Vaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae

Roche, Paul W; Neupane, Kapil Dev; Failbus, Sarah S; Kamath, Arun; Britton, Warwick J

Roche, Paul W; Neupane, Kapil Dev; Failbus, Sarah S; Kamath, Arun; Britton, Warwick J.

Afiliação

Roche, Paul W; Anandaban Leprosy Hospital. Mycobacterial Research Laboratory. NP
Neupane, Kapil Dev; Anandaban Leprosy Hospital. Mycobacterial Research Laboratory. NP
Failbus, Sarah S; Anandaban Leprosy Hospital. Mycobacterial Research Laboratory. NP
Kamath, Arun; Centenary Institute of Cancer Medicne & Cell Biology. AU
Britton, Warwick J; Centenary Institute of Cancer Medicne & Cell Biology. AU

Int. j. lepr. other mycobact. dis ; 69(2): 93-98, Jun., 2001. tab, graf

Article em En | SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP | ID: biblio-1227007

Biblioteca responsável: BR191.1

Localização: [{"text": "BR191.1"}]

ABSTRACT

ABSTRACT

A DNA vaccine composed of the gene for the common mycobacterial secreted protein antigen 85B was demonstrated to protect the mouse foot pad against infection with Mycobacterium leprae. The protective effect was demonstrated by a 61%-88% reduction in the bacterial number, a protective effect less than that of BCG. The same DNA vaccine has been shown to protect mice against M. tuberculosis infection, and the importance of testing other candidate tuberculosis vaccines for their potential to protect against leprosy is discussed.

Assuntos

Humanos; DNA; Mycobacterium leprae/imunologia; Mycobacterium tuberculosis/imunologia

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Texto completo: 1 Coleções: 06-national / BR Base de dados: HANSEN / HANSENIASE / SES-SP / SESSP-ILSLACERVO Assunto principal: DNA / Mycobacterium leprae / Mycobacterium tuberculosis Limite: Humans Idioma: En Revista: Int. j. lepr. other mycobact. dis Ano de publicação: 2001 Tipo de documento: Article

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