RESUMO
La guía incluye estrategias innovadoras, como un modelo de tamizaje y tratamiento de casos que orienta a los profesionales de la salud para el manejo adecuado del cáncer de cuello uterino a nivel nacional
Assuntos
Esfregaço Vaginal , Carcinoma , Displasia do Colo do Útero , Programas de Rastreamento , Tumor Misto Maligno , Crioterapia , Colposcopia , Infecções por Papillomavirus , Fatores de Poliadenilação e Clivagem de mRNA , NeoplasiasRESUMO
CONTEXT: Gastric stump cancer after gastric resection is a well-known disease. It may be a newly developed cancer after resection due to benign disease, or recurrent or residual disease after oncological surgery. The predominant histological type is usually adenocarcinoma. This study aimed to report on a rare occurrence of a mixed adenoneuroendocrine carcinoma (MANEC) on the gastric stump. CASE REPORT: The case of an 83-year-old female who presented a locally aggressive gastric stump MANEC, 35 years after Billroth II gastrectomy to treat a peptic ulcer, is reported. The patient underwent resection and adjuvant therapy. She has been followed up for one year without signs of recurrence. CONCLUSION: MANEC is a rare type of gastrointestinal neoplasm. The classification, histopathology, clinical features, treatment issues and prognosis are discussed along with a brief review of the literature.
CONTEXTO: O câncer de coto gástrico após gastrectomia é uma condição extensamente documentada. Pode se tratar de doença desenvolvida após a ressecção por doença benigna, ou ainda doença recorrente ou residual após cirurgia oncológica. Geralmente, o tipo histológico predominante é o adenocarcinoma. Este estudo tem como propósito relatar a rara ocorrência de um adenocarcinoma neuroendócrino misto (MANEC) no coto gástrico. RELATO DE CASO: É relatado o caso de uma mulher de 83 anos que apresentou um MANEC localmente agressivo 35 anos após uma gastrectomia à Billroth II devido a úlcera péptica. Foi submetida a ressecção e terapia adjuvante e foi seguida por 12 meses sem sinais de recorrência. CONCLUSÃO: Os MANECs constituem raro tipo de neoplasia gastrointestinal. Sua classificação, histopatologia, aspectos clínicos, tratamento e prognóstico são discutidos junto com uma breve revisão de literatura.
Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Neoplasias Gástricas/cirurgia , Adenocarcinoma/cirurgia , Tumor Misto Maligno/cirurgia , Carcinoma Neuroendócrino/cirurgia , Coto Gástrico/cirurgia , Neoplasias Gástricas/terapia , Gastroenterostomia , Adenocarcinoma/terapia , Tumor Misto Maligno/terapia , Carcinoma Neuroendócrino/terapia , Quimiorradioterapia Adjuvante/métodosRESUMO
CONTEXT: Gastric stump cancer after gastric resection is a well-known disease. It may be a newly developed cancer after resection due to benign disease, or recurrent or residual disease after oncological surgery. The predominant histological type is usually adenocarcinoma. This study aimed to report on a rare occurrence of a mixed adenoneuroendocrine carcinoma (MANEC) on the gastric stump. CASE REPORT: The case of an 83-year-old female who presented a locally aggressive gastric stump MANEC, 35 years after Billroth II gastrectomy to treat a peptic ulcer, is reported. The patient underwent resection and adjuvant therapy. She has been followed up for one year without signs of recurrence. CONCLUSION: MANEC is a rare type of gastrointestinal neoplasm. The classification, histopathology, clinical features, treatment issues and prognosis are discussed along with a brief review of the literature.
Assuntos
Adenocarcinoma/cirurgia , Carcinoma Neuroendócrino/cirurgia , Coto Gástrico/cirurgia , Tumor Misto Maligno/cirurgia , Neoplasias Gástricas/cirurgia , Adenocarcinoma/terapia , Idoso de 80 Anos ou mais , Carcinoma Neuroendócrino/terapia , Quimiorradioterapia Adjuvante/métodos , Feminino , Gastroenterostomia , Humanos , Tumor Misto Maligno/terapia , Neoplasias Gástricas/terapiaRESUMO
Patients with hepatocellular carcinoma (HCC), the fifth most common cancer worldwide, display a highly variable clinical course, suggesting that HCC encompasses several biologically distinct subtypes. This heterogeneity has the potential to impede both treatment decisions and prognostic predictions for patients with HCC. One distinct, albeit rare, subtype of HCC is combined hepatocellular-cholangiocarcinoma (cHCC-CC), which overall carries a poorer prognosis than HCC and cholangiocarcinoma (CC) alone. This review discusses predominantly the histopathologic and pathogenetic intricacies of this tumor and highlights the need for an accurate diagnosis of this specific HCC subtype.
Assuntos
Carcinoma Hepatocelular/patologia , Colangiocarcinoma/patologia , Neoplasias Hepáticas/patologia , Tumor Misto Maligno/patologia , Carcinoma Hepatocelular/epidemiologia , Carcinoma Hepatocelular/cirurgia , Colangiocarcinoma/epidemiologia , Colangiocarcinoma/cirurgia , Humanos , Neoplasias Hepáticas/epidemiologia , Neoplasias Hepáticas/cirurgia , Tumor Misto Maligno/epidemiologia , Tumor Misto Maligno/cirurgiaRESUMO
Se realizó un estudio descriptivo y transversal sobre la mortalidad por cáncer en la provincia de Santiago de Cuba durante 2010, dada por 1 819 fallecidos por esa causa, para una tasa de 173,9 por cada 100 000 habitantes; cifra aumentada respecto al año anterior, con predominio de la sobremortalidad masculina, de los ancianos de 75 y más años, así como también de los municipios de Mella y II Frente. Los tumores malignos más comunes en las mujeres se localizaron en pulmón, mama y colon, mientras que en los hombres se diagnosticaron preponderantemente en próstata, pulmón y colon, por lo cual se recomienda dirigir y planificar las acciones sanitarias según el riesgo de mortalidad estratificado en cada municipio de esta provincia.
A descriptive and cross-sectional study on mortality due to cancer in Santiago de Cuba province during 2010 was carried out, taking into account 1 819 deceased at a rate of 173,9 every 100 000 inhabitants. This rate increased compared to the previous year with a male mortality predominance of elderly aged 75 and over, as well as mortality in Mella and II Frente municipalities. Most common malignancies in women were detected in lungs, breast, and colon; while in men, they were preponderantly diagnosed in prostate, lungs, and colon. For this reason, it is recommendable addressing and planning health actions according to the stratified mortality risk in each municipality of this province.
Assuntos
Humanos , Tumor Misto Maligno , Mortalidade , Neoplasias/mortalidade , Estatísticas de Saúde , Estudos Transversais , Epidemiologia DescritivaRESUMO
Germ cell tumors (GCT) are a heterogeneous group of lesions whose origin is not well established. Several cases of primary intrasellar germinomas have been reported, however non-germinomatous GCT have rarely been described. We report the case of a young adult male patient with a mixed GCT that presented with a sellar tumor with suprasellar extension. The patient seeked medical attention because of seizures and magnetic resonance imaging evidenced a tumor of the sellar region. Hyperprolactinemia was also present and dopamine agonist therapy was started. As there was a rapid tumor growth and the patient had concomitant central diabetes insipidus and elevated testosterone levels, a GCT was suspected and confirmed by elevated serum concentration of ß-human chorionic gonadotrophin. Patient underwent surgical resection of the tumor and histopathological examination confirmed the diagnosis of a mixed GCT. Chemotherapy was initiated, followed by conventional radiotherapy. In conclusion, although pituitary adenomas respond for the vast majority of sellar tumors, concomitant symptoms such as central diabetes insipidus and rapid tumor growth should raise the suspicion of a diverse diagnosis. The present report intend not only to show a rare case of sellar and suprasellar mixed GCT but also to remind clinicians that if laboratory findings do not fit into patient's diagnosis (such as high testosterone levels in our patient), then the diagnosis should be reviewed.
Assuntos
Adenoma/diagnóstico , Tumor Misto Maligno/diagnóstico , Neoplasias Embrionárias de Células Germinativas/diagnóstico , Neoplasias Hipofisárias/diagnóstico , Sela Túrcica/patologia , Adenoma/patologia , Adulto , Diagnóstico Diferencial , Humanos , Masculino , Tumor Misto Maligno/patologia , Neoplasias Embrionárias de Células Germinativas/patologia , Neoplasias Hipofisárias/patologiaRESUMO
Constituyen el 15-20% aproximadamente de la patologìa tumoral ginecològica.70% se desarrolla a partir del epitelio germinal.20% son de naturaleza maligna.
Assuntos
Tumor Misto Maligno/congênito , Tumor Misto Maligno/sangue , Tumor Misto Maligno , Tumor Misto Maligno/urina , ParaguaiRESUMO
El tumor de colisión es una variante poco frecuente de tumores del cérvix uterino, originados de las células de reserva de la unión escamocelular y que debe ser diferenciado de los carcinomas adenoescamosos. El objetivo del presente artículo es determinar las características morfológicas de 17 casos de tumor de colisión de cérvix uterino. La edad promedio de presentación fue 48,7 años (rango: 34-87 años). Los 4 casos con metástasis ganglionares correspondieron al componente de adenocarcinoma.
Collision tumor is an uncommon variant of cervical tumors originating from the reserve cells of squamous cell union and must be differentiated from adenosquamous carcinomas. The aim of this paper is to determine the morphological characteristics of 17 cases of collision tumor of uterine cervix, in which it was found that the average age at diagnosis was 48.7 years (range: 34-87 years). In 5 cases lymph node metastases were of the adenocarcinoma component.
Assuntos
Humanos , Adulto , Feminino , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Adenocarcinoma/patologia , Carcinoma de Células Escamosas/patologia , Neoplasias Primárias Múltiplas/patologia , Neoplasias do Colo do Útero/patologia , Carcinoma Adenoescamoso/patologia , Diagnóstico Diferencial , Metástase Linfática , Tumor Misto MalignoRESUMO
The following case is a 69-year-old woman with a presumptive diagnosis of adenocarcinoma in transverse colon, which was diagnosed by pathology as a mixed carcinoid-adenocarcinoma tumor after surgery. We have found very few cases published of this type of tumor in the colon (around 20) but not cases in the transverse colon. We discuss in the following report the diagnosis, the therapeutic conduct and its results. We point out with particular consideration that, due to the lack of information related to the functional behaviour and clinical characteristics of these mixed tumors, more studies, analysis, follow-up and descriptions are necessary to perform future diagnosis and therapeutic procedures.
Assuntos
Adenocarcinoma/diagnóstico , Tumor Carcinoide/diagnóstico , Colo Transverso/patologia , Neoplasias do Colo/diagnóstico , Tumor Misto Maligno/diagnóstico , Adenocarcinoma/tratamento farmacológico , Idoso , Antimetabólitos Antineoplásicos/uso terapêutico , Tumor Carcinoide/tratamento farmacológico , Neoplasias do Colo/tratamento farmacológico , Feminino , Fluoruracila/uso terapêutico , Humanos , Tumor Misto Maligno/tratamento farmacológico , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
The immunohistochemical expression of p63, DeltaNp63, and p53 was studied in mixed tumors of canine mammary glands (13 benign mixed tumors and 19 carcinomas arising from benign mixed tumors) to determine the role of p63 and its isoform DeltaNp63 in the development of mixed tumors, as well as to assess its relation with p53. P63 was expressed in myoepithelial cells of all benign mixed tumors and in 18 of 19 carcinomas in mixed tumors. The p63-negative carcinoma in mixed tumors was invasive, and a loss of p63 was detected in the other malignant tumors showing a discontinuous p63-stained myoepithelial layer. DeltaNp63 was expressed in all benign mixed tumors but only in p63-positive carcinomas in mixed tumors. Despite its positive correlation with p63 expression in carcinomas in mixed tumors (r = 0.8323, P < .00001), DeltaNp63 expression showed a decrease in benign tumors. Positivity for p53 was detected in 2 of 13 and 1 of 19 benign mixed tumors and carcinomas in mixed tumors, respectively. There was no correlation between p63 or DeltaNp63 and p53 expression. Our data support the notion that the decrease of p63 expression, in particular of its isoform DeltaNp63, seems to be an important factor in the development of carcinomas in mixed tumors.