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Bovine TMEM95 gene: Polymorphisms detecting in five Chinese indigenous cattle breeds and their association with growth traits
Guo, Xian; Zhang, Sihuan; Yang, Han; Pei, Jie; Wu, Xiaoyun; Bao, Pengjia; Liang, Chunnian; Xiong, Lin; Chu, Min; Lan, Xianyong; Yan, Ping.
Afiliação
  • Guo, Xian; Chinese Academy of Agricultural Sciences. Lanzhou Institute of Husbandry and Pharmaceutical Sciences. Lanzhou. CN
  • Zhang, Sihuan; Northwest A&F University. College of Animal Science and Technology. CN
  • Yang, Han; Northwest A&F University. College of Animal Science and Technology. CN
  • Pei, Jie; Chinese Academy of Agricultural Sciences. Lanzhou Institute of Husbandry and Pharmaceutical Sciences. Lanzhou. CN
  • Wu, Xiaoyun; Chinese Academy of Agricultural Sciences. Lanzhou Institute of Husbandry and Pharmaceutical Sciences. Lanzhou. CN
  • Bao, Pengjia; Chinese Academy of Agricultural Sciences. Lanzhou Institute of Husbandry and Pharmaceutical Sciences. Lanzhou. CN
  • Liang, Chunnian; Chinese Academy of Agricultural Sciences. Lanzhou Institute of Husbandry and Pharmaceutical Sciences. Lanzhou. CN
  • Xiong, Lin; Chinese Academy of Agricultural Sciences. Lanzhou Institute of Husbandry and Pharmaceutical Sciences. Lanzhou. CN
  • Chu, Min; Chinese Academy of Agricultural Sciences. Lanzhou Institute of Husbandry and Pharmaceutical Sciences. Lanzhou. CN
  • Lan, Xianyong; Northwest A&F University. College of Animal Science and Technology. CN
  • Yan, Ping; Chinese Academy of Agricultural Sciences. Lanzhou Institute of Husbandry and Pharmaceutical Sciences. Lanzhou. CN
Electron. j. biotechnol ; 51: 58-66, May. 2021. tab, ilus, graf
Article em En | LILACS | ID: biblio-1343388
Biblioteca responsável: CL1.1
ABSTRACT

BACKGROUND:

Transmembrane protein 95 (TMEM95) plays a role in male fertility. Previous studies showed that genes with a significant impact on reproductive traits can also affect the growth traits of livestock. Thus, we speculated that the genetic variation of TMEM95 gene may have effects on growth traits of cattle.

RESULTS:

Two SNPs were genotyped. The rs136174626 and rs41904693 were in the intron 4 and 30 -untranslated region, respectively. The linkage disequilibrium analysis illustrated that these two loci were not linked. The rs136174626 was associated with six growth traits of Nanyang cattle, four traits of Luxi cattle, and three traits of Ji'an cattle. For rs41904693 locus, the GG individuals had greater body height and abdominal girth in Ji' an cattle than TT and TG individuals. In Jinnan cattle, GG and TT individuals had greater body height, height at hip cross, body length, and heart girth than TG individuals. The potential splice site prediction results suggest that the rs136174626 may influence the splicing efficiency of TMEM95, and the miRNA binding site prediction results showed that the rs41904693 may influence the expression of TMEM95 by affecting the binding efficiency of Bta-miR-1584 and TMEM95 30 -UTR.

CONCLUSIONS:

The findings of the study suggested that the two SNPs in TMEM95 could be a reliable basis for molecular breeding in cattle.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Bovinos / Polimorfismo de Nucleotídeo Único / Proteínas de Membrana Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Electron. j. biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Chile
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Bovinos / Polimorfismo de Nucleotídeo Único / Proteínas de Membrana Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Electron. j. biotechnol Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Chile