Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibrom
An. bras. dermatol
; 95(5): 627-630, Sept.-Oct. 2020. graf
Article
em En
| LILACS, ColecionaSUS
| ID: biblio-1130934
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Dermatofibroma is a dermal fibrohistiocytic neoplasm. The Langerhans cells are the immunocompetent cells of the epidermis, and they represent the first defense barrier of the immune system towards the environment. The objective was to immunohistologically compare the densities of S100-positive Langerhans cells in the healthy peritumoral epidermis against those in the epidermis overlying dermatofibroma (20 cases), using antibodies against the S100 molecule (the immunophenotypic hallmark of Langerhans cells). The control group (normal, healthy skin) included ten healthy age and sex-matched individuals who underwent skin biopsies for benign skin lesions. A significantly high density of Langerhans cells was observed both in the epidermis of the healthy skin (6.00 ± 0.29) and the peritumoral epidermis (6.44 ± 0.41) vs. those in the epidermis overlying the tumor (1.44 ± 0.33, p < 0.05). The quantitative deficit of Langerhans cells in the epidermis overlying dermatofibroma may be a possible factor in its development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
/
ColecionaSUS
Assunto principal:
Neoplasias Cutâneas
/
Histiocitoma Fibroso Benigno
Limite:
Humans
Idioma:
En
Revista:
An. bras. dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Egito
País de publicação:
Brasil