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Rapid method for diagnosis of leprosy by measurements of antibodies to the M. leprae 35-kDa protein: comparison with PGL-1 antibodies detected by ELISA and Dipstick methods
Roche, Paul W; Failbus, Sarah S; Britton, Warwick J; Cole, Robert.
Afiliação
  • Roche, Paul W; Anandaban Leprosy Hospital. Mycobacterial Research Laboratory. Kathmandu. NP
  • Failbus, Sarah S; Anandaban Leprosy Hospital. Mycobacterial Research Laboratory. Kathmandu. NP
  • Britton, Warwick J; Centenary Institute of Cancer Medicine and Cell Biology. Sydney. AU
  • Cole, Robert; Amrad ICT Diagnostics. New South Wales. AU
Int. j. lepr. other mycobact. dis ; 67(3): 279-286, Sept., 1999. ilus, graf
Article em En | SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP | ID: biblio-1226886
Biblioteca responsável: BR191.1
Localização: [{"text": "BR191.1"}]
ABSTRACT
A new rapid immuno-chromatographic test card for the detection of antibodies to the Mycobacterium leprae 35-kD protein is described. The new assay is compared in the same group of subjects with a direct enzyme ELISA method for 35-kD antibodies and with assays for anti-phenolic glycolipid-I (PGL-I) antibodies using a standard ELISA as well as the recently described [quot ]dipstick[quot ] method. Good concordance was found between the rapid methods and the corresponding ELISA methods. The detection of untreated paucibacillary leprosy by the 35-kD test card was 59% compared with 27% for the PGL-I dipstick; however, the specificity for the 35-kD test card was 90% compared with 100% for the PGL-I dipstick in an endemic population. The potential application of these new, rapid serologic methods for the diagnosis of leprosy under field conditions is discussed.
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Texto completo: 1 Coleções: 06-national / BR Base de dados: HANSEN / HANSENIASE / SES-SP / SESSP-ILSLACERVO Assunto principal: Ensaio de Imunoadsorção Enzimática / Mycobacterium leprae Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Int. j. lepr. other mycobact. dis Ano de publicação: 1999 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 06-national / BR Base de dados: HANSEN / HANSENIASE / SES-SP / SESSP-ILSLACERVO Assunto principal: Ensaio de Imunoadsorção Enzimática / Mycobacterium leprae Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Int. j. lepr. other mycobact. dis Ano de publicação: 1999 Tipo de documento: Article