RESUMO
A total of 290 cases of tarsal gland adenomas and epitheliomas from canine patients were analyzed to determine the frequency and to better characterize their histopathological features. Tissue samples were examined in two veterinary pathology laboratories in Curitiba, Brazil, which receive samples from all over the country. Tarsal epitheliomas were significantly more frequent than tarsal adenomas (77.9% and 20.7%, respectively). In four cases (1.4%), the lesion contained both types of neoplasms. A total of 39 breeds were represented. The most common breeds were: English cocker spaniel (12.4%), poodle (10.3%) and Labrador retriever (9.3%). Mixed breed dogs represented 13.1% of the total. The upper eyelids were most commonly affected (65.2%), males and females were equally represented and there did not appear to be a predilection for either side of the face. Mitotic figures were most common in epitheliomas. The pigmented subtype was the most common form of epithelioma (59.7%). Whereas within the adenomas, the classic subtype (without inflammation or pigmentation) was the most common form (61.7%); and the inflamed subtype was also highly represented (20.0%).
Assuntos
Animais , Cães , Adenoma/epidemiologia , Adenoma/veterinária , Carcinoma/epidemiologia , Glândulas Tarsais/patologia , Tarso Animal/patologiaRESUMO
A total of 290 cases of tarsal gland adenomas and epitheliomas from canine patients were analyzed to determine the frequency and to better characterize their histopathological features. Tissue samples were examined in two veterinary pathology laboratories in Curitiba, Brazil, which receive samples from all over the country. Tarsal epitheliomas were significantly more frequent than tarsal adenomas (77.9% and 20.7%, respectively). In four cases (1.4%), the lesion contained both types of neoplasms. A total of 39 breeds were represented. The most common breeds were: English cocker spaniel (12.4%), poodle (10.3%) and Labrador retriever (9.3%). Mixed breed dogs represented 13.1% of the total. The upper eyelids were most commonly affected (65.2%), males and females were equally represented and there did not appear to be a predilection for either side of the face. Mitotic figures were most common in epitheliomas. The pigmented subtype was the most common form of epithelioma (59.7%). Whereas within the adenomas, the classic subtype (without inflammation or pigmentation) was the most common form (61.7%); and the inflamed subtype was also highly represented (20.0%).(AU)
Assuntos
Animais , Cães , Adenoma/epidemiologia , Adenoma/veterinária , Carcinoma/epidemiologia , Glândulas Tarsais/patologia , Tarso Animal/patologiaRESUMO
OBJECTIVE: To determine the effects of RC-3095 in clinical and histopathologic parameters and inflammatory mediators on complete Freund's adjuvant-induced arthritis (CFA). METHODS: The arthritis was induced by injection of CFA into the left hind footpad. The animals were divided into control, vehicle injected control, placebo group (saline subcutaneously 50ml/kg, once daily for 8 days after modeling), treatment group (0.3mg/kg of RC-3095 subcutaneously, once daily for 8 days after induction). Clinical evaluation was accomplished daily, through scoring of the paw edema. The animals were sacrificed 15 days after induction for collection of hind foot joints for histology. We used a histological scoring system which was previously described, and interferon (INF)-gamma, interleukin (IL)-1beta, tumor necrosis factor (TNF), interleukin (IL)-6 and interleukin (IL)-10 were measured by ELISA. RESULTS: There was a significant inhibition of joint histological findings in the RC-3095 treated group, including synovial inflammatory infiltration and hyperplasia, cartilage and bone erosion. IFN-gamma, IL-1beta, TNF, IL-6 and IL-10 serum levels were significantly lower in the treated group. Paw swelling and subcutaneous inflammation, evaluated clinically, were not different between CFA-induced groups. CONCLUSIONS: RC-3095 was able to improve experimental arthritis, attenuate joint damage and decrease serum levels of IFN-gamma, IL-1beta, TNF, IL-6 and IL-10. These data indicate that interference with GRP pathway is a potential new strategy for the treatment of RA that needs further investigational studies.