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Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil
Martins, Willames M.B.S.; Toleman, Mark A.; Gales, Ana C..
Afiliação
  • Martins, Willames M.B.S.; Universidade Federal de São Paulo. Escola Paulista de Medicina, Departamento de Medicina Interna. São Paulo. BR
  • Toleman, Mark A.; Cardiff University. Department of Infection and Immunity. Cardiff. GB
  • Gales, Ana C.; Universidade Federal de São Paulo. Escola Paulista de Medicina, Departamento de Medicina Interna. São Paulo. BR
Braz. j. infect. dis ; 24(3): 239-246, May-June 2020. graf
Article em En | LILACS-Express | LILACS, ColecionaSUS | ID: biblio-1132442
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT Due to the emergence of multi-drug resistant bacteria, and the evident limitation in therapeutic options, alternatives to combat bacterial infections have been sought. One of these is phage therapy, which is the use of bacterial viruses to kill pathogenic bacteria responsible for the infection. These viruses called bacteriophages are very abundant organisms in the world and are harmless to humans. There are several advantages in using phage therapy, especially against multi-drug resistant pathogens, which tend to be dominated by individual strains. The advantages include fewer collateral effects such as lower disturbance of gut microbiota and less antimicrobials consumption, which itself leads to reducing antibiotic resistance rates. Unfortunately, few clinical studies have been initiated in Brazil and this area is little explored in our country. This manuscript describes clinical evidence of successful phage utilization on pathogens considered a threat in Brazil, highlighting the benefits of a possible phage utilization as an important tool to combat antimicrobial resistance in our country.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / ColecionaSUS País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article / Project document País de afiliação: Brasil / Reino Unido País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / ColecionaSUS País/Região como assunto: America do sul / Brasil Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article / Project document País de afiliação: Brasil / Reino Unido País de publicação: Brasil