Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 45(3): 226-235, May-June 2023. tab, graf
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1447586
Biblioteca responsável:
BR1.1
ABSTRACT
Objectives:
Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, including single nucleotide variants (SNVs) of dopamine-2 receptor (D2R), N-methyl-d-aspartate receptor (NMDAR), and cannabinoid receptor type 1 (CB1R), lifetime cannabis use, and childhood trauma.Methods:
Twenty-three SNVs of genes encoding D2R (DRD2 rs1799978, rs7131056, rs6275), NMDAR (GRIN1 rs4880213, rs11146020; GRIN2A rs1420040, rs11866328; GRIN2B rs890, rs2098469, rs7298664), and CB1R (CNR1 rs806380, rs806379, rs1049353, rs6454674, rs1535255, rs2023239, rs12720071, rs6928499, rs806374, rs7766029, rs806378, rs10485170, rs9450898) were genotyped in 143 first-episode psychosis patients (FEPp) and 286 community-based controls by Illumina HumanCoreExome-24 BeadChip. Gene-gene and gene-environment associations were assessed using nonparametric Multifactor Dimensionality Reduction software.Results:
Single-locus analyses among the 23 SNVs for psychosis and gene-gene interactions were not significant (p > 0.05 for all comparisons); however, both environmental risk factors showed an association with psychosis (p < 0.001). Moreover, gene-environment interactions were significant for an SNV in CNR1 and cannabis use. The best-performing model was the combination of CNR1 rs12720071 and lifetime cannabis use (p < 0.001), suggesting an increased risk of psychosis.Conclusion:
Our study supports the hypothesis of gene-environment interactions for psychosis involving T-allele carriers of CNR1 SNVs, childhood trauma, and cannabis use.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2023
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil
/
Reino Unido
País de publicação:
Brasil