Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity

Lima-Junior, Jose Carlos de; Virginio, Vitor W. M; Moura, Filipe A; Bertolami, Adriana; Bertolami, Marcelo; Coelho-Filho, Otavio R; Zanotti, Ilaria; Nadruz, Wilson; Faria, Eliana Cotta de; Carvalho, Luiz Sergio F. de; Sposito, Andrei C

Lima-Junior, Jose Carlos de; Virginio, Vitor W. M; Moura, Filipe A; Bertolami, Adriana; Bertolami, Marcelo; Coelho-Filho, Otavio R; Zanotti, Ilaria; Nadruz, Wilson; Faria, Eliana Cotta de; Carvalho, Luiz Sergio F. de; Sposito, Andrei C.

Afiliação

Lima-Junior, Jose Carlos de; State University of Campinas. São Paulo. BR
Virginio, Vitor W. M; State University of Campinas. São Paulo. BR
Moura, Filipe A; State University of Campinas. Brigham and Women's Hospital. São Paulo. BR
Bertolami, Adriana; Dante Pazzanese Cardiological Institute. São Paulo. BR
Bertolami, Marcelo; Dante Pazzanese Cardiological Institute. São Paulo. BR
Coelho-Filho, Otavio R; State University of Campinas. São Paulo. BR
Zanotti, Ilaria; University of Parma. Parma. IT
Nadruz, Wilson; State University of Campinas. São Paulo. BR
Faria, Eliana Cotta de; State University of Campinas. São Paulo. BR
Carvalho, Luiz Sergio F. de; State University of Campinas. São Paulo. BR
Sposito, Andrei C; State University of Campinas. São Paulo. BR

Nutr. metab. cardiovasc. dis ; 30(2): 254-264, Feb., 2020. tab., graf.

Article em En | SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1052921

Biblioteca responsável: BR79.1

Localização: BR79.1

ABSTRACT

ABSTRACT

BACKGROUND AND

AIM:

Obesity-related decline in high-density lipoprotein (HDL) functions such as cholesterol efflux capacity (CEC) has supported the notion that this lipoprotein dysfunction may contribute for atherogenesis among obese patients. We investigated if potentially other HDL protective actions may be affected with weight gain and these changes may occur even before the obesity range in a cross-sectional analysis. METHODS AND

RESULTS:

Lipid profile, body mass index (BMI), biochemical measurements, and carotid intima-media thickness (cIMT) were obtained in this cross-sectional study with 899 asymptomatic individuals. Lipoproteins were separated by ultracentrifugation and HDL physical-chemical characterization, CEC, antioxidant activity, anti-inflammatory activity, HDL-mediated platelet aggregation inhibition were measured in a randomly-selected subgroup (n = 101). Individuals with increased HDL-C had an attenuated increase in cIMT with elevation of BMI (interaction effect ß = -0.054; CI 95% -0.0815, -0.0301). CEC, HDL-C, HDL size and HDL-antioxidant activity were negatively associated with cIMT. BMI was inversely correlated with HDL-mediated inhibition of platelet aggregation (Spearman's rho -0.157, p < 0.03) and CEC (Spearman's rho -0.32, p < 0.001), but surprisingly it was directly correlated with the antioxidant activity (Spearman's rho 0.194, p = 0.052). Thus, even in non-obese, non-diabetic individuals, increased BMI is associated with a wide change in protective functions of HDL, reducing CEC and increasing antioxidant activity. In these subjects, decreased HDL concentration, size or function are related to increased atherosclerotic burden.

CONCLUSION:

Our findings demonstrate that in non-obese, non-diabetic individuals, the increasing values of BMI are associated with impaired protective functions of HDL and concomitant increase in atherosclerotic burden. (AU)

Assuntos

Aterosclerose; HDL-Colesterol; Obesidade

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Texto completo: 1 Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IDPCPROD Assunto principal: Aterosclerose / HDL-Colesterol / Obesidade Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Nutr. metab. cardiovasc. dis Ano de publicação: 2020 Tipo de documento: Article

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