Infections mycobactériennes humaines: im´pact des facteurs génetiques de lhôte / Human mycobacterial infections: impact of host genetic factors
s.l; s.n; 2002. 6 p. ilus.
Non-conventional
em Fr
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1240954
Biblioteca responsável:
BR191.1
Localização: [{"text": "BR191.1", "_a": "09052/s"}]
ABSTRACT
Humans are exposed worldwide to a variety of environmental mycobacteria (EM) and most children are inoculated with live Bacille Calmette-Guérin (BCG) vaccine. Although rarely pathogenic, poorly virulent mycobacteria, including BCG and most EM, may cause a variety of clinical diseases. M. tuberculosis and M. leprae are more virulent, causing tuberculosis, and leprosy, respectively. Remarkably, only a minority of individuals develop clinical disease, even if infected with virulent mycobacteria. There is now accumulating evidence that the large interindividual variability of clinical outcome results in part from variability in the human genes that control host defense. We review here in current knowledge about genetic predisposition to common (leprosy and tuberculosis) and rare (BCG and EM infections) mycobacterial infections.
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Coleções:
06-national
/
BR
Base de dados:
HANSEN
/
HANSENIASE
/
SES-SP
/
SESSP-ILSLACERVO
Assunto principal:
Tuberculose Pulmonar
/
Variação Genética
/
Predisposição Genética para Doença
/
Hanseníase
/
Mycobacterium
/
Infecções por Mycobacterium
Limite:
Humans
Idioma:
Fr
Ano de publicação:
2002
Tipo de documento:
Non-conventional
País de publicação:
Bélgica