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The usefulness of T-wave peak to T-wave endInterval in identifying malignant arrhythmias in patients with chagas disease
Armaganijan, Luciana; Moreira, Dalmo A; Araújo, Roberta R. Nolasco de; Puzzi, Marcelo A; Munhoz, Fernando P; Carvalho, Murilo J; Gallo, Lilian N; França, João Ítalo D; Lopes, Renato D.
Afiliação
  • Armaganijan, Luciana; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Moreira, Dalmo A; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Araújo, Roberta R. Nolasco de; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Puzzi, Marcelo A; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Munhoz, Fernando P; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Carvalho, Murilo J; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Gallo, Lilian N; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • França, João Ítalo D; Instituto Dante Pazzanese de Cardiologia. São Paulo. BR
  • Lopes, Renato D; Duke Clinical Research Institute. Durham. US
Hell. j. cardiol ; 54: 429-434, 2013. ilus
Article em En | SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1063275
Biblioteca responsável: BR79.1
Localização: BR79.1
ABSTRACT

Introduction:

Abnormal ventricular repolarization has been proposed as a marker of arrhythmogenesis, andcardiovascular morbidity and mortality. However, little is known about the influence of the interval betweenthe peak and the end of the T wave (Tp-Te) on the inducibility of sustained ventricular arrhythmias (VA) inpatients with Chagas disease (CD).

Methods:

Using a case-control design, chagasics undergoing electrophysiological study (EPS) in the lastthree years were matched by age and sex. Cases represented those with positive EPS and controls thosewith no inducible VA. Tp-Te>100 ms was considered abnormal. Logistic regression analysis was performedto assess the association between Tp-Te and a positive EPS, after adjusting for confounders.

Results:

A total of 105 patients (mean age 56 years, 52.4% male) were included 41 (39%) had a positiveEPS; 85.4% with inducible VA (n=35) had non-sustained ventricular tachycardia on the Holter monitoring,compared to 62.5% with negative EPS (n=40, p<0.001). While ventricular aneurysm (adjustedOR=5.3, 95% CI 1.11-24.96, p=0.03) and coronary artery disease (adjusted OR=8.8, 95% CI 1.45-53.15, p=0.01) were associated with an increased risk of malignant arrhythmias, a greater ejection fraction(adjusted OR=0.96, 95% CI 0.93-0.99, p<0.01) was associated with a lower risk of VA. Prolonged Tp-Tetrended to be associated with an increased risk of induced VA (p=0.07).

Conclusions:

Ventricular aneurysm, coronary artery disease, and ejection fraction are associated with inducibleVA. Prolonged TP-Te may have a modest role in the identification of patients with CD who are at highrisk for VA. Further studies are warranted to validate our results and to correlate them with clinical outcomes.
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IDPCPROD Assunto principal: Arritmias Cardíacas / Doença de Chagas / Taquicardia Ventricular Idioma: En Revista: Hell. j. cardiol Ano de publicação: 2013 Tipo de documento: Article
Buscar no Google
Adicionar na Minha BVS
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Coleções: 06-national / BR Base de dados: SES-SP / SESSP-IDPCPROD Assunto principal: Arritmias Cardíacas / Doença de Chagas / Taquicardia Ventricular Idioma: En Revista: Hell. j. cardiol Ano de publicação: 2013 Tipo de documento: Article