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High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome
Braga, Aécio A; Bortolin, Raul H; Graciano-Saldarriaga, Magda E; Hirata, Thiago Dc; Cerda, Alvaro; Freitas, Renata Cc de; Lin-Wang, Hui T; Borges, Jessica B; França, João Id; Masi, Laureane N; Curi, Rui; Pithon-Curi, Tania C; Sampaio, Marcelo F; Castro, Lara R; Bastos, Gisele M; Hirata, Rosario Dc; Hirata, Mario H.
Afiliação
  • Braga, Aécio A; University of São Paulo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences. São Paulo. BR
  • Bortolin, Raul H; University of São Paulo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences. São Paulo. BR
  • Graciano-Saldarriaga, Magda E; University of São Paulo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences. São Paulo. BR
  • Hirata, Thiago Dc; University of São Paulo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences. São Paulo. BR
  • Cerda, Alvaro; Universidad de La Frontera. Department of Basic Sciences, Center of Excellence in Translational Medicine, CEMT-BIOREN. Temuco. CL
  • Freitas, Renata Cc de; University of São Paulo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences. São Paulo. BR
  • Lin-Wang, Hui T; Molecular Research Laboratory in Cardiology, Institute Dante Pazzanese of Cardiology. São Paulo. BR
  • Borges, Jessica B; Molecular Research Laboratory in Cardiology, Institute Dante Pazzanese of Cardiology. São Paulo. BR
  • França, João Id; Laboratory of Epidemiology and Statistics, Institute Dante Pazzanese of Cardiology. São Paulo. BR
  • Masi, Laureane N; Cruzeiro do Sul University. Interdisciplinary Post-graduate Program in Health Sciences. São Paulo. BR
  • Curi, Rui; Cruzeirodo Sul University. Interdisciplinary Post-graduate Program in Health Sciences. São Paulo. BR
  • Pithon-Curi, Tania C; Cruzeiro do Sul University. Interdisciplinary Post-graduate Program in Health Sciences. São Paulo. BR
  • Sampaio, Marcelo F; Medical Clinic Division, Institute Dante Pazzanese of Cardiology. Department of Cardiology, Real e Benemerita Associação Portuguesa de Beneficiência. São Paulo. BR
  • Castro, Lara R; Medical Clinic Division, Institute Dante Pazzanese of Cardiology. Department of Cardiology, Real e Benemerita Associação Portuguesa de Beneficiência. São Paulo. BR
  • Bastos, Gisele M; Molecular Research Laboratory in Cardiology, Institute Dante Pazzanese of Cardiology. Department of Teaching and Research, Real e Benemerita Associação Portuguesa de Beneficiencia. São Paulo. BR
  • Hirata, Rosario Dc; University of São Paulo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences. São Paulo. BR
  • Hirata, Mario H; University of São Paulo. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences. São Paulo. BR
Epigenomics (Online) ; 13(6): 423-436, Mar. 2021. ilus
Article em En | CONASS, SES-SP, SESSP-IDPCPROD, SES-SP | ID: biblio-1354234
Biblioteca responsável: BR79.1
ABSTRACT
ABSTRACT To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS).

METHODS:

Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulated miRNAs were validated in a larger cohort (MetS, n = 89; non-MetS, n = 144).

RESULTS:

In the screening study, seven miRNAs were dysregulated in patients with MetS, and miR-421 remained increased in the validation study. miR-421 was associated with a high risk of MetS and insulin resistance and hypertension and correlated with glycated hemoglobin, triacylglycerols, high-sensitivity CRP, IL-6, resistin and adiponectin (p < 0.05).

CONCLUSION:

Circulating miR-421 is a potential biomarker for insulin resistance, metabolic dysregulation and inflammatory status in patients with MetS.
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Coleções: 06-national / BR Base de dados: CONASS / SES-SP / SESSP-IDPCPROD Assunto principal: Síndrome Metabólica / Adiponectina / Adiposidade Tipo de estudo: Risk_factors_studies Idioma: En Revista: Epigenomics (Online) Ano de publicação: 2021 Tipo de documento: Article
Buscar no Google
Adicionar na Minha BVS
Imprimir
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Coleções: 06-national / BR Base de dados: CONASS / SES-SP / SESSP-IDPCPROD Assunto principal: Síndrome Metabólica / Adiponectina / Adiposidade Tipo de estudo: Risk_factors_studies Idioma: En Revista: Epigenomics (Online) Ano de publicação: 2021 Tipo de documento: Article