Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report

Oliveira, Fábio Morato de; Souza, Vinícius Gonçalves de; Carvalho, Aparecida de Lourdes; Lizarte Neto, Fermino Sanches; Miranda, Carla Silva Siqueira

Oliveira, Fábio Morato de; Souza, Vinícius Gonçalves de; Carvalho, Aparecida de Lourdes; Lizarte Neto, Fermino Sanches; Miranda, Carla Silva Siqueira.

Afiliação

Oliveira, Fábio Morato de; Universidade Federal de Jataí. Jataí. BR
Souza, Vinícius Gonçalves de; Universidade Federal de Jataí. Jataí. BR
Carvalho, Aparecida de Lourdes; Universidade Federal de Jataí. Jataí. BR
Lizarte Neto, Fermino Sanches; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto. BR
Miranda, Carla Silva Siqueira; Universidade Federal de Jataí. Jataí. BR

Einstein (Säo Paulo) ; 21: eRC0378, 2023. graf

Article em En | LILACS-Express | LILACS | ID: biblio-1448182

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

ABSTRACT In equatorial Brazil, the association of Burkitt lymphoma and Epstein-Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein-Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient's condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.

Palavras-chave

Aurora kinases; Burkitt lymphoma; Epstein-Barr virus infections; HIV; Interfases; Pathology

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Risk_factors_studies Idioma: En Revista: Einstein (Säo Paulo) Assunto da revista: MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

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