A lipocalin sequence signature modulates cell survival

Tavassi, Ana Marisa Chudzinski; Carvalho, , Linda C  Carrijo; Waismam, , Kaline; Farsky, Sandra H P; Ramos, Oscar; Reis, , Cleyson V

Tavassi, Ana Marisa Chudzinski; Carvalho, , Linda C Carrijo; Waismam, , Kaline; Farsky, Sandra H P; Ramos, Oscar; Reis, , Cleyson V.

Afiliação

Tavassi, Ana Marisa Chudzinski; Instituto Butantan. São Paulo. BR
Carvalho, , Linda C Carrijo; Instituto Butantan. São Paulo. BR
Waismam, , Kaline; s.af
Farsky, Sandra H P; s.af
Ramos, Oscar; Instituto Butantan. São Paulo. BR
Reis, , Cleyson V; Instituto Butantan. São Paulo. BR

FEBS Letters ; 584(13): 2896-2900, 2010.

Article em En | SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO | ID: biblio-1062806

Biblioteca responsável: BR78.1

Localização: BR78.1

ABSTRACT

ABSTRACT

Lipocalins are â-barrel proteins, which share three conserved motifs in their amino acid sequence. In this study, we identified by a peptide mapping approach, a seven-amino acid sequence related to one of these motifs (motif 2) that modulates cell survival. A synthetic peptide based on an insect lipocalin displayed cytoprotective activity in serum-deprived endothelial cells and leucocytes. This activity was dependent on nitric oxide synthase. This sequence was found within several lipocalins, including apolipoprotein D, retinol binding protein, lipocalin-type prostaglandin D synthase, and many unknown proteins, suggesting that it is a sequence signature and a lipocalin conserved property.

Assuntos

Masculino; Feminino; Humanos; Apoptose; Lipocalinas; Sobrevivência Celular

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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IBACERVO / SESSP-IBPROD Assunto principal: Sobrevivência Celular / Apoptose / Lipocalinas Limite: Female / Humans / Male Idioma: En Revista: FEBS Letters Ano de publicação: 2010 Tipo de documento: Article

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