The association between vitamin D and BDNF on cognition in older adults in Southern Brazil
Rev. saúde pública (Online)
; 56: 109, 2022. tab, graf
Article
em En
| LILACS
| ID: biblio-1424427
Biblioteca responsável:
BR67.1
ABSTRACT
ABSTRACT OBJECTIVE To estimate the association between vitamin D and the cognitive decline of older adults and evaluate whether this association is mediated by brain-derived neurotrophic factor (BDNF) serum concentration. METHODS Cross-sectional study nested in a population-based cohort. Of the 604 participants in the complementary examination of the EpiFloripa Study, 576 older adults (60 years or older) were eligible for the study. The outcome is cognitive decline evaluated by the Mini-Mental State Examination, the exposure is vitamin D, and BDNF is the mediator. The control variables are age, sex, per capita family income, and educational level. The direct effect of vitamin D and BDNF on cognitive decline and the indirect effect mediated by BDNF was evaluated using path analysis, with the estimation of standardized coefficients. RESULTS Among the participants, we observed a direct and positive effect of vitamin D on cognitive function (Coef 0.06; 95%CI 0.02 to 0.11; p < 0.001) and serum BDNF concentration (Coef 21.55; 95%CI 9.92 to 33.17; p = 0.002), i.e., the higher the vitamin D, the higher the cognitive function and serum level of BDNF. CONCLUSION There was an association between vitamin D on serum BDNF and on cognitive decline in older adults. Moreover, BDNF did not have an effect on cognitive decline, so BDNF was not a mediator of the vitamin D effect on cognitive decline.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Vitamina D
/
Idoso
/
Estudos Transversais
/
Cognição
/
Fator Neurotrófico Derivado do Encéfalo
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. saúde pública (Online)
Assunto da revista:
Sa£de P£blica
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Brasil
/
Singapura
País de publicação:
Brasil