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Spectral characterization and biological evaluation of biomolecules from the peels of three orange fruits: a comparative study / Caracterização espectral e avaliação biológica de biomoléculas das cascas de três frutos de laranja: um estudo comparativo
Moni, S. S; Mohan, S; Makeen, H. A; Alhazmi, H. A; Basode, V. K; Rehman, Z; Alam, M. S; Alam, M. F; Anwer, T; Elmobark, M. E; Abdulhaq, A; Alamoudi, M. U. A; Hadi, I. M. H; Amri, S. A. A; Alrithi, A. M. A; Jathmi, Z. A. J; Kaabi, M. A. A.
Afiliação
  • Moni, S. S; Jazan University. College of Pharmacy. Department of Pharmaceutics. Jazan. SA
  • Mohan, S; Jazan University. Substance Abuse and Toxicology Research Centre. Jazan. SA
  • Makeen, H. A; Jazan University. College of Pharmacy. Pharmacy Practice Research Unit. Jazan. SA
  • Alhazmi, H. A; Jazan University. Substance Abuse and Toxicology Research Centre. Jazan. SA
  • Basode, V. K; Jazan University. College of Applied Medical Sciences. Unit of Medical Microbiology. Jazan. SA
  • Rehman, Z; Jazan University. College of Pharmacy. Department of Pharmaceutical Chemistry and Pharmacognosy. Jazan. SA
  • Alam, M. S; Jazan University. College of Pharmacy. Department of Pharmaceutical Chemistry and Pharmacognosy. Jazan. SA
  • Alam, M. F; Jazan University. College of Pharmacy. Department of Pharmacology and Toxicology. Jazan. SA
  • Anwer, T; Jazan University. College of Pharmacy. Department of Pharmacology and Toxicology. Jazan. SA
  • Elmobark, M. E; Jazan University. College of Pharmacy. Department of Pharmaceutics. Jazan. SA
  • Abdulhaq, A; Jazan University. College of Applied Medical Sciences. Unit of Medical Microbiology. Jazan. SA
  • Alamoudi, M. U. A; Jazan University. College of Pharmacy. Department of Pharmacology and Toxicology. Jazan. SA
  • Hadi, I. M. H; Jazan University. College of Pharmacy. Jazan. SA
  • Amri, S. A. A; Jazan University. College of Pharmacy. Jazan. SA
  • Alrithi, A. M. A; Jazan University. College of Pharmacy. Jazan. SA
  • Jathmi, Z. A. J; Jazan University. College of Pharmacy. Jazan. SA
  • Kaabi, M. A. A; Jazan University. College of Pharmacy. Jazan. SA
Braz. j. biol ; 82: e267856, 2022. tab, graf, ilus
Article em En | VETINDEX | ID: biblio-1420666
Biblioteca responsável: BR68.1
ABSTRACT
The present work was designed to investigate the presence of bioactive chemicals in the reaction mixtures (RMs) of peels of Valencia, Mandarin, and African navel oranges, through GC-MS and FT-IR studies. Limonene, a unique compound, is present in the RMs of the three orange peels. Moreover, hexadecanoic acid 2-hydroxy-1-(hydroxymethyl) ethyl ester was identified in the RMs of all the three-orange peels. The RM of Mandarin orange exhibited potent cytotoxic effect against MCF-7 ATCC human breast cancer cells (HBC). All the three RMs exhibited moderate antibacterial activity against the human pathogenic bacteria Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Enterococcus faecalis (ATCC 29212), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 700603), Salmonella choleraesis (ATCC 10708), Pseudomonas aeruginosa (ATCC 27853), and Proteus mirabilis (ATCC 299).
RESUMO
O presente trabalho almejou investigar a presença de produtos químicos bioativos nas misturas de reação (MRs) de cascas de Valência, Tangerina e laranja umbigo africana, por meio de estudos de GC-MS e FT-IR. Assim, constatou-se que limoneno, um composto único, está presente nos RMs das três cascas de laranja. Além disso, o éster 2-hidroxi1-(hidroximetil) etílico do ácido hexadecanóico foi identificado nos RMs de todas as cascas de três laranjas. A RM da tangerina exibiu potente efeito citotóxico contra células de câncer de mama humano (HBC) MCF-7 ATCC. Todos os três RMs exibiram atividade antibacteriana moderada contra as bactérias patogênicas humanas dos seguintes tipos Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Enterococcus faecalis (ATCC 29212), Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 700603), Salmonella choleraesis (ATCC 10708), Pseudomonas aeruginosa (ATCC 27853) e Proteus mirabilis (ATCC 299).
Licença
CC BY - Atribuição

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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Epiderme Vegetal / Citotoxinas / Citrus sinensis / Limoneno / Frutas Idioma: En Revista: Braz. j. biol Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Base de dados: VETINDEX Assunto principal: Epiderme Vegetal / Citotoxinas / Citrus sinensis / Limoneno / Frutas Idioma: En Revista: Braz. j. biol Ano de publicação: 2022 Tipo de documento: Article