogramas se realizaron utilizando un sistema radiográfico digital. Los datos se obtuvieron a través de una ficha de datos prediseñada. Estos fueron ingresados y analizados con SPSS v27. Se realizó una prueba de correlación entre las diferentes variables. Los datos se presentaron en forma de tablas. Un valor P de <0,05 se consideró estadísticamente significativo. El número total de participantes fue de 441; Hombres y mujeres representanron el 42,9 % y 57,1 %, respectivamente. La edad media de los participantes fue de 56,24±8,68 años. La arteria coronaria izquierda se originaba en el seno aórtico izquierdo. El diámetro medio y la longitud de la arteria coronaria izquierda fueron 3,8±0,70 mm y 8,1576±4,32 mm, respectivamente. Se encontró una correlación negativa significativa entre el diámetro del ostio, la edad y la ACI. Además se encontró una diferencia no significativa entre hombres y mujeres en el diámetro del ostio de la ACI (P=0,058) y una diferencia significativa en la longitud (P=0,00). Los sudaneses tienen el diámetro del ostio de la arteria coronaria izquierda más pequeño entre los africanos. Los hombres sudaneses tienen un diámetro del ostio de la arteria coronaria izquierda más pequeña y las mujeres tienen las arterias más largas. Un ostio más ancho de la arteria coronaria izquierda se asocia con una longitud arterial corta.
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Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Vasos Coronários/diagnóstico por imagem , Sudão , Angiografia , Estudos Transversais , Estudos Retrospectivos , Vasos Coronários/anatomia & histologiaRESUMO
INTRODUCTION: Colombian-haired sheep (OPC) is a creole breed with very good adaptation to the tropical conditions of our country. In sheep, it has been shown that the litter size (LS) is associated with ovulation rate, the number of fertilized eggs, and embryo survival. Also, LS is determined by genetic and environmental effects. In this sense, the receptor 1B of bone morphogenetic protein (BMPR-1B) has been described as a genetic factor. Therefore, the aim of the present work was to characterize and associate the SNP C864T in the BMPR-1B gene with LS in the specific OPC biotypes Ethiopian and Sudan. MATERIALS AND METHODS: Reproductive history (LS, number of calving in the mother, identification of the father, conception year, and conception period) of 200 OPC sheep was assessed. Additionally, sheep were genotyped by sequencing for the SNP C864T. An association between LS, reproductive history, and C864T variation was performed using a GLM fixed-effect model. RESULTS: The frequency of the T allele (0.75 ± 0.03) was higher than that of the C allele (P<0.05). The genotypic frequencies were 0.55 ± 0.06, 0.38 ± 0.04, and 0.07 ± 0.01, for TT, TC, and CC, respectively. An average value of He (0.37 ± 0.03) and HWE (P=0.97) was found. The LS found was 1.45 ± 0.15. This varied, between biotypes, with number of calving in the mother, with the father, and at the time of conception (P <0.05). CONCLUSION: The LS varied between genotypes (P<0.05). The CC genotype was the most prolific (1.81 ± 0.4), followed by the heterozygous (1.45 ± 0.04) and the TT homozygous (1.09 ± 0.04). However, we did not find a variation between biotypes within the genotypes (P>0.05). In conclusion, the polymorphism target in the exon 9 of the BMPR-1B gene and non-genetic factors affected significantly the litter size in the OPC.
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Receptores de Proteínas Morfogenéticas Ósseas Tipo I/genética , Polimorfismo Genético , Ovinos/classificação , Ovinos/genética , Animais , Cruzamento , Colômbia , Etiópia , Feminino , Genótipo , Tamanho da Ninhada de Vivíparos/genética , Masculino , Gravidez , História Reprodutiva , SudãoRESUMO
OBJECTIVES: Natural disasters (NDs) may increase the outbreaks and transmissions of vector-borne diseases such as cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). However, the relationship between leishmaniases and NDs has not yet been clearly established. Here, we systematically reviewed all reported articles in this field to answer whether NDs increase the frequency of leishmaniases. METHODS: All the related articles published during January 2000 till January 2020 were reviewed. Moreover, all NDs and the associated leishmaniases frequencies reports in 17 leishmaniases endemic countries were searched to find any ND-leishmaniases relationship. RESULTS: After the initial screening, 39 articles on ND-leishmaniases were selected and systematically reviewed. These articles showed different frequencies of CL in the endemic areas before and after NDs in some regions of Pakistan and Iran and in case of VL in Brazil, Ethiopia, and Sudan. After thorough deliberation, four studies for CL-ND and five studies for VL-ND relationships were selected for meta-analysis. The results showed increases in the leishmaniases incidences after NDs, although not robustly. CONCLUSION: The lack of a strong leishmaniases-ND relationship could be attributed to the local compilations of such data in scattered regions of the endemic countries. Therefore, currently a substantial knowledge gap on leishmaniases-ND relationship is apparent.
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Leishmaniose Cutânea/epidemiologia , Leishmaniose Visceral/epidemiologia , Desastres Naturais , Brasil/epidemiologia , Surtos de Doenças , Etiópia/epidemiologia , Saúde Global , Humanos , Incidência , Irã (Geográfico)/epidemiologia , Paquistão/epidemiologia , Fatores de Risco , Sudão/epidemiologiaRESUMO
Tracking the history of the discovery of mycetoma is not simple because identifying the roots of medical knowledge depends on utilising sources that employ imprecise and sometimes confusing descriptions when compared with those based on modern medical terminology. Ancient sources of information include writings, such as poetry, archaeology and paleopathology, as well as legend and folklore. The earliest precise descriptions of mycetoma were recorded in the mid-19th century by medical officers working in southern India. But interest in the disease spread rapidly both among doctors in India and elsewhere, from Algeria to Mexico to Sudan. Although over time the names of organisms have changed, the clinical and pathological descriptions still stand as testament to those early detailed studies. Some of the conclusions of the early investigators, particularly the general lack of effective treatment and the difficulty in diagnosis, remain true today.
Assuntos
Micetoma , Médicos , História do Século XIX , História do Século XX , História Antiga , Humanos , Índia , México , Micetoma/diagnóstico , SudãoRESUMO
Mycetoma is a localized, chronic, granulomatous disease that can be caused by fungi (eumycetoma) or bacteria (actinomycetoma). Of the 70 different causative agents implicated in mycetoma worldwide, Actinomadura madurae is the only one that causes multiple cases on all continents. Recently, new Actinomadura species were described as causative agents of human mycetoma. One of these new causative agents was Actinomadura mexicana, which was identified in Latin America. Here we demonstrate that this causative agent is not confined to Latin America and that it is also a causative agent of actinomycetoma in Sudan. The disease was managed by antibiotic treatment alone and resulted in complete cure after 6 months of treatment, which is quick when compared with actinomycetoma cases caused by other Actinomadura species.
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Micetoma , Actinomadura , Antibacterianos/uso terapêutico , Humanos , Micetoma/tratamento farmacológico , Micetoma/epidemiologia , Sudão/epidemiologiaRESUMO
BACKGROUND: The United States Department of Agriculture (USDA) National Plant Germplasm System (NPGS) sorghum core collection contains 3011 accessions randomly selected from 77 countries. Genomic and phenotypic characterization of this core collection is necessary to encourage and facilitate its utilization in breeding programs and to improve conservation efforts. In this study, we examined the genome sequences of 318 accessions belonging to the NPGS Sudan sorghum core set, and characterized their agronomic traits and anthracnose resistance response. RESULTS: We identified 183,144 single nucleotide polymorphisms (SNPs) located within or in proximity of 25,124 annotated genes using the genotyping-by-sequencing (GBS) approach. The core collection was genetically highly diverse, with an average pairwise genetic distance of 0.76 among accessions. Population structure and cluster analysis revealed five ancestral populations within the Sudan core set, with moderate to high level of genetic differentiation. In total, 171 accessions (54%) were assigned to one of these populations, which covered 96% of the total genomic variation. Genome scan based on Tajima's D values revealed two populations under balancing selection. Phenotypic analysis showed differences in agronomic traits among the populations, suggesting that these populations belong to different ecogeographical regions. A total of 55 accessions were resistant to anthracnose; these accessions could represent multiple resistance sources. Genome-wide association study based on fixed and random model Circulating Probability (farmCPU) identified genomic regions associated with plant height, flowering time, panicle length and diameter, and anthracnose resistance response. Integrated analysis of the Sudan core set and sorghum association panel indicated that a large portion of the genetic variation in the Sudan core set might be present in breeding programs but remains unexploited within some clusters of accessions. CONCLUSIONS: The NPGS Sudan core collection comprises genetically and phenotypically diverse germplasm with multiple anthracnose resistance sources. Population genomic analysis could be used to improve screening efforts and identify the most valuable germplasm for breeding programs. The new GBS data set generated in this study represents a novel genomic resource for plant breeders interested in mining the genetic diversity of the NPGS sorghum collection.