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Pentraxin-2 is associated with renal fibrosis in patients undergoing renal biopsy
Basturk, Taner; Ojalvo, David; Mazi, Emrah Erkan; Hasbal, Nuri Baris; Ozagari, Ayse Aysim; Ahbap, Elbis; Sakaci, Tamer; Koc, Yener; Sevinc, Mustafa; Unsal, Abdulkadir.
Afiliação
  • Basturk, Taner; Sisli Hamidiye Etfal Teaching and Research Hospital. University of Health Sciences. Istanbul. TR
  • Ojalvo, David; Department of Nephrology. Sisli Hamidiye Etfal Teaching and Research Hospital. Istanbul. TR
  • Mazi, Emrah Erkan; General Medicine. Vardcentralen Wisby Soder. Gotland. SE
  • Hasbal, Nuri Baris; Department of Nephrology. Hakkari State Hospital. Hakkari. TR
  • Ozagari, Ayse Aysim; Department of Pathology. Sisli Hamidiye Etfal Teaching and Research Hospital. Istanbul. TR
  • Ahbap, Elbis; General Medicine. Vardcentralen Wisby Soder. Gotland. SE
  • Sakaci, Tamer; General Medicine. Vardcentralen Wisby Soder. Gotland. SE
  • Koc, Yener; Department of Internal Medicine, Division of Nephrology. Faculty of Medicine. Cumhuriyet University. Sivas. TR
  • Sevinc, Mustafa; General Medicine. Vardcentralen Wisby Soder. Gotland. SE
  • Unsal, Abdulkadir; Sisli Hamidiye Etfal Teaching and Research Hospital. University of Health Sciences. Istanbul. TR
Clinics ; 75: e1809, 2020. tab, graf
Article em En | LILACS | ID: biblio-1133436
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

Progressive renal disease is characterized by histological changes in the kidney and fibrosis is a common outcome. Renal biopsy is the only diagnostic tool to evaluate these histopathological changes. Pentraxin-2 (PTX-2) is an anti-inflammatory constitutive plasma protein associated with the innate immune system. Recently, as a biomarker, the circulating level of PTX-2 is shown to be decreased in chronic fibrotic diseases. In this study, we aimed to investigate the relationship between renal fibrosis severity and serum PTX-2 levels in patients undergoing renal biopsy.

METHODS:

This cross-sectional study included 45 patients and 16 healthy individuals (HIs). The severity of renal fibrosis was evaluated according to the Banff and Sethi scoring systems by the same pathologist. PTX-2 was measured by an enzyme-linked immunosorbent assay and compared with the demographical, clinical, biochemical, and histopathological data of the patients and HIs.

RESULTS:

PTX-2 levels were lower in the biopsy group than in the HI group (p=0.12). Patients with moderate renal fibrosis had significantly lower serum PTX-2 levels than those in patients with minimal and mild fibrosis (p=0.017 and p=0.010, respectively). PTX-2 concentrations were correlated with serum albumin (r=0.30, p=0.016), and were negatively correlated with serum creatinine levels (rho=-0.42, p=0.01) and body mass index (r=-0.32, p=0.011).

CONCLUSIONS:

The results indicated that PTX-2 levels are significantly lower in patients with renal fibrosis than HIs, and declining further in patients with severe fibrosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Proteína C-Reativa Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suécia / Turquia País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Proteína C-Reativa Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suécia / Turquia País de publicação: Brasil